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The protein encoded by DCTD catalyzes the deamination of dCMP to dUMP, the nucleotide substrate for thymidylate synthase. Additionally we are shipping DCMP Deaminase Antibodies (56) and many more products for this protein.
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Human DCTD Protein expressed in Escherichia coli (E. coli) - ABIN667034
Okazaki, Javle, Tanaka, Abbruzzese, Li: Single nucleotide polymorphisms of gemcitabine metabolic genes and pancreatic cancer survival and drug toxicity. in Clinical cancer research : an official journal of the American Association for Cancer Research 2010
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The protein encoded by this gene catalyzes the deamination of dCMP to dUMP, the nucleotide substrate for thymidylate synthase. The encoded protein is allosterically activated by dCTP and inhibited by dTTP, and is found as a homohexamer. This protein uses zinc as a cofactor for its activity. Two transcript variants encoding different isoforms have been found for this gene.
, dCMP deaminase
, Deoxycytidylate deaminase
, hypothetical protein
, conserved uncharacterised protein