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DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. Additionally we are shipping DNA Cross-Link Repair 1B, PSO2 Homolog (S. Cerevisiae) Proteins (4) and many more products for this protein.
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Human Polyclonal DCLRE1B Primary Antibody for IHC (p), WB - ABIN651618
Bae, Mukhopadhyay, Liu, Zhang, Tan, Akhter, Liu, Shen, Li, Legerski: Snm1B/Apollo mediates replication fork collapse and S Phase checkpoint activation in response to DNA interstrand cross-links. in Oncogene 2008
Show all 4 references for ABIN651618
Different charge distributions along the DNA binding groove may account for the drastic difference in processivity and DNA digestion efficiency, including that of damaged substrates, between SNM1A (show DCLRE1A Antibodies) and SNM1B.
The SNM1B/APOLLO DNA nuclease (show DCLRE1C Antibodies) functions in resolution of replication stress and maintenance of common fragile site stability.
the N-terminal region of Snm1B forms a complex containing PSF2 (show TAP2 Antibodies) and Mus81 (show MUS81 Antibodies), while the C-terminal region is important for PSF2 (show TAP2 Antibodies)-mediated chromatin association.
The nuclease (show DCLRE1C Antibodies) hSNM1B/Apollo is linked to the Fanconi anemia (show PALB2 Antibodies) pathway via its interaction with FANCP/SLX4 (show BTBD12 Antibodies).
differences in the substrate selectivities of SNM1A (show DCLRE1A Antibodies) and SNM1B are likely to be relevant to their in vivo roles
SNM1B functions epistatically to the central Fanconi anemia (show PALB2 Antibodies) factor, FANCD2 (show FANCD2 Antibodies), in cellular survival after interstrand crosslinks damage and homology-directed repair of DNA double-strand breaks
TRF2 (show TERF2 Antibodies), which binds preferentially to positively supercoiled DNA substrates, together with Apollo, negatively regulates the amount of TOP1 (show TOP1 Antibodies), TOP2alpha, and TOP2beta (show TOP2B Antibodies) at telomeres.
siRNA knockdown of hSNM1B rendered cells sensitive to ionizing radiation, suggesting the possibility of hSNM1B involvement in homologous recombination repair of double-strand breaks arising as intermediates of ICL repair
the C terminus of Snm1B was shown to interact with the TRF (show IL5 Antibodies) homology domain of TRF2 (show TERF2 Antibodies) indicating that Snm1B is likely recruited to the telomere via interaction with the double-stranded telomere-binding protein TRF2 (show TERF2 Antibodies)
SNM1B (Apollo) protein exhibits a 5'-to-3' DNA exonuclease (show EXO1 Antibodies) activity and functions together with TRF2 (show TERF2 Antibodies) to protect telomeres from damage and fusion.
Study documents the combinatorial action of Apollo, POT1b, CST (show CORT Antibodies), and the 5' exonuclease (show EXO1 Antibodies) Exo1 (show EXO1 Antibodies) in postreplicative telomere end processing in mouse cells, clarifying the mechanism by which the telomeric 3' overhang is generated and modulated.
The telomeric protein (show SYCE1 Antibodies) SNM1B/Apollo is required for normal cell proliferation and embryonic development
TRF2 (show TERF2 Antibodies)-bound Apollo functions at replicating telomeres, promoting the maintenance of the telomeric overhang, repressing S phase-specific ATM (show ATM Antibodies) signaling, and protecting leading-end telomeres from fusion.
Apollo null mouse embryo fibroblasts exhibit an increased incidence of G2 chromatid-type fusions involving telomeres created by leading-strand DNA synthesis, reflective of a failure to protect these telomeres after DNA replication.
DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. DCLRE1B is one of several evolutionarily conserved genes involved in repair of interstrand cross-links (Dronkert et al., 2000
5' exonuclease Apollo
, DNA cross-link repair 1B (PSO2 homolog, S. cerevisiae)
, PSO2 homolog
, SNM1 homolog B
, DNA cross-link repair 1B protein