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CYP7B1 encodes a member of the cytochrome P450 superfamily of enzymes. Additionally we are shipping Cytochrome P450, Family 7, Subfamily B, Polypeptide 1 Proteins (6) and Cytochrome P450, Family 7, Subfamily B, Polypeptide 1 Kits (4) and many more products for this protein.
Showing 10 out of 73 products:
Human Polyclonal CYP7B1 Primary Antibody for IHC, ELISA - ABIN185122
Wu, Martin, Javitt, Chiang: Structure and functions of human oxysterol 7alpha-hydroxylase cDNAs and gene CYP7B1. in Journal of lipid research 2000
Human Polyclonal CYP7B1 Primary Antibody for FACS, IF - ABIN652732
Schwarz, Lund, Russell: Two 7 alpha-hydroxylase enzymes in bile acid biosynthesis. in Current opinion in lipidology 1998
tissue-specific steroid concentrations may have a strong impact on CYP7B1-dependent catalysis and thus on the levels of different CYP7B1-related steroids that can influence estrogen receptor beta (show ESR2 Antibodies) signaling
Data indicated that the two GWAS-defined variants in the CYP7B1 region do not strongly influence HIV-1 infection susceptibility.
Using an agnostic omics approach to focus on the association of CWP with body mass index, we have confirmed a steroid hormone association and identified a genetic variant upstream of the CYP (show PPIG Antibodies) genes, which likely controls this response.
Spastic paraplegia type 5 has a higher frequency in Taiwanese than in other ethnic groups, associated with a CYP7B1 founder mutation and its phenotype is characterized by pronounced dorsal column sensory loss, with cerebellar ataxia (show USP14 Antibodies) in some patients.
The patient was homozygous for a mutation (c.1249C>T) in CYP7B1 that alters a highly conserved residue in oxysterol 7 alpha-hydroxylase previously reported in a family with hereditary spastic paraplegia type 5
enduring sensory ataxia (show USP14 Antibodies) can be a pivotal sign in SPG5, and expands the phenotypic spectrum associated with mutations in CYP7B1
21-hydroxy-pregnenolone was identified as a new substrate, and overall low activity toward pregnanes could be related to the increased potency of 7-hydroxy derivatives produced by CYP7B1.
investigation of CYP7B1-substrate binding modes
Description of a homology model for human CYP7B1 that provides valuable information on the active site architecture, along with docking studies that analyzed ligand-binding interactions.
Five CYP7B1 mutations, three of which are novel, were identified in four patients with hereditary spastic paraplegia type 5.
analysis of the first Japanese patient with an oxysterol 7alpha-hydroxylase deficiency associated with compound heterozygous mutations of the CYP7B1 gene [case report]
Findings indicate that CYP7B1 and HSD3B7 (show HSD3B7 Antibodies), as well as CH25H (show CH25H Antibodies), have essential roles in controlling oxysterol production in lymphoid tissues.
Because CYP7B1 represents the major pathway for inactivating 3betaAdiol in the prostate, we suggest that ERbeta (show ESR2 Antibodies), 3betaAdiol, and CYP7B1 are the components of a pathway that regulates growth of the rodent ventral prostate.
Identification of Cyp7b1 as a novel RORalpha (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3).
Data show that ten genes (Fsp27 (show CIDEC Antibodies), Aqp4 (show AQP4 Antibodies), Cd36 (show CD36 Antibodies), Ly6d (show LY6D Antibodies), Scd1 (show SCD Antibodies), Hsd3b5, Syt1 (show SYT1 Antibodies), Cyp7b1, and Tff3 (show TFF3 Antibodies)) showed significant associations among their expressions and the degree of hepatic steatosis.
CYP7B1-mediated catalysis may play a role for control of the cellular levels of androgens, not only of estrogens.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway of extrahepatic tissues, which converts cholesterol to bile acids. This enzyme likely plays a minor role in total bile acid synthesis, but may also be involved in the development of atherosclerosis, neurosteroid metabolism and sex hormone synthesis.
, cytochrome P450, family 7, subfamily B, polypeptide 1
, 25-hydroxycholesterol 7-alpha-hydroxylase
, cytochrome P450 7B1
, cytochrome P450, subfamily VIIB (oxysterol 7 alpha-hydroxylase), polypeptide 1
, oxysterol 7-alpha-hydroxylase
, cytochrome P450, 7b1
, hippocampal transcript 1 protein
, cytochrome P450, subfamily 7B, polypeptide 1