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DEK encodes a protein with one SAP domain. Additionally we are shipping DEK Antibodies (54) and DEK Kits (4) and many more products for this protein.
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Results find that DEK binds to transcription start sites with a dual role in activation and repression of highly and ubiquitously expressed genes.
The study identified the DEK oncoprotein as a critical factor that interacts with an essential upstream enhancer element of the EKLF (show KLF1 Proteins) promoter and exerts a positive effect on EKLF (show KLF1 Proteins) levels.
DEK promotes the growth of colorectal cancer and apoptosis
Data show that oncoprotein DEK facilitates cellular proliferation under conditions of DNA replication stress by promoting replication fork progression.
The results show that several leukemia-associated fusion genes cause an increase in DEK protein expression.
DEK expression during normal hematopoiesis did reveal a relationship with specific cell types implicating a distinct function during myeloid differentiation
These data suggest DEK overexpression as a crucial event for the emergence of an aggressive phenotype in colorectal cancer.
Studies demonstrate that DEK overexpression, due in part to Ron (show MST1R Proteins) receptor activation, drives breast cancer progression through the induction of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.
DEK plays an important role in the progression of small cell lung cancer
Results highlight a novel function of DEK as a guardian of chromatin by restricting widespread histone access, and in particular by modulating differential H3.3 loading in specific chromatin areas.
data demonstrate that DEK stimulates HNSCC cellular growth and identify DeltaNp63 as a novel DEK effector
DEK has potent effects on HSCs, HPCs, and hematopoiesis, information of biological and potential clinical interest.
The hallmark of translocation in acutte myeloid leukemiaa is the expression of the DEK/CAN fusion protein.
DEK is a neuroblastoma (show ARHGEF16 Proteins) tumor antigen.
Our conclusion is that DEK could serve as an architectural protein at the promoter or enhancer sites of a subfraction of human genes.
Overexpression of the cellular DEK protein promotes epithelial transformation in vitro and in vivo.
This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene.
, DEK oncogene (DNA binding)
, protein DEK