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anti-DEP Domain Containing 2 (DEPDC2) Antibodies

Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Additionally we are shipping DEP Domain Containing 2 Proteins (4) and DEP Domain Containing 2 Kits (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DEPDC2 80243 Q70Z35
DEPDC2 109294 Q3LAC4
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Top anti-DEP Domain Containing 2 Antibodies at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB   50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Mouse Un-conjugated WB Western Blot analysis of PREX2 expression in transfected 293T cell line by PREX2 MaxPab polyclonal antibody.Lane 1: DEPDC2 transfected lysate(107.69 KDa).Lane 2: Non-transfected lysate. 50 μg Log in to see 9 Days
$430.00
Details
Human Rabbit FITC ELISA, WB   100 μg Log in to see 1 to 2 Days
$572.00
Details
Human Mouse Un-conjugated WB   50 μg Log in to see 8 to 10 Days
$742.50
Details
Human Rabbit Un-conjugated ELISA, WB   100 μg Log in to see 1 to 2 Days
$485.57
Details
Human Mouse Un-conjugated WB   50 μg Log in to see 11 to 16 Days
$553.14
Details

DEPDC2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human
,


Mouse (Murine)



More Antibodies against DEP Domain Containing 2 Interaction Partners

Human DEP Domain Containing 2 (DEPDC2) interaction partners

  1. findings identify PREX2 as a mediator of NRAS (show NRAS Antibodies)-mutant melanoma development that acts through the PI3K (show PIK3CA Antibodies)/PTEN (show PTEN Antibodies)/Akt (show AKT1 Antibodies) pathway to regulate gene expression of a cell cycle regulator (show CDKN2A Antibodies)

  2. second messengers activate the Rac1 signal, which sets in motion a cascade whereby PAKs phosphorylate and negatively regulate PREX2 to decrease Rac1 activation.

  3. PREX2 mutants are likely selected in cancer to escape PTEN (show PTEN Antibodies)-mediated inhibition of invasion.

  4. CXCL9 (show CXCL9 Antibodies) is involved in the invasion ability of hepatocellular carcinoma cells possibly through up-regulation of its potential effector PREX2.

  5. Results demonstrate that miR (show MLXIP Antibodies)-338-3p affects gastric cancer progression through PTEN (show PTEN Antibodies)-AKT (show AKT1 Antibodies) signaling by targeting P-Rex2a in gastric cancer cells

  6. P-REX2 PH-domain-mediated inhibition of PTEN (show PTEN Antibodies) has a role in regulating insulin (show INS Antibodies) sensitivity and glucose homeostasis

  7. MiR (show MLXIP Antibodies)-338-3p affects the PTEN (show PTEN Antibodies)/Akt (show AKT1 Antibodies) pathway by down-regulating PREX2a.

  8. Studies indicate relevance of P-Rex1 (show PREX1 Antibodies) and P-Rex2a, in breast tumorigenesis, and suggest that the exchange factors Vav2 (show VAV2 Antibodies) and Vav3 (show VAV3 Antibodies) play synergistic roles in breast cancer by sustaining tumor growth, neoangiogenesis, and metastasis.

  9. Analysis of whole-genome sequence data identified PREX2 (phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2)--a PTEN (show PTEN Antibodies)-interacting protein and negative regulator of PTEN (show PTEN Antibodies) in breast cancer--as a significantly mutated gene with a mutation frequency of approximately 14% in an independent extension cohort of 107 human melanomas

  10. suggests that aberrant control of PTEN (show PTEN Antibodies) by P-REX2a may represent a key tumorigenic mechanism, in agreement with recent studies supporting the pathological relevance of several other proposed PTEN (show PTEN Antibodies) regulators

Mouse (Murine) DEP Domain Containing 2 (DEPDC2) interaction partners

  1. P-REX2 PH-domain-mediated inhibition of PTEN (show PTEN Antibodies) has a role in regulating insulin (show INS Antibodies) sensitivity and glucose homeostasis

  2. This study demonistrated that the P-Rex2, a GEF (show ARHGEF2 Antibodies) that specifically activates Rac (show AKT1 Antibodies) small GTPases, is expressed in a cell- and synapse-specific manner in the retina.

  3. PI3K/P-Rex/Rac (show AKT1 Antibodies) pathway is required for late phase long-term potentiation in the mouse cerebellum

  4. P-Rex1 (show PREX1 Antibodies) and P-Rex2 are important regulators of Purkinje cell morphology and cerebellar function

DEP Domain Containing 2 (DEPDC2) Antigen Profile

Protein Summary

Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein- coupled receptors and phosphoinositide 3-kinase (By similarity).

Gene names and symbols associated with DEPDC2

  • phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 (PREX2) antibody
  • phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 (Prex2) antibody
  • 6230420N16Rik antibody
  • AI316880 antibody
  • AI553603 antibody
  • C030045D06Rik antibody
  • D430013K02 antibody
  • DEP.2 antibody
  • Depdc2 antibody
  • P-Rex2 antibody

Protein level used designations for DEPDC2

DEP domain-containing protein 2 , PtdIns(3,4,5)-dependent Rac exchanger 2 , phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein , DEP domain containing 2 , ptdIns(3,4,5)-dependent Rac exchanger 2

GENE ID SPECIES
80243 Homo sapiens
109294 Mus musculus
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