DCN1, Defective in Cullin Neddylation 1, Domain Containing 1 (S. Cerevisiae) Proteins (DCUN1D1)

Part of an E3 ubiquitin ligase complex for neddylation. Additionally we are shipping DCN1, Defective in Cullin Neddylation 1, Domain Containing 1 (S. Cerevisiae) Antibodies (81) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DCUN1D1 54165 Q96GG9
DCUN1D1 114893 Q9QZ73
Rat DCUN1D1 DCUN1D1 310324  
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Top DCN1, Defective in Cullin Neddylation 1, Domain Containing 1 (S. Cerevisiae) Proteins at antibodies-online.com

Showing 10 out of 18 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
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HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days
$319.00
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HOST_Escherichia coli (E. coli) Human His-SUMO Tag   50 μg Log in to see 11 Days
$341.00
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HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 4 Days
$522.50
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HOST_Escherichia coli (E. coli) Human His tag   10 μg Log in to see 15 to 16 Days
$300.00
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HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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HOST_Escherichia coli (E. coli) Human His tag Validation with Western Blot 10 μg Log in to see 12 to 15 Days
$460.85
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
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HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 2 to 3 Days
$364.64
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DCUN1D1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, , ,
Mouse (Murine)

More Proteins for DCN1, Defective in Cullin Neddylation 1, Domain Containing 1 (S. Cerevisiae) (DCUN1D1) Interaction Partners

Human DCN1, Defective in Cullin Neddylation 1, Domain Containing 1 (S. Cerevisiae) (DCUN1D1) interaction partners

  1. The ubiquitin-associated (UBA) domain of SCCRO/DCUN1D1 protein serves as a feedback regulator of biochemical and oncogenic activity.

  2. SCCRO3 functions as a tumor suppressor by antagonizing the neddylation activity of SCCRO

  3. Distinct preferences of UBC12 (show ube2m Proteins) and UBE2F (show UBE2F Proteins) peptides for inhibiting different DCNLs, including the oncogenic DCNL1.

  4. substrate engagement prompts DCNL1 recruitment that facilitates the initiation of CUL2 (show CUL2 Proteins) neddylation and define DCNL1 as a "substrate sensor switch" for ECV activation.

  5. a mono-ubiquitination-mediated mechanism that governs nuclear-cytoplasmic trafficking of hDCNL1, thereby regulating hDCNL1-dependent activation of the cullin-RING E3 ubiquitin ligases in selected cellular compartments.

  6. Loss of SCRO expression in primary adrenocortical carcinoma is associated with worse outcome and may be a marker of progressive dedifferentiation in these tumors.

  7. SCCRO regulates Gli1 (show GLI1 Proteins)--a key regulator of the hedgehog (show SHH Proteins) (HH) pathway.

  8. SCCRO recruits Ubc12 approximately NEDD8 to the CAND1-Cul1-ROC1 complex but that this is not sufficient to dissociate or overcome the inhibitory effects of CAND1 on cullin neddylation

  9. SCCRO-induced invasion involves activation of MMP2 (show MMP2 Proteins) transcription in an AP2 (show GTF3A Proteins)- and p53 (show TP53 Proteins)-dependent manner.

  10. The GG genotype of the DCUN1D1 rs4859147 Single Nucleotide Polymorphism represents a risk factor for the development of frontotemporal lobar degeneration , increasing the risk of about fourfold.

Mouse (Murine) DCN1, Defective in Cullin Neddylation 1, Domain Containing 1 (S. Cerevisiae) (DCUN1D1) interaction partners

  1. Data (including data from studies using cells cultured from knockout mice) suggest that Sccro neddylates Cul3 (show CUL3 Proteins) with Nedd8 (show NEDD8 Proteins), promoting Cul3 (show CUL3 Proteins)/Klhl21 (show KLHL21 Proteins) complex formation and localization of Cul3 (show CUL3 Proteins) during telophase. (Sccro = squamous cell carcinoma-related oncogene (show DCUN1D2 Proteins); Cul3 (show CUL3 Proteins) = cullin 3 (show CUL3 Proteins); Nedd8 (show NEDD8 Proteins) = neural precursor cell expressed, developmentally down-regulated protein 8; Klhl21 (show KLHL21 Proteins) = kelch-like protein 21 (show KLHL21 Proteins))

  2. SCCRO family members cooperatively regulate neddylation and cell proliferation.

  3. The ubiquitin-associated (UBA) domain of SCCRO/DCUN1D1 protein serves as a feedback regulator of biochemical and oncogenic activity.

  4. in the nucleus, SCCRO enhances recruitment of Ubc12 (show ube2m Proteins) to Cul1 (show CUL1 Proteins) to promote neddylation

  5. SCCRO promotes glioma formation and malignant progression.

  6. SCCRO recruits Ubc12 approximately NEDD8 to the CAND1-Cul1-ROC1 complex but that this is not sufficient to dissociate or overcome the inhibitory effects of CAND1 on cullin neddylation

DCN1, Defective in Cullin Neddylation 1, Domain Containing 1 (S. Cerevisiae) (DCUN1D1) Protein Profile

Protein Summary

Part of an E3 ubiquitin ligase complex for neddylation. Required for neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes by enhancing the rate of cullins neddylation. Functions to recruit the NEDD8-charged E2 enzyme to the cullin component. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity).

Gene names and symbols associated with DCUN1D1

  • DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae) (dcun1d1)
  • DCN1-like protein 1 (dcnl1)
  • DCN1, defective in cullin neddylation 1, domain containing 1 (dcun1d1)
  • DCN1, defective in cullin neddylation 1, domain containing 1 (DCUN1D1)
  • DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae) (DCUN1D1)
  • DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae) (Dcun1d1)
  • DCNL1 protein
  • DCUN1L1 protein
  • fd19a01 protein
  • pTes3 protein
  • Rp42 protein
  • SCCRO protein
  • SCRO protein
  • Tes3 protein
  • wu:fd19a01 protein
  • zgc:66414 protein

Protein level used designations for DCUN1D1

DCN1-like protein 1 , DCUN1 domain-containing protein 1 , RP42 homolog , defective in cullin neddylation protein 1-like protein 1 , squamous cell carcinoma related oncogene , squamous cell carcinoma-related oncogene , testis derived transcript 3 , testis-specific protein 3

GENE ID SPECIES
327232 Danio rerio
100301762 Oncorhynchus mykiss
414532 Xenopus laevis
54165 Homo sapiens
424963 Gallus gallus
606979 Canis lupus familiaris
539869 Bos taurus
114893 Mus musculus
310324 Rattus norvegicus
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