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Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases (By similarity)..
Four crystal structures of the solubilized haem-binding domain of cytochrome b5 (show CYB5A Antibodies) from porcine liver were determined at sub-angstrom resolution (0.76-0.95 A) in two crystal forms for both the oxidized and reduced states.
These results demonstrate the differential effects of two forms of CYB5 (show CYB5A Antibodies) on the three activities of porcine CYP17A1 (show CYP17A1 Antibodies) and show that CYB5B does not stimulate the andien-beta synthase activity of CYP17A1 (show CYP17A1 Antibodies).
The presence of a novel reductive enzyme system of importance for lipid synthesis that is exclusively localized to the outer mitochondrial membrane and is composed of CYB5B, MOSC2 (show MARC2 Antibodies), and a third unknown component (a CYB5B reductase).
microsomal cytochrome b5 (show CYB5A Antibodies) interacts with neuronal calcium sensor protein visinin-like protein-3 (show HPCAL1 Antibodies) in a Ca2 (show CA2 Antibodies)+-dependent manner
the hydroxylation of dihydroceramide: sphinganine C-4 requires complex formation between Des2 (show DEGS2 Antibodies) and mb5 via their membrane-spanning domains and electron transfer from NADH to the substrate via the reduction of mb5 by b5R (show CYB5R3 Antibodies)
microsomal cytochrome b5 (show CYB5A Antibodies) can play a major role in the in vivo metabolism of certain drugs and chemicals but in a P450 (show POR Antibodies)- and substrate-dependent manner
Data indicate that mitochondrial amidoxime reducing components 1 and 2 together with the electron transport proteins NADH-cytochrome b5 reductase (CYB5R) and cytochrome b5 (CYB5 (show CYB5A Antibodies)) catalyze the reduction of N-hydroxylated compounds such as amidoximes.
comparison of X-ray crystal structures of human and rat CYB5B reveals a striking difference in packing involving the five-strand beta-sheet, which can be attributed to fully buried residue 21 in strand beta4
The 21 kDa protein overexpressed in Hodgkin Lymphoma and aggressive non-Hodgkin Lymphomas is identical to CYB5B.
could be involved in the differential modulation of 17 alpha-hydroxylase and 17,20-lyase activities of P450c17 [type2 cyt-b5]
Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases (By similarity).
cytochrome b5 type B (outer mitochondrial membrane)
, cytochrome b5 type B
, cytochrome b5 outer mitochondrial membrane isoform
, outer mitochondrial membrane cytochrome b5
, type 2 cyt-b5
, cytochrome b5, outer mitochondrial membrane isoform