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Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. Additionally we are shipping Cytochrome C Oxidase Subunit IV Isoform 2 (Lung) Proteins (3) and many more products for this protein.
Showing 10 out of 44 products:
Human Monoclonal COX4I2 Primary Antibody for IHC (p), IP - ABIN566588
Singh, Misiak, Beyer, Arnold: Brain region specificity of 3-nitropropionic acid-induced vulnerability of neurons involves cytochrome c oxidase. in Neurochemistry international 2010
Show all 5 references for ABIN566588
Human Polyclonal COX4I2 Primary Antibody for IF, ELISA - ABIN1534368
Hüttemann, Kadenbach, Grossman: Mammalian subunit IV isoforms of cytochrome c oxidase. in Gene 2001
Show all 2 references for ABIN1534368
Data (including data from cells of transgenic mouse embryos) suggest Hif1a (hypoxia inducible factor 1 alpha subunit) up-regulates transcription of heart/muscle isoform Cox7a1 (show COX7A1 Antibodies) under hypoxia; hypoxic induction of isoform Cox4i2 is HIF1a (show HIF1A Antibodies)-independent.
propose a model in which reduced tissue ATP levels explain protection from airway hyperresponsiveness, i.e., absence of COX4i2 leads to reduced lung COX (show CPOX Antibodies) activity and ATP levels, which results in impaired airway constriction
the presence of the COX (show CPOX Antibodies) isoform IV-2 suppresses the sensitivity of COX (show CPOX Antibodies) to its allosteric regulator ATP and overrules the regulation of COX (show CPOX Antibodies) by the cellular energy level
Cytochrome c oxidase subunit IV (show COX4I1 Antibodies) is essential for assembly and respiratory function of the enzyme complex.
Under conditions of reduced oxygen availability, hypoxia-inducible factor 1 (show HIF1A Antibodies) reciprocally regulates COX4 (show COX4I1 Antibodies) subunit expression by activating transcription of the genes encoding COX4-2 and LON (show LONP1 Antibodies), a mitochondrial protease that is required for COX4-1 (show COX4I1 Antibodies) degradation.
Identification of three transcription factors that bind a conserved responsive element of the COX4I2 gene, namely recombination signal sequence-binding protein Jkappa (RBPJ (show RBPJ Antibodies)), coiled-coil-helix-coiled-coil-helix domain 2 (CHCHD2) and CXXC finger protein 5 (CXXC5 (show CXXC5 Antibodies)).
Mutation analysis of COX4I2 is warranted in patients with malabsorption due to exocrine pancreatic insufficiency and in patients with dyserythropoeitic anemia.
COX4I2 is regulated by a novel oxygen sensitive promoter element (5'-GGACGTTCCCACG-3') conserved in mammals. Gene activity is maximal at 4% oxygen. Lung cytochrome c oxidase (COX) is 2.5 fold more active compared to liver COX, which lacks COX4I2.
COX4I2 is expressed in the highly oxygenated lung tissue. It is found in all cell types of the lung.
Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes isoform 2 of subunit IV. Isoform 1 of subunit IV is encoded by a different gene, however, the two genes show a similar structural organization. Subunit IV is the largest nuclear encoded subunit which plays a pivotal role in COX regulation.
, cytochrome c oxidase subunit 4 isoform 2, mitochondrial
, cytochrome c oxidase, subunit IVb
, COX IV-2
, cytochrome c oxidase subunit IV-like 2
, cytochrome c oxidase, subunit 4b