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DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) ELISA Kits

Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Additionally we are shipping DHX58 Antibodies (92) and DHX58 Proteins (4) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
DHX58 79132 Q96C10
DHX58 80861 Q99J87
DHX58 303538  
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Top DHX58 ELISA Kits at antibodies-online.com

Showing 8 out of 20 products:

Catalog No. Reactivity Sensitivity Range Quantity Supplier Delivery Price Details
Human 1.41 pg/mL 15.63-1000 pg/mL 96 Tests Log in to see 3 to 4 Days
$390.31
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Rabbit
96 Tests Log in to see 11 to 13 Days
$785.71
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Dog
96 Tests Log in to see 16 to 21 Days
$999.43
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Guinea Pig
96 Tests Log in to see 16 to 21 Days
$999.43
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Monkey
96 Tests Log in to see 16 to 21 Days
$999.43
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Mouse
96 Tests Log in to see 16 to 21 Days
$999.43
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Rabbit
96 Tests Log in to see 16 to 21 Days
$999.43
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Rat
96 Tests Log in to see 16 to 21 Days
$999.43
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More ELISA Kits for DHX58 Interaction Partners

Rainbow Trout (Oncorhynchus mykiss) DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) interaction partners

  1. MDA5 (show IFIH1 ELISA Kits) and LGP2 act as independent positive regulators of the IFN response in fish. the LGP2 variant with a deletion of 54 amino acids at the C terminus acts as a negative regulator for LGP2-elicited antiviral signaling.

Human DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) interaction partners

  1. This review briefly summarizes the RLR system, and focuses on the relationship between LGP2 and MDA5 (show IFIH1 ELISA Kits), describing in detail how these two proteins work together to detect foreign RNA and generate a fully functional antiviral response.

  2. L region antisense RNA of EMCV is a key determinant of innate immunity to the virus and represents an RNA that activates LGP2 associated MDA5 (show IFIH1 ELISA Kits) in virally-infected cells.

  3. LGP2 did not reveal significant single-SNP associations with multiple sclerosis risk.

  4. LGP2 increases the initial rate of MDA5 (show IFIH1 ELISA Kits)-RNA interaction and regulates MDA5 (show IFIH1 ELISA Kits) filament assembly.

  5. Experiments with paramyxovirus V protein-insensitive proteins revealed that the primary outcome of LGP2 interference is suppression of its ability to synergize with MDA5 (show IFIH1 ELISA Kits).

  6. Data show that LGP2 is able to synergize with melanoma differentiation associated gene-5 (mda-5 (show IFIH1 ELISA Kits)) to render cells to induction by poly(I:C), but did not enhance retinoic acid-inducible gene-I (RIG-I (show DDX58 ELISA Kits)) to induce type I interferon (show IFNA ELISA Kits) in response to poly(I:C).

  7. results demonstrate previously unrecognized properties of LGP2 ATP hydrolysis and RNA interaction and provide a mechanistic basis for a positive regulatory role for LGP2 in antiviral signaling

  8. LGP2, a host protein induced during influenza A virus infection, downregulates the host antiviral IFN response

  9. Paramyxovirus 5 V proteins interact with the RNA Helicase LGP2 to inhibit RIG-I (show DDX58 ELISA Kits)-dependent interferon beta (show IFNB1 ELISA Kits) induction.

  10. the present study shows the presence of RIG-1 (show RARRES3 ELISA Kits),MDA-5 (show IFIH1 ELISA Kits), and LGP-2 in the human upper airways, most prominently inthe epithelium.

Mouse (Murine) DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) interaction partners

  1. L region antisense RNA of EMCV is a key determinant of innate immunity to the virus and represents an RNA that activates LGP2 associated MDA5 (show IFIH1 ELISA Kits) in virally-infected cells.

  2. This in vivo study reveals that LGP2 is a major downregulator of the influenza A virus-triggered detrimental inflammatory response.

  3. Enhanced expression of LGP2 suppresses the IFN stimulated genes associated with cytotoxic stress by turning off the expression of IFNbeta

  4. LGP2, a host protein induced during influenza A virus infection, downregulates the host antiviral IFN response

  5. LGP2 promotes an essential prosurvival signal in response to antigen stimulation to confer CD8 (show CD8A ELISA Kits)+ T cell-number expansion and effector functions against divergent RNA viruses, including West Nile virus and lymphocytic choriomeningitis virus.

  6. findings demonstrate a regulatory role for LGP2 in the response to cytosolic DNA, an intracellular bacterial pathogen, and a DNA virus, and provide a plausible mechanistic hypothesis as the basis for this activity

  7. data suggest that LGP2 facilitates viral RNA recognition by RIG-I (show DDX58 ELISA Kits) and MDA5 (show IFIH1 ELISA Kits) through its ATPase (show DNAH8 ELISA Kits) domain.

  8. Lgp2 acts as a negative feedback regulator of antiviral signaling by sequestering double-stranded RNA from retinoic acid-inducible gene-I (RIG-I (show DDX58 ELISA Kits)).

  9. Functional analysis of the human LGP2 ortholog.

Pig (Porcine) DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) interaction partners

  1. Study indicates that DHX58 is an important gene that is associated with the immune response in swine.

Cow (Bovine) DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) interaction partners

  1. Functional analysis of the human LGP2 ortholog.

DHX58 Antigen Profile

Antigen Summary

Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1- dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate.

Gene names and symbols associated with DHX58

  • DEXH (Asp-Glu-X-His) box polypeptide 58 (dhx58) antibody
  • DEXH (Asp-Glu-X-His) box polypeptide 58 (DHX58) antibody
  • Probable ATP-dependent RNA helicase DHX58 (dhx58) antibody
  • DEXH (Asp-Glu-X-His) box polypeptide 58 (Dhx58) antibody
  • B430001I08Rik antibody
  • D11LGP2 antibody
  • D11Lgp2e antibody
  • DHX58 antibody
  • Lgp2 antibody
  • LPG2 antibody
  • MGC82787 antibody
  • RGD1310093 antibody
  • RLR-3 antibody

Protein level used designations for DHX58

DEXH (Asp-Glu-X-His) box polypeptide 58 , probable ATP-dependent RNA helicase DHX58 , probable ATP-dependent RNA helicase DHX58-like , Probable ATP-dependent RNA helicase DHX58 , RIG-I-like receptor 3 , RIG-I-like receptor LGP2 , RLR , RNA helicase LGP2 , ortholog of mouse D11lgp2 , probable ATP-dependent helicase LGP2 , protein D11Lgp2 homolog , RIG-I-like receptor Lgp2 , protein D11Lgp2 , ATP-dependent RNA helicase DHX58

GENE ID SPECIES
444342 Xenopus laevis
742679 Pan troglodytes
100012544 Monodelphis domestica
100066316 Equus caballus
100171435 Pongo abelii
100403680 Callithrix jacchus
100468505 Ailuropoda melanoleuca
100499613 Oncorhynchus mykiss
100566102 Anolis carolinensis
100195148 Salmo salar
79132 Homo sapiens
80861 Mus musculus
303538 Rattus norvegicus
607803 Canis lupus familiaris
100524520 Sus scrofa
508378 Bos taurus
101121528 Ovis aries
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