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anti-Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 (CYP3A4) Antibodies

CYP3A4 encodes a member of the cytochrome P450 superfamily of enzymes. Additionally we are shipping CYP3A4 Kits (27) and CYP3A4 Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CYP3A4 1576 P08684
CYP3A4    
CYP3A4    
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Top anti-CYP3A4 Antibodies at antibodies-online.com

Showing 10 out of 118 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-CYP3A4 Antibody Titration: 0.2-1 ug/mlPositive Control: THP-1 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated EIA, FACS, IF, IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
$423.50
Details
Human Mouse Un-conjugated ICC, FACS, IHC, ELISA, WB Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 ng), Blue: Antigen (100 ng) Figure 2: Flow cytometric analysis of HepG2 cells using CYP3A4 mouse mAb (green) and negative control (red) . 0.1 mg Log in to see 3 to 4 Days
$430.10
Details
Human Rabbit Un-conjugated IHC, ELISA, WB   100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IF, IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of CYP3A4 Antibody (Center) (ABIN392216) in NCI-H460 cell line lysates (35 µg/lane). CYP3A4 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IP, WB CYP3A4 MaxPab rabbit polyclonal antibody. Western Blot analysis of CYP3A4 expression in HepG2. Immunoprecipitation of CYP3A4 transfected lysate using anti-CYP3A4 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead , and immunoblotted with CYP3A4 purified MaxPab mouse polyclonal antibody (B01P) . 100 μL Log in to see 9 Days
$418.57
Details
Human Rabbit Un-conjugated WB Western blot analysis of Cytochrome P450 3A4 expression in NCIH460 (A), human liver (B) whole cell lysates. 200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Un-conjugated IHC (p), WB   100 μg Log in to see 4 to 6 Days
$240.00
Details

CYP3A4 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-CYP3A4 Antibodies

  1. Human Polyclonal CYP3A4 Primary Antibody for EIA, WB - ABIN360097 : Nelson, Zeldin, Hoffman, Maltais, Wain, Nebert: Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. in Pharmacogenetics 2004 (PubMed)
    Show all 3 references for ABIN360097

  2. Human Monoclonal CYP3A4 Primary Antibody for ICC, FACS - ABIN969512 : van Waterschoot, Rooswinkel, Sparidans, van Herwaarden, Beijnen, Schinkel: Inhibition and stimulation of intestinal and hepatic CYP3A activity: studies in humanized CYP3A4 transgenic mice using triazolam. in Drug metabolism and disposition: the biological fate of chemicals 2009 (PubMed)
    Show all 2 references for ABIN969512

  3. Human Polyclonal CYP3A4 Primary Antibody for IHC, ELISA - ABIN1450923 : Mungall, Palmer, Sims, Edwards, Ashurst, Wilming, Jones, Horton, Hunt, Scott, Gilbert, Clamp, Bethel, Milne, Ainscough, Almeida, Ambrose, Andrews, Ashwell, Babbage, Bagguley, Bailey, Banerjee, Barker et al.: The DNA sequence and analysis of human chromosome 6. ... in Nature 2003 (PubMed)
    Show all 2 references for ABIN1450923

  4. Human Polyclonal CYP3A4 Primary Antibody for IP, WB - ABIN947776 : Fujiwara, Itoh: Extensive protein interactions involving cytochrome P450 3A4: a possible contributor to the formation of a metabolosome. in Pharmacology research & perspectives 2014 (PubMed)

  5. Human Polyclonal CYP3A4 Primary Antibody for WB - ABIN2784528 : Werk, Lefeldt, Bruckmueller, Hemmrich-Stanisak, Franke, Roos, Küchle, Steubl, Schmaderer, Bräsen, Heemann, Cascorbi, Renders: Identification and characterization of a defective CYP3A4 genotype in a kidney transplant patient with severely diminished tacrolimus clearance. in Clinical pharmacology and therapeutics 2014 (PubMed)

More Antibodies against CYP3A4 Interaction Partners

Horse (Equine) Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 (CYP3A4) interaction partners

  1. It was concluded that CYP3A related metabolism in horse is not solely dependent on the expression of the enzyme but also on adequate levels of NADPH P450 reductase (show POR Antibodies) and cytochrome b(5 (show CYB5A Antibodies)).

Human Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 (CYP3A4) interaction partners

  1. Metabolism of amiodarone to desethylamiodarone by CYP1A1 (show CYP1A1 Antibodies) or CYP3A4 plays an important role in the hepatocellular toxicity of amiodarone.

  2. Report roles for CYP3A4 and CYP2C9 (show CYP2C9 Antibodies) in sequential two-step bioactivation of diclofenac to reactive p-benzoquinone imines.

  3. SLCO1B1 (show SLCO1B1 Antibodies) rs113681054, SLCO1B1 (show SLCO1B1 Antibodies)*5 (rs4149056), CYP3A4*1G (rs2242480), and CYP3A4*5 (rs776746) polymorphisms had no effect on the PK/PD of ticagrelor in healthy Chinese volunteers

  4. Data suggest that CYP3A4 (cytochrome P-450 (show CYP Antibodies) 3A4) is involved in proliferation, migration, invasion, and colony formation abilities of hepatocellular carcinoma cells; in HEPG2 cells, the naturally occurring flavonoid rutin (an antioxidant anticarcinogen) inhibits progression (inhibits proliferation, migration, etc.), promotes apoptosis, and down-regulates expression of CYP3A4.

  5. effector-dependent conformational equilibrium between open and closed states of CYP3A4

  6. The combination of an in vivo drug-drug interaction (DDI) study with NVS123 and the potent CYP3A4 inhibitor ritonavir in hCYP3A4 mice along with physiologically based pharmacokinetic modeling modeling allowed for a prospective prediction of the extent of DDI and boost effect in humans, which was subsequently confirmed in a clinical study.

  7. Suggest that benzbromarone is a mechanism-based CYP3A4 inhibitor.

  8. This study found significant changes in the disposition of lidocaine hydrochloride in native healthy Tibetan and Han Chinese subjects living at a high altitude in comparison to healthy Han Chinese subjects living at low altitude, which might be due to significant decreases in the activity and protein and mRNA expression of CYP3A4 under chronic high altitude hypoxia condition.

  9. CYP2D6 and CYP3A activities were shown to have moderate contribution on clearance of tramadol enantiomers.

  10. decreases of CES and CYP3A4 expression and enzymatic activities induced by Fluoxetine are through decreasing PXR (show NR1I2 Antibodies) and increasing DEC1 (show BHLHE40 Antibodies) in HepG2 cells

CYP3A4 Antigen Profile

Protein Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist\; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with CYP3A4

  • cytochrome P450 3A4 (PTRG_01782) antibody
  • cytochrome P450 3A4 (PTRG_06060) antibody
  • cytochrome P450, family 3, subfamily A, polypeptide 4 (cyp3a4) antibody
  • cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4) antibody
  • cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4 (CYP3A4) antibody
  • cytochrome P450, subfamily IIIA, polypeptide 4 (CYP3A4) antibody
  • CP33 antibody
  • CP34 antibody
  • CYP3A antibody
  • CYP3A3 antibody
  • CYP3A4 antibody
  • CYP3A12 antibody
  • CYP3A21 antibody
  • CYP3A80 antibody
  • CYPIIIA3 antibody
  • CYPIIIA4 antibody
  • CYPIIIA21 antibody
  • HLP antibody
  • MGC108372 antibody
  • NF-25 antibody
  • P450C3 antibody
  • P450PCN1 antibody

Protein level used designations for CYP3A4

cytochrome P450 3A4 , cytochrome P450, family 3, subfamily A, polypeptide 4 , cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4 , Cytochrome P450 CM3A-10 , cytochrome P450 3A21 , 1,8-cineole 2-exo-monooxygenase , P450-III, steroid inducible , albendazole monooxygenase , albendazole sulfoxidase , cytochrome P450 3A3 , cytochrome P450 HLp , cytochrome P450 NF-25 , cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3 , cytochrome P450-PCN1 , glucocorticoid-inducible P450 , nifedipine oxidase , quinine 3-monooxygenase , taurochenodeoxycholate 6-alpha-hydroxylase , cytochrome P450 CYP3A12 , cytochrome P450 3A80

GENE ID SPECIES
6339762 Pyrenophora tritici-repentis Pt-1C-BFP
6344316 Pyrenophora tritici-repentis Pt-1C-BFP
548503 Xenopus (Silurana) tropicalis
463582 Pan troglodytes
100037189 Xenopus laevis
100294525 Equus caballus
100404344 Callithrix jacchus
100462903 Macaca mulatta
1576 Homo sapiens
479740 Canis lupus familiaris
416477 Gallus gallus
507988 Bos taurus
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