Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 Proteins (CYP2D6)

CYP2D6 encodes a member of the cytochrome P450 superfamily of enzymes. Additionally we are shipping Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 Antibodies (132) and Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 Kits (11) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat CYP2D6 CYP2D6 171522 Q64680
CYP2D6 1565 P10635
CYP2D6    
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Top Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 Proteins at antibodies-online.com

Showing 10 out of 16 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
HOST_Yeast (Pichia pastoris) Human Un-conjugated   10 mg Log in to see 2 to 3 Days
$125.00
Details
Yeast Pan paniscus His tag   1 mg Log in to see 60 to 71 Days
$3,408.17
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
HOST_Insect cells (Sf9) Human Un-conjugated   5 μg Log in to see 2 to 3 Days
$155.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 18 Days
$688.00
Details
Yeast Pan troglodytes His tag   1 mg Log in to see 60 to 71 Days
$3,408.17
Details
HOST_Insect cells (Sf9) Human Un-conjugated   1 mg Log in to see 2 to 3 Days
$3,978.07
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days
$893.75
Details

CYP2D6 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, , ,
Pan paniscus

More Proteins for Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 (CYP2D6) Interaction Partners

Human Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 (CYP2D6) interaction partners

  1. A total of 72 single nucleotide polymorphisms were identified. CYP2D6*1, *2, *4, *5, *10,*41, and duplication of the gene were found in the Orang Asli, whereby CYP2D6*2 and *41 alleles are reported for the first time in the Malaysian population

  2. Data suggest that expression of CYP2D6 in hepatocytes is repressed by MIRN370 (hsa-miR-370-3p); MIRN370 represses expression of CYP2D6 even under the influence of CYP2D6 inducer (the glucocorticoid dexamethasone); the mechanism appears to involve the facilitation of CYP2D6 mRNA degradation. (CYP2D6 = cytochrome P450 family 2 subfamily D member 6; MIRN370 = microRNA 370)

  3. Report predicted and measured CYP2D6 phenotype in a diverse South African population.

  4. No association between cytochrome P450 CYP2D6 ultra-rapid metabolizer status and attempted suicide was observed in bivariate

  5. Studied frequency of ADRB1 (show ADRB1 Proteins) Arginine389Glycine (Arg389Gly) and Cytochrome p450 2D6*10 (Cyp2D6*10) polymorphism in cases of heart failure-reduced ejection fraction (HFREF), and to evaluate the influence of the polymorphisms in response to beta-blocker (BB) therapy; found a statistically significant association was observed with CC genotype and Glisin-Glisin (GG) genotype.

  6. Variant genotypes of CYP2D6 are associated with an increased risk of esophageal squamous cell carcinoma in Kashmir, India.

  7. genetic variation in CYP2D6 is a key predictor for the response to tamoxifen in patients with breast cancer

  8. These results indicated that most of the allelic variants of CYP2D6 studied here, exhibited significantly decreased enzymatic activities towards methadone N-demethylation.

  9. Evaluation of CYP2D6 ultrarapid metabolism should take into account activity of the multiplied alleles to avoid potential misclassification.

  10. Of 830 patients with sickle cell disease, 621 (75%) had a CYP2D6 genotype result; 7.1% were ultra-rapid or possible ultra-rapid metabolizers, and 1.4% were poor metabolizers.

Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 (CYP2D6) Protein Profile

Protein Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug\; sparteine and propafenone, both anti-arrythmic drugs\; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population\; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with CYP2D6

  • cytochrome 2D6 (CYP2D6)
  • cytochrome P450 2D6 (CYP2D6)
  • cytochrome P450, family 2, subfamily D, polypeptide 6 (CYP2D6)
  • cytochrome P450, family 2, subfamily D, polypeptide 6 (cyp2d6-b)
  • cytochrome P450, family 2, subfamily D, polypeptide 6 (cyp2d6)
  • cytochrome P450, family 2, subfamily d, polypeptide 4 (Cyp2d4)
  • cytochrome P450, family 2, subfamily D, polypeptide 6 (CYP2D14)
  • CPD6 protein
  • CYP2D protein
  • cyp2d2 protein
  • Cyp2d4v1 protein
  • Cyp2d4v2 protein
  • CYP2D6 protein
  • cyp2d6-a protein
  • CYP2D7AP protein
  • CYP2D7BP protein
  • CYP2D7P2 protein
  • CYP2D8P2 protein
  • Cyp2d18 protein
  • Cyp2d22 protein
  • CYP2D42 protein
  • CYP2DL1 protein
  • CYPIID6 protein
  • MGC64445 protein
  • P450-DB1 protein
  • P450C2D protein
  • P450DB1 protein

Protein level used designations for CYP2D6

cytochrome P450 2D6 , cytochrome P450 CYP2D42 , cytochrome P450, family 2, subfamily D, polypeptide 6 , CYPIID18 , CYPIID4 , Cytochrome P450, subfamily IID4 , P450 2D-29/2D-35 , P450-CMF3 , P450-DB4 , cytochrome P450 2D-29 , cytochrome P450 2D-35 , cytochrome P450 2D4 , cytochrome P450 2d18 , cytochrome P450, family 2, subfamily d, polypeptide 22 , cytochrome P450, subfamily 2D, polypeptide 6 , cytochrome P450, subfamily IID, polypeptide 6 , cytochrome P450-CMF3 , cytochrome P450-DB4 , debrisoquine 4-hydroxylase , cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 2 , cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2 , cytochrome P450, subfamily II (debrisoquine, sparteine, etc., -metabolising), polypeptide 7 pseudogene 2 , cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolising), polypeptide 8 pseudogene 2 , cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), polypeptide 6 , cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing)-like 1 , cytochrome P450-DB1 , flavoprotein-linked monooxygenase , microsomal monooxygenase , xenobiotic monooxygenase , CYPIID14 , cytochrome P450 2D14 , CYPIID6

GENE ID SPECIES
100500743 Felis catus
100568286 Ovis aries
678691 Macaca mulatta
379479 Xenopus laevis
446878 Xenopus laevis
548436 Xenopus (Silurana) tropicalis
171522 Rattus norvegicus
1565 Homo sapiens
282211 Bos taurus
470228 Pan troglodytes
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