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CYP3A4 encodes a member of the cytochrome P450 superfamily of enzymes. Additionally we are shipping CYP3A4 Kits (27) and CYP3A4 Proteins (6) and many more products for this protein.
Showing 10 out of 118 products:
Human Polyclonal CYP3A4 Primary Antibody for EIA, WB - ABIN360097
Nelson, Zeldin, Hoffman, Maltais, Wain, Nebert: Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. in Pharmacogenetics 2004
Show all 3 references for ABIN360097
Human Monoclonal CYP3A4 Primary Antibody for ICC, FACS - ABIN969512
van Waterschoot, Rooswinkel, Sparidans, van Herwaarden, Beijnen, Schinkel: Inhibition and stimulation of intestinal and hepatic CYP3A activity: studies in humanized CYP3A4 transgenic mice using triazolam. in Drug metabolism and disposition: the biological fate of chemicals 2009
Show all 2 references for ABIN969512
Human Polyclonal CYP3A4 Primary Antibody for IHC, ELISA - ABIN1450923
Mungall, Palmer, Sims, Edwards, Ashurst, Wilming, Jones, Horton, Hunt, Scott, Gilbert, Clamp, Bethel, Milne, Ainscough, Almeida, Ambrose, Andrews, Ashwell, Babbage, Bagguley, Bailey, Banerjee, Barker et al.: The DNA sequence and analysis of human chromosome 6. ... in Nature 2003
Show all 2 references for ABIN1450923
Human Polyclonal CYP3A4 Primary Antibody for IP, WB - ABIN947776
Fujiwara, Itoh: Extensive protein interactions involving cytochrome P450 3A4: a possible contributor to the formation of a metabolosome. in Pharmacology research & perspectives 2014
Human Polyclonal CYP3A4 Primary Antibody for WB - ABIN2784528
Werk, Lefeldt, Bruckmueller, Hemmrich-Stanisak, Franke, Roos, Küchle, Steubl, Schmaderer, Bräsen, Heemann, Cascorbi, Renders: Identification and characterization of a defective CYP3A4 genotype in a kidney transplant patient with severely diminished tacrolimus clearance. in Clinical pharmacology and therapeutics 2014
It was concluded that CYP3A related metabolism in horse is not solely dependent on the expression of the enzyme but also on adequate levels of NADPH P450 reductase (show POR Antibodies) and cytochrome b(5 (show CYB5A Antibodies)).
Metabolism of amiodarone to desethylamiodarone by CYP1A1 (show CYP1A1 Antibodies) or CYP3A4 plays an important role in the hepatocellular toxicity of amiodarone.
Report roles for CYP3A4 and CYP2C9 (show CYP2C9 Antibodies) in sequential two-step bioactivation of diclofenac to reactive p-benzoquinone imines.
SLCO1B1 (show SLCO1B1 Antibodies) rs113681054, SLCO1B1 (show SLCO1B1 Antibodies)*5 (rs4149056), CYP3A4*1G (rs2242480), and CYP3A4*5 (rs776746) polymorphisms had no effect on the PK/PD of ticagrelor in healthy Chinese volunteers
Data suggest that CYP3A4 (cytochrome P-450 (show CYP Antibodies) 3A4) is involved in proliferation, migration, invasion, and colony formation abilities of hepatocellular carcinoma cells; in HEPG2 cells, the naturally occurring flavonoid rutin (an antioxidant anticarcinogen) inhibits progression (inhibits proliferation, migration, etc.), promotes apoptosis, and down-regulates expression of CYP3A4.
effector-dependent conformational equilibrium between open and closed states of CYP3A4
The combination of an in vivo drug-drug interaction (DDI) study with NVS123 and the potent CYP3A4 inhibitor ritonavir in hCYP3A4 mice along with physiologically based pharmacokinetic modeling modeling allowed for a prospective prediction of the extent of DDI and boost effect in humans, which was subsequently confirmed in a clinical study.
Suggest that benzbromarone is a mechanism-based CYP3A4 inhibitor.
This study found significant changes in the disposition of lidocaine hydrochloride in native healthy Tibetan and Han Chinese subjects living at a high altitude in comparison to healthy Han Chinese subjects living at low altitude, which might be due to significant decreases in the activity and protein and mRNA expression of CYP3A4 under chronic high altitude hypoxia condition.
CYP2D6 and CYP3A activities were shown to have moderate contribution on clearance of tramadol enantiomers.
decreases of CES and CYP3A4 expression and enzymatic activities induced by Fluoxetine are through decreasing PXR (show NR1I2 Antibodies) and increasing DEC1 (show BHLHE40 Antibodies) in HepG2 cells
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist\; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.
cytochrome P450 3A4
, cytochrome P450, family 3, subfamily A, polypeptide 4
, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4
, Cytochrome P450 CM3A-10
, cytochrome P450 3A21
, 1,8-cineole 2-exo-monooxygenase
, P450-III, steroid inducible
, albendazole monooxygenase
, albendazole sulfoxidase
, cytochrome P450 3A3
, cytochrome P450 HLp
, cytochrome P450 NF-25
, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3
, cytochrome P450-PCN1
, glucocorticoid-inducible P450
, nifedipine oxidase
, quinine 3-monooxygenase
, taurochenodeoxycholate 6-alpha-hydroxylase
, cytochrome P450 CYP3A12
, cytochrome P450 3A80