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D-2-Hydroxyglutarate Dehydrogenase Proteins (D2HGDH)

D2HGDH encodes D-2hydroxyglutarate dehydrogenase, a mitochondrial enzyme belonging to the FAD-binding oxidoreductase/transferase type 4 family. Additionally we are shipping D2HGDH Antibodies (14) and D2HGDH Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
D2HGDH 98314 Q8CIM3
D2HGDH 301624  
D2HGDH 728294 Q8N465
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Top D2HGDH Proteins at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Yeast Zebrafish His tag   500 μg Log in to see 56 to 66 Days
$962.50
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,371.50
Details
Yeast Arabidopsis thaliana His tag   1 mg Log in to see 56 to 66 Days
$3,393.50
Details
HOST_Escherichia coli (E. coli) REACT_Acidaminococcus fermentans Un-conjugated   50 μg Log in to see 2 to 3 Days
$325.50
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

D2HGDH Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus)

Human ,

More Proteins for D-2-Hydroxyglutarate Dehydrogenase (D2HGDH) Interaction Partners

Human D-2-Hydroxyglutarate Dehydrogenase (D2HGDH) interaction partners

  1. D2HGDH elevates alpha-KG levels via IDH2 (show IDH2 Proteins) expression modulation, influencing histone and DNA methylation (show HELLS Proteins), and HIF1alpha (show HIF1A Proteins) hydroxylation. D2HGDH mutants found in diffuse large B-cell lymphoma are enzymatically inert.

  2. D2HGDH mutation is not associated with glioblastoma.

  3. We did not find evidence for mutations in the genes D2HGDH and L2HGDH (show L2HGDH Proteins) as an alternative mechanism for raised 2-hydroxyglutarate levels in brain tumours

  4. Two novel pathogenic mutations in D-2-hydroxyglutarate dehydrogenase gene in patient with a mild presentation and asymptomatic siblings with D-2-hydroxyglutaric aciduria with a splice error (IVS4-2A-->G) and a missense mutation (c.1315A-->G;p.Asn439Asp).

  5. This enzyme assay will have utility in differentiating patients with 2-hydroxyglutaric aciduria and in assessing the residual activities linked to pathogenic mutations in the D2HGDH gene

D2HGDH Protein Profile

Protein Summary

This gene encodes D-2hydroxyglutarate dehydrogenase, a mitochondrial enzyme belonging to the FAD-binding oxidoreductase/transferase type 4 family. This enzyme, which is most active in liver and kidney but also active in heart and brain, converts D-2-hydroxyglutarate to 2-ketoglutarate. Mutations in this gene are present in D-2-hydroxyglutaric aciduria, a rare recessive neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features.

Gene names and symbols associated with D2HGDH

  • D-2-hydroxyglutarate dehydrogenase (D2hgdh)
  • D-2-hydroxyglutarate dehydrogenase (D2HGDH)
  • D-2-hydroxyglutarate dehydrogenase (d2hgdh)
  • AA408776 protein
  • AA408778 protein
  • AI325464 protein
  • D2HGD protein
  • RGD1307976 protein
  • zgc:158661 protein

Protein level used designations for D2HGDH

D-2-hydroxyglutarate dehydrogenase, mitochondrial

GENE ID SPECIES
98314 Mus musculus
301624 Rattus norvegicus
728294 Homo sapiens
533003 Bos taurus
565889 Danio rerio
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