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Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Additionally we are shipping CIAO1 Antibodies (64) and CIAO1 Kits (4) and many more products for this protein.
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Data suggest that CIA2B and MMS19 physically interact with C-terminus of viperin/RSAD2; CIAO1 appears to function as primary viperin-interacting protein; CIA2A binds to N-terminus of viperin in CIAO1-, CIA2B-, and MMS19-independent fashion. (CIA2B = metallochaperone CIA2B/FAM96B; MMS19 = transcription factor MMS19; CIAO1 = cytosolic iron-sulfur assembly component 1; CIA2A = metallochaperone CIA2A/Fam96a)
POLE1 is phosphorylated at serine-1940 after DNA damage and interacts with the iron-sulfur complex chaperones CIAO1 and MMS19 (show MMS19 Proteins).
These data suggest that viperin requires CIAO1 for [4Fe-4S] cluster assembly, and acts through an enzymatic, Fe-S cluster- and SAM (show TTN Proteins)-dependent mechanism to inhibit viral RNA synthesis.
CIA2B-CIA1-MMS19 (show MMS19 Proteins) and CIA2A-CIA1 assist different branches of Fe/S protein (show CDSN Proteins) assembly and intimately link this process to cellular iron regulation via IRP1 (show ACO1 Proteins) Fe/S cluster maturation and IRP2 (show IREB2 Proteins) stabilization.
Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.
, WD40 protein Ciao1
, cytosolic iron-sulfur protein assembly 1 homolog (S. cerevisiae)
, cytosolic iron-sulfur protein assembly 1
, probable cytosolic iron-sulfur protein assembly protein CIAO1-like
, WD repeat domain 39
, WD repeat-containing protein 39
, cytosolic iron-sulfur protein assembly 1 homolog
, probable cytosolic iron-sulfur protein assembly protein CIAO1
, probable cytosolic iron-sulfur protein assembly protein ciao1