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Cytochrome B-245, beta Polypeptide Proteins (CYBB)

Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. Additionally we are shipping CYBB Antibodies (115) and CYBB Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CYBB 1536 P04839
CYBB 13058 Q61093
Rat CYBB CYBB 66021  
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Top CYBB Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

CYBB Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,

More Proteins for Cytochrome B-245, beta Polypeptide (CYBB) Interaction Partners

Rabbit Cytochrome B-245, beta Polypeptide (CYBB) interaction partners

  1. Data indicate that NADPH oxidase (show NOX1 Proteins) NOx2 inhibition attenuates endoplasmic reticulum (ER) stress and apoptosis.

Human Cytochrome B-245, beta Polypeptide (CYBB) interaction partners

  1. Critical role of the Mac1 (show ITGAM Proteins)/NOX2 pathway in mediating reactive microgliosis-generated chronic neuroinflammation and progressive neurodegeneration

  2. Female patients with severe inflammatory bowel disease should be checked for X-CGD genes.

  3. Blunting of NOX2-dependent IKKepsilon (show IKBKE Proteins) oncogenic kinase expression reduces proliferation and viability of human breast cancer cells.

  4. Furthermore, a direct interaction between AnkA and HDAC1 (show HDAC1 Proteins) was detected at the CYBB promoter, and was critical for AnkA-mediated CYBB repression.

  5. There is a mutual enhancement between HMGB1 (show HMGB1 Proteins) and Nox2-derived reactive oxygen species in the diabetic retina.

  6. Study reports a putative NF-kB binding site within the distant 5' fl anking region of the CYBB gene, 15 kb upstream from the transcription start site, and provide evidence for its involvement in the regulation of CYBB gene expression in human phagocytes.

  7. increased levels of gp91phox, p47phox and p22phox (show CYBA Proteins) likely account for the interferon-gamma (show IFNG Proteins) mediated enhancement of dimethyl sulfoxide-induced Nox2 activity.

  8. NOX2 siRNA suppresses collagen production in primary keloid dermal fibroblasts.

  9. three cofactor independent human monoclonal aPL (show FASL Proteins) can induce transcription of NLRP3 (show NLRP3 Proteins) and caspase-1 (show CASP1 Proteins) resulting in inflammasome activation specific for NLRP3 (show NLRP3 Proteins), which depends fully on activation of endosomal NADPH-oxidase-2 (NOX2) by aPL (show FASL Proteins)

  10. Molecular switch from NOX1 (show NOX1 Proteins) to NOX2 in colon cancer cells induces ROS (show ROS1 Proteins) production and subsequently enhances MMP-7 (show MMP7 Proteins) expression by deactivating AMPK (show PRKAA1 Proteins).

Cow (Bovine) Cytochrome B-245, beta Polypeptide (CYBB) interaction partners

  1. Data indicate that the efficiency of NADPH oxidase (show NOX1 Proteins) enzymatic activity is higher at endoplasmic reticulum (ER).

  2. A p47(phox) and Src kinase activation of peroxide production by Nox2 appears to be an important contributor to vascular contractile mechanisms mediated through activation of protein kinase C

Mouse (Murine) Cytochrome B-245, beta Polypeptide (CYBB) interaction partners

  1. NADPH oxidase 2 inactivation causes regression of vascularization and the size and stability of atherosclerotic plaques

  2. Nox2 is implicated in the inflammatory and neovascular response to corneal chemical injury in mice

  3. NOX2 has a role in oxidative stress and mitochondrial abnormalities caused by saturated fat in cardiomyocytes

  4. Rnf145 implicated in proteostasis of the Nox2 complex

  5. Aging decreases prostanoid-mediated contractility in the carotid artery involving a loss of Nox2 activity and is associated with impaired endothelium-dependent, NO-mediated relaxation.

  6. eNOS (show NOS3 Proteins) plays a key role in the regulation of expression of NOX2 and NOX4 (show NOX4 Proteins) in the lungs exposed to hypoxia.

  7. Reactive oxygen species act as a negative feedback to constrain IL-1beta (show IL1B Proteins)-mediated inflammation, accounting for the more severe arthritis in the absence of NOX2.

  8. This study showed the contribution of NOD2 to inflammatory response and provided direct evidence that NOX2-mediated oxidative stress as an important target molecule linked NOD2 to inflammatory damage in ischemic stroke.

  9. results indicate that platelet and neutrophil NOX2-produced ROS (show ROS1 Proteins) are critical for the function of surface receptors essential for neutrophil-platelet interactions during vascular inflammation.

  10. Nox2 mRNA expression was increased in diet-induced obese (DIO) mice. Nox2 suppresses collateral vessel growth after femoral artery ligation in DIO mice.

Pig (Porcine) Cytochrome B-245, beta Polypeptide (CYBB) interaction partners

  1. sub-vasomotor concentration of ET-1 (show EDN1 Proteins) leads to vascular dysfunction by impairing endothelium-dependent NO-mediated dilation via p38 (show MAPK14 Proteins) kinase-mediated production of superoxide from NADPH oxidase (show NOX1 Proteins) following ETA receptor activation

  2. Reactive oxygen species generated by NADPH oxidase (show NOX1 Proteins) contribute to the aberrant pulmonary arterial responses in piglets exposed to 3 days of hypoxia.

  3. Upregulation of PPAR-gamma (show PPARG Proteins) and NADPH (show NQO1 Proteins) oxidases are involved in restenosis.

CYBB Protein Profile

Protein Summary

Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase\; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole.

Gene names and symbols associated with CYBB

  • cytochrome b-245, beta polypeptide (chronic granulomatous disease) (cybb)
  • cytochrome b-245, beta polypeptide (cybb)
  • cytochrome b-245, beta polypeptide (chronic granulomatous disease) (CYBB)
  • cytochrome b-245, beta polypeptide (CYBB)
  • cytochrome b-245 beta polypeptide (CYBB)
  • cytochrome b-245, beta polypeptide (Cybb)
  • NADPH oxidase heavy chain subunit (GP91-PHOX)
  • AMCBX2 protein
  • C88302 protein
  • Cgd protein
  • CGD91-phox protein
  • CYBB protein
  • Cyd protein
  • GP91-1 protein
  • Gp91-phox protein
  • GP91PHOX protein
  • NOX1 protein
  • Nox2 protein
  • p91-PHOX protein
  • zgc:64144 protein

Protein level used designations for CYBB

cytochrome b-245, beta polypeptide , gp91 , NADPH oxidase 2 , cytochrome b-245, beta polypeptide (chronic granulomatous disease) , Cytochrome b-245 heavy chain , NADPH oxidase heavy chain subunit , NADPH oxidase 1 , NADPH oxidase flavocytochrome b subunit , cytochrome b-245 heavy chain , gp91-phox , CGD91-phox , cytochrome b(558) subunit beta , cytochrome b558 subunit beta , heme-binding membrane glycoprotein gp91phox , neutrophil cytochrome b 91 kDa polypeptide , p22 phagocyte B-cytochrome , superoxide-generating NADPH oxidase heavy chain subunit , gp91-1 , endothelial type gp91-phox , predicted NADPH oxidase-2

GENE ID SPECIES
393386 Danio rerio
595081 Xenopus (Silurana) tropicalis
696542 Macaca mulatta
444353 Xenopus laevis
100036757 Ovis aries
100270807 Salmo salar
100008801 Oryctolagus cuniculus
1536 Homo sapiens
418581 Gallus gallus
281112 Bos taurus
13058 Mus musculus
66021 Rattus norvegicus
491825 Canis lupus familiaris
397108 Sus scrofa
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