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Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Additionally we are shipping DPF3 Antibodies (32) and DPF3 Kits (10) and many more products for this protein.
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Activation of DPF3a upon hypertrophic stimuli in cardiac hypertrophy switches cardiac fetal gene expression from being silenced by HEY to being activated by BRG1 (show SMARCA4 Proteins).
Immunohistochemical staining showed that intensive DPF3 staining occurred in proximal anastomosis and the positive staining was hardly observed in stenotic segment in colon specimens from patients with Hirschsprung's disease
These findings provide insights in the STAT5 (show STAT5A Proteins) dependent transcriptional regulation of Dpf3.
by linking RelA (show NFkBP65 Proteins) and p50 (show CD40 Proteins) to the SWI (show SMARCA1 Proteins)/SNF (show SNRPA Proteins) complex, DPF3a/b induces the transactivation of NF-kappaB (show NFKB1 Proteins) target gene promoters in relatively inactive chromatin contexts.
three-dimensional solution structures and biochemical analysis of DPF3b highlight the molecular basis of the integrated tandem PHD (show PDC Proteins) finger, which acts as one functional unit in the sequence-specific recognition of lysine-14-acetylated histone H3 (show HIST3H3 Proteins)
DPF3 adds a further layer of complexity to the BAF (show BANF1 Proteins) complex by representing a tissue-specific anchor between histone acetylations as well as methylations and chromatin remodeling.
Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4 (H3K14ac, H3K9ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac). In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. It thereby probably plays an essential role in heart and skeletal muscle development (By similarity). Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
, zinc finger protein DPF3
, zinc finger protein cer-d4
, BRG1-associated factor 45C
, D4 zinc and double PHD finger family 3
, cerebellum D4
, D4 zinc and double PHD fingers family 3 protein