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The CRTAM gene is upregulated in CD4 (see MIM 186940)-positive and CD8 (see CD8A\; MIM 186910)-positive T cells and encodes a type I transmembrane protein with V and C1-like Ig domains (Yeh et al., 2008 [PubMed 18329370]).[supplied by OMIM, Feb 2009].. Additionally we are shipping CRTAM Proteins (10) and CRTAM Kits (4) and many more products for this protein.
Showing 10 out of 35 products:
Mouse (Murine) Monoclonal CRTAM Primary Antibody for FACS - ABIN2665676
Arase, Takeuchi, Unno, Hirano, Yokosuka, Arase, Saito: Heterotypic interaction of CRTAM with Necl2 induces cell adhesion on activated NK cells and CD8+ T cells. in International immunology 2005
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Mouse (Murine) Monoclonal CRTAM Primary Antibody for ELISA (Detection), ELISPOT (Detection) - ABIN2664609
Galibert, Diemer, Liu, Johnson, Smith, Walzer, Comeau, Rauch, Wolfson, Sorensen, Van der Vuurst de Vries, Branstetter, Koelling, Scholler, Fanslow, Baum, Derry, Yan: Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-I-restricted T-cell-associated molecule. in The Journal of biological chemistry 2005
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Mouse (Murine) Monoclonal CRTAM Primary Antibody for FACS - ABIN2658202
Boles, Barchet, Diacovo, Cella, Colonna: The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM. in Blood 2005
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Mouse (Murine) Monoclonal CRTAM Primary Antibody for FACS, IP - ABIN2662609
Kennedy, Vicari, Saylor, Zurawski, Copeland, Gilbert, Jenkins, Zlotnik: A molecular analysis of NKT cells: identification of a class-I restricted T cell-associated molecule (CRTAM). in Journal of leukocyte biology 2000
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These results reveal that CRTAM is critical to instruct the differentiation of CD4 (show CD4 Antibodies)(+)CTL through the induction of Eomes (show EOMES Antibodies) and CTL-related gene.
CRTAM is negatively regulated by ZEB1 (show ZEB1 Antibodies) in T cells.
Case-control studies reveal malignant mesothelioma risk associated with variants in the SDK1 (show SDK1 Antibodies), CRTAM and RASGRF2 (show RASGRF2 Antibodies) genes.
The cell adhesion molecule (show MCAM Antibodies) Necl-2 (show CADM1 Antibodies) competitively binds the immune receptor CRTAM.
The expression of CRTAM in activated Vgamma9Vdelta2 T cells is quickly downregulated following interaction with Necl-2 (show CADM1 Antibodies) on tumor cells.
Three common variants in the class I MHC-restricted T cell-associated molecule gene were identified that were associated with an increased rate of asthma exacerbations based on the presence of a low circulating vitamin D level.
Results show that CRTAM is a molecule involved in epithelial cell adhesion.
Necl2 (show CADM1 Antibodies)/CRTAM molecular pair could regulate a large panel of cell/cell interactions both within and outside of the immune system
NK cells and T8 cells recognize Necl-2 (show CADM1 Antibodies) through CRTAM, expressed only on activated cells. CRTAM-Necl-2 (show CADM1 Antibodies) interactions promote cytotoxicity of NK cells and IFN-gamma (show IFNG Antibodies) secretion of T8 cells as well as NK cell-mediated rejection of tumors expressing Necl-2 (show CADM1 Antibodies)
CRTAM expression is driven by the JNK (show MAPK8 Antibodies)-AP-1 (show FOSB Antibodies) signaling pathway.
During pathogenic infection, Crtam-Cadm1 (show CADM1 Antibodies) interactions regulate the dynamic equilibrium between newly formed CD4 (show CD4 Antibodies)(+) T cells and their retention in the gut (show GUSB Antibodies).
TCS upregulated the expression of tumor suppressor in lung cancer 1 (TSLC1 (show CADM1 Antibodies)) in 3LL tumor cells and the expression of its ligand, class I-restricted T cell-associated molecule (CRTAM), in effector T cells.
In reciprocal crosses involving alcohol-preferring and alcohol-avoiding mouse strains, Crtam is identified as a candidate gene for alcohol preference.
show that CRTAM has an unexpected constitutive expression in adult thymocytes and, remarkably, it is sustained during all stages of thymocyte development.
CRTAM expression is critical for the accumulation of antigen-specific cytotoxic T lymphocytes and their subsequent proliferation within the draining lymph node.
The CRTAM gene is upregulated in CD4 (see MIM 186940)-positive and CD8 (see CD8A\; MIM 186910)-positive T cells and encodes a type I transmembrane protein with V and C1-like Ig domains (Yeh et al., 2008
cytotoxic and regulatory T-cell molecule
, thymocyte activation and development protein
, thymocyte activation and developmental protein
, cytotoxic and regulatory T cell molecule
, class-I MHC-restricted T cell associated molecule
, cytotoxic and regulatory T-cell molecule-like
, class I MHC restricted T cell associated molecule
, class-I MHC-restricted T-cell-associated molecule
, class I-restricted T cell-associated molecule