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The protein encoded by CRLF2 is a receptor for thymic stromal lymphopoietin (TSLP). Additionally we are shipping CRLF2 Proteins (13) and CRLF2 Kits (6) and many more products for this protein.
Showing 10 out of 93 products:
Human Monoclonal CRLF2 Primary Antibody for IF, IHC - ABIN2663948
Wang, Ito, Wang, Homey, Watanabe, Martin, Barnes, McIntyre, Gilliet, Kumar, Yao, Liu: Maintenance and polarization of human TH2 central memory T cells by thymic stromal lymphopoietin-activated dendritic cells. in Immunity 2006
Show all 5 references for ABIN2663948
Human Monoclonal CRLF2 Primary Antibody for FACS, ICFC - ABIN2658841
Zhang, Wang, Wang, Chen, Zhang, Chen, Wan, Zhang, Cao: Identification of a novel type I cytokine receptor CRL2 preferentially expressed by human dendritic cells and activated monocytes. in Biochemical and biophysical research communications 2001
Show all 4 references for ABIN2658841
Human Monoclonal CRLF2 Primary Antibody for FACS, IF - ABIN2659406
Reche, Soumelis, Gorman, Clifford, Liu Mr, Travis, Zurawski, Johnston, Liu, Spits, de Waal Malefyt, Kastelein, Bazan: Human thymic stromal lymphopoietin preferentially stimulates myeloid cells. in Journal of immunology (Baltimore, Md. : 1950) 2001
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Human Monoclonal CRLF2 Primary Antibody for FACS, CyTOF - ABIN2660246
Tonozuka, Fujio, Sugiyama, Nosaka, Hirai, Kitamura: Molecular cloning of a human novel type I cytokine receptor related to delta1/TSLPR. in Cytogenetics and cell genetics 2001
Show all 4 references for ABIN2660246
Human Polyclonal CRLF2 Primary Antibody for EIA, IHC (p) - ABIN501083
Ziegler, Liu: Thymic stromal lymphopoietin in normal and pathogenic T cell development and function. in Nature immunology 2006
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Human Polyclonal CRLF2 Primary Antibody for IHC (p), WB - ABIN318884
Park, Martin, Garka, Gliniak, Di Santo, Muller, Largaespada, Copeland, Jenkins, Farr, Ziegler, Morrissey, Paxton, Sims: Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: Formation of a functional heteromeric complex requires interleukin 7 receptor. in The Journal of experimental medicine 2000
In adult B-cell acute lymphoblastic leukemia without recurrent fusion genes , high CRLF2 expression is associated with distinct clinico-biological features and an unfavourable prognosis
CD4 (show CD4 Antibodies)+ T cells from atopic dermatitis patients directly interacted with TSLP (show TSLP Antibodies) to produce a higher amount of IL-4 (show IL4 Antibodies) than those from normal subjects, and this action was attenuated with anti-TSLPR antibody
The levels of mRNA for TSLP (show TSLP Antibodies) and TSLPR were significantly elevated in parotid gland tissues from the KD group as compared to the control group.
Differences exist in the genetic profiles of Down syndrome-associated acute lymphoblastic leukemia patients in Japan and in Western countries, and that P2RY8 (show P2RY8 Antibodies)-CRLF2 and EBF1 (show EBF1 Antibodies) deletions may cooperate in leukemogenesis in a subset of Japanese DS-ALL patients.
CRLF2 overexpression (OE) was detected in 30 (18%) of 167 patients, the P2RY8-CRLF2 fusion was identified in only 3 (1.8%) of 167 patients, all of which demonstrated CRLF2 OE.
we report noncysteine in-frame mutations in IL7R (show IL7R Antibodies) and CRLF2 located in a region of the transmembrane domain closer to the cytosolic domain in acute lymphoblastic leukemias
The TSLPR in blood plateltes promotes platelet activation via activating the PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) pathway.
both IKZF1 (show IKZF1 Antibodies) deletions and IGH@-CRLF2 are associated with an increased risk of treatment failure in adult acute lymphoblastic leukemia
Data indicate that CD66c is frequently expressed in CRLF2-positive as well as hypodiploid cases.
Higher cumulative incidence of relapse was found for BCR (show BCR Antibodies)-ABL1 (show ABL1 Antibodies)-like and IKZF1 (show IKZF1 Antibodies)-deleted, but not CRLF2-high, cases relative to remaining BCP (show OPN1SW Antibodies)-ALL cases.
High-cholesterol diet increased TSLPR expression and atherosclerosis. High-dose ticagrelor moderated this trend. It modulated platelet activity and atherosclerosis mediated by TSLPR, potentially through the PI3K/Akt (show AKT1 Antibodies) signal pathway.
Activating thymic stromal lymphopoietin (show TSLP Antibodies) promotes atherosclerosis by inducing Th17/Treg imbalance through TSLPR signaling in a mouse model.
Suggest that Treg defects in ApoE (show APOE Antibodies)(-/-) mice might partially be attributed to the disruption of TSLP (show TSLP Antibodies)-TSLPR-LAP signaling in epithelial cells and dendritic cells.
The structure of the mouse TSLP (show TSLP Antibodies)-mediated signaling complex reveals how TSLP (show TSLP Antibodies) establishes extensive interfaces with its cognate receptor (TSLPR).
TSLPR helps to create a permissive microenvironment for the development and pulmonary metastasis of mammary carcinoma in a mouse model using implanted 4T1 tumour cells.
A previously unrecognized role was found for TSLP (show TSLP Antibodies)/TSLPR signaling in type 2 immunity as an important enhancer for the development of alternately activated macrophages as well as for chemokine (show CCL1 Antibodies) production.
mice deficient in TSLP receptors on LCs abrogated the induction of OVA-specific IgE levels upon epicutaneous OVA sensitization.
Increased susceptibility to autoimmune gastritis in thymic stromal lymphopoietin receptor-deficient mice.
Presence of functional TSLP (show TSLP Antibodies)-specific receptor chain is required for the development of T helper cell type (Th)2 contact hypersensitivity to the hapten fluorescein isothiocyanate (FITC).
Induced homodimerization of receptor chimeras containing the transmembrane and cytoplasmic domains of both human and mouse TSLP (show TSLP Antibodies) receptors is not sufficient for driving cell proliferation.
The protein encoded by this gene is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Two transcript variants encoding different isoforms have been found for this gene.
cytokine receptor-like factor 2
, P2RY8/CRLF2 fusion
, TSLP receptor
, cytokine receptor CRL2 precusor
, cytokine receptor-like 2
, thymic stromal lymphopoietin protein receptor
, thymic stromal lymphopoietin receptor
, thymic stromal-derived lymphopoietin receptor
, cytokine receptor-like molecule 2
, delta 1
, lymphocyte antigen 114
, thymic stromal-derived lymphopoietin, receptor
, transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
, type I cytokine receptor delta 1