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DBF4 Homolog (S. Cerevisiae) Proteins (DBF4)

Regulatory subunit for cdc7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Additionally we are shipping DBF4 Antibodies (64) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DBF4 10926 Q9UBU7
DBF4 27214 Q9QZ41
Rat DBF4 DBF4 312046  
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Top DBF4 Proteins at antibodies-online.com

Showing 3 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details

DBF4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for DBF4 Homolog (S. Cerevisiae) (DBF4) Interaction Partners

Human DBF4 Homolog (S. Cerevisiae) (DBF4) interaction partners

  1. The anti-invasive and cell cycle arrest-inducing effects of nitrogen-containing bisphosphonates are not DBF4 mediated in human breast cancer cells.

  2. Dbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint.

  3. bipartite interaction between Cdc7 (show CDC7 Proteins) and Dbf4/ASK subunits facilitates ATP binding and substrate recognition by the Cdc7 (show CDC7 Proteins) kinase.

  4. Dbf4 regulates the Cdc5 Polo-like kinase through a distinct non-canonical binding interaction

  5. Data document the role of DBF4 as a key player in nitrogen-containing bisphosphonate-induced cytotoxicity, thus explaining the effects on the cell-cycle.

  6. The interaction with LEDGF (show PSIP1 Proteins) relieves autoinhibition of Cdc7 (show CDC7 Proteins)-ASK kinase, imposed by the C terminus of ASK.

  7. results suggest that E2F (show E2F1 Proteins) regulates the ASK promoter through an atypical mode of recognition of the target site

  8. The HuDbf4 gene has of 12 exons over a 33-kb region. The MluI cell-cycle box is needed for core promoter activation. The Sp1 upregulator & HES-1 repressor coordinately determine promoter efficiency. Transcription initiations occur at -220, -235 and -245.

  9. Results demonstrate a DNA damage checkpoint that targets Cdc7/Dbf4 protein kinase.

  10. Cdc7-Dbf4 kinase efficiently phosphorylates p150.

DBF4 Protein Profile

Protein Summary

Regulatory subunit for cdc7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Not required during the initiation of DNA replication in egg and during early embryonic development but is required later and throughout development. The complex cdc7-dbf4a phosphorylates mcm2 subunit.

Gene names and symbols associated with DBF4

  • DBF4 homolog (S. cerevisiae) (DBF4)
  • DBF4 homolog B (S. cerevisiae) (DBF4B)
  • DBF4 homolog (S. cerevisiae) (dbf4)
  • DBF4 homolog (S. cerevisiae) (LOC100229596)
  • DBF4 homolog (dbf4)
  • DBF4 homolog (S. cerevisiae) (Dbf4)
  • AA545217 protein
  • Ask protein
  • ChDBF4 protein
  • CHIF protein
  • DBF4 protein
  • DBF4A protein
  • DBF4B protein
  • LOC100229596 protein
  • RGD1305854 protein
  • xdbf4 protein
  • ZDBF1 protein

Protein level used designations for DBF4

DBF4 homolog (S. cerevisiae) , DBF4 homolog B (S. cerevisiae) , activator of S phase kinase , protein DBF4 homolog A , protein DBF4 homolog A-like , DBF4-type zinc finger-containing protein 1 , chiffon homolog A , zinc finger, DBF-type containing 1

GENE ID SPECIES
420536 Gallus gallus
454734 Pan troglodytes
472668 Pan troglodytes
475219 Canis lupus familiaris
480497 Canis lupus familiaris
510916 Bos taurus
705468 Macaca mulatta
771128 Gallus gallus
790361 Bos taurus
799015 Danio rerio
100050313 Equus caballus
100192446 Sus scrofa
100229596 Taeniopygia guttata
100027385 Monodelphis domestica
100339152 Oryctolagus cuniculus
100396428 Callithrix jacchus
100451466 Pongo abelii
100476446 Ailuropoda melanoleuca
100579391 Nomascus leucogenys
398599 Xenopus laevis
10926 Homo sapiens
27214 Mus musculus
312046 Rattus norvegicus
100689339 Cricetulus griseus
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