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The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Additionally we are shipping CysLTR1 Antibodies (69) and CysLTR1 Kits (18) and many more products for this protein.
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SE sensitization may be a risk factor for TH2 inflammation in nonatopic asthma and late-onset asthma and for pulmonary function decline in nonatopic asthma. In women with asthma, a CysLTR1 promoter polymorphism may be associated with SEB sensitization.
In addition, TGF-beta1-induced expression of MMP-1 and MMP-3, generation of fibronectin and type I collagen production, focal adhesion kinase (FAK) and paxillin phosphorylation in HTFs were also ameliorated by montelukast in a dose dependent manner. These results suggested that montelukast might provide therapeutic possibilities for inhibition of scar formation after such surgery.
in allergen-sensitized individuals, exposure to allergen can enhance T cell expression of CysLT1. This, in turn, would induce enhanced CD4 (show CD4 Proteins)+ T cell responsiveness to cysLTs, T cell activation, and Th2 polarization.
CysLTR-1 and CysLTR-2 (show CYSLTR2 Proteins) are highly expressed in the adenoid tissues from children with AH, suggesting that leukotrienes are involved in the pathogenesis of AH.
The 5-LOX (show ALOX5 Proteins)/LTC4 /CysLT1 signaling pathway regulates EGF (show EGF Proteins)-induced cell migration by increasing Tiam1 (show TIAM1 Proteins) expression.
Cysteinyl leukotrienes signaling downstream of CysLT1R in mast cells is differentially regulated by two distinct PKCalpha (show PKCa Proteins) and PKC epsilon (show PRKCE Proteins).
CysLT(1) receptors in endothelial cells translocate to the nucleus in a ligand-independent manner after ischemic insult in vitro, and it is involved in the ischemic injury.
A significant relationship was found between the expression of CysLT1 receptor and GR-beta in nasal polyps (R = .525, P = .04), whereas there was no significant relationship between the expression of CysLT1 receptor and GR-alpha in nasal polyps.
A role of nuclear CysLT(1) receptor signaling in vascular smooth muscle cells inducing gene expression patterns associated with atherosclerosis.
Bronchial mucosal CysLT1 receptor-positive inflammatory cells are present in the bronchial mucosa in COPD (show ARCN1 Proteins) in greatest number in those experiencing a severe exacerbation.
this study shows that CysLT1R-deficient mice that were exposed to chlorine demonstrated airway hyperresponsiveness to inhaled methacholine significantly greater than in wild-type BALB/c mice
The important role that CysLTR1 plays in colorectal cancer and intestinal polyps development.
Leukotriene D4 and prostaglandin E2 signals synergize and potentiate vascular inflammation in a mast cell-dependent manner through cysteinyl leukotriene receptor 1 and E-prostanoid receptor 3
Involvement of CysLT1R in a model of asthma.
Suggest that myogenic tone is determined by AT1 (show SLC33A1 Proteins) and CysLT1 receptors acting together as mechanosensors via Gq/11-protein activation.
The CysLT(1) and CysLT(2 (show CYSLTR2 Proteins)) receptors were primarily localized in neurons, microglia and neutrophils
CysLT1R mediates LTD4-induced activation of microglial cells.
In an animal model of cognition impairment, CysLT1 receptor signaling is identified as proinflammatory and proamyloidogenic.
present novel data that CysLT1R is expressed on ILC2s and LTD potently induces CysLT1R-dependent ILC2 production of IL-4 (show IL4 Proteins), IL-5 (show IL5 Proteins), and IL-13 (show IL13 Proteins)
CysLT1R, CysLT2R (show CYSLTR2 Proteins) and GPR17 (show GPR17 Proteins) might be involved in the MPTP (show PTPN2 Proteins)-induced Parkinson disease damage in mice.
The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR2. This encoded receptor is a member of the superfamily of G protein-coupled receptors. Activation of this receptor by LTD4 results in contraction and proliferation of smooth muscle, oedema, eosinophil migration and damage to the mucus layer in the lung.
cysteinyl leukotriene receptor 1
, G-protein coupled receptor HG55
, LTD4 receptor
, cysteinyl leukotriene D4 receptor