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anti-Damage Specific DNA Binding Protein 1 (DDB1) Antibodies

The protein encoded by DDB1 is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. Additionally we are shipping DDB1 Kits (5) and DDB1 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DDB1 13194 Q3U1J4
DDB1 1642 Q16531
DDB1 64470  
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Top anti-DDB1 Antibodies at antibodies-online.com

Showing 10 out of 86 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Goat Un-conjugated ELISA, WB ABIN184570 (1 µg/ml) staining of NSO lysate (1E5 cells per lane). Detected by western blot using chemiluminescence. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Cow Goat Un-conjugated EIA, WB 20 μg Log in to see 6 to 8 Days
$203.50
Details
Dog Mouse Un-conjugated IF, WB Western blot analysis of DDB1 on a HeLa cell lysate (Human cervical epitheloid carcinoma, ATCC CCL-2.2). Lane 1: 1:500, lane 2: 1:1000, lane 3: 1:2000 dilution of the mouse anti-DDB1 antibody. Immunofluorescence staining of A431 cells (Human epithelial carcinoma, ATCC CRL-1555). 50 μg Log in to see 5 to 6 Days
$205.42
Details
Human Rabbit Un-conjugated EIA, IP, WB Figure. Conjugation pathways for ubiquitin and ubiquitin-like modifiers (UBLs). Most modifiers mature by proteolytic processing from inactive precursors (a, amino acid). Arrowheads point to the cleavage sites. Ubiquitin is expressed either as polyubiquitin or as a fusion with ribosomal proteins. Conjugation requires activating (E1) and conjugating (E2) enzymes that form thiolesters (S) with the modifiers. Modification of cullins by RUB involves SCF(SKP1/cullin-1/F-box protein) /CBC(cullin- 2/elongin B/elonginC) -like E3 enzymes that are also involved in ubiquitination. In contrast to ubiquitin, the UBLs do not seem to form multi-UBL chains. UCRP(ISG15) resembles two ubiquitin moieties linked head-to-tail. Whether HUB1 functions as a modifier is currently unclear. APG12 and URM1 are distinct from the other modifiers because they are unrelated in sequence to ubiquitin. Data contributed by S.Jentsch, see references below. 0.1 mL Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-DDB1 Picoband antibody, IHC(P) IHC(P): Rat Liver Tissue 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB ICC/IF Image DDB1 antibody [C3], C-term detects DDB1 protein at cytoplasm and nucleus by immunofluorescent analysis. Sample: HeLa cells were fixed in ice-cold MeOH for 5 min. Green: DDB1 protein stained by DDB1 antibody [C3], C-term , diluted at 1:500. Blue: Hoechst 33343 staining. WB Image Sample (30 ug of whole cell lysate) A: Neuro2A B: GL261 C: C8D30 7.5% SDS PAGE antibody diluted at 1:1000 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated ICC, IF, WB ICC/IF Image DDB1 antibody [N1N3] detects DDB1 protein at nucleus and cytoplasm by immunofluorescent analysis. Sample: A375 cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: DDB1 protein stained by DDB1 antibody [N1N3] , diluted at 1:500. Blue: Hoechst 33342 staining. WB Image Sample(30 μg of whole cell lysate) A:HeLa S3 , B:Raji, 7.5% SDS PAGE antibody diluted at 1:1000 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated ICC, IF, IP, IHC (p), WB IHC-P Image Immunohistochemical analysis of paraffin-embedded Cal27 Xenograft , using DDB1, antibody at 1:500 dilution. WB Image Sample (50 ug of whole cell lysate) A: Mouse brain 5% SDS PAGE antibody diluted at 1:5000 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated IHC (p), IP, ELISA, WB Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with DDB1 antibody ABIN218512 at 1:500 followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μL Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 14 Days
$369.79
Details

DDB1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine)
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Rat (Rattus)
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Top referenced anti-DDB1 Antibodies

  1. Cow (Bovine) Polyclonal DDB1 Primary Antibody for EIA, WB - ABIN782865 : Li, Robert, van Breugel, Strubin, Zheng: A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery. in Nature structural & molecular biology 2010 (PubMed)
    Show all 5 references for ABIN782865

  2. Human Polyclonal DDB1 Primary Antibody for EIA, IP - ABIN117954 : Shiyanov, Hayes, Donepudi, Nichols, Linn, Slagle, Raychaudhuri: The naturally occurring mutants of DDB are impaired in stimulating nuclear import of the p125 subunit and E2F1-activated transcription. in Molecular and cellular biology 1999 (PubMed)
    Show all 5 references for ABIN117954

  3. Dog (Canine) Monoclonal DDB1 Primary Antibody for IF, WB - ABIN968852 : Dualan, Brody, Keeney, Nichols, Admon, Linn: Chromosomal localization and cDNA cloning of the genes (DDB1 and DDB2) for the p127 and p48 subunits of a human damage-specific DNA binding protein. in Genomics 1996 (PubMed)
    Show all 4 references for ABIN968852

More Antibodies against DDB1 Interaction Partners

Mouse (Murine) Damage Specific DNA Binding Protein 1 (DDB1) interaction partners

  1. These studies identify CUL4-DDB1 complex as a novel post-translational regulator of stem and progenitor maintenance and differentiation.

  2. uncovered a novel biological role for CUL4A (show CUL4A Antibodies)-DDB1-CDT2 E3 ligase that regulates molecular circadian behaviors via promoting ubiquitination-dependent degradation of CRY1 (show CRY1 Antibodies)

  3. UCH-L1 disrupts a complex between the DDB1-CUL4 ubiquitin ligase complex.

  4. In a constructive process, pM27 recruits DDB1 to exploit ubiquitin ligase (show RNF123 Antibodies) complexes catalyzing the obstruction of the STAT2 (show STAT2 Antibodies)-dependent antiviral state of cells to permit viral replication.

  5. Hepatocyte-specific deletion of DDB1 induces liver regeneration and tumorigenesis.

  6. These results indicate that DDB1 plays an essential role in maintaining viability and genomic integrity of dividing cells.

  7. DDB1 plays an important role in development by controlling levels of cell cycle regulators and thereby maintaining genomic stability.

Human Damage Specific DNA Binding Protein 1 (DDB1) interaction partners

  1. Our data are consistent with the idea that the CUL4A (show CUL4A Antibodies)/B-DDB1-CRBN (show CRBN Antibodies) complex catalyses the polyubiquitination and thus controls the degradation of CLC-1 (show CLCN1 Antibodies) channels.

  2. These results revealed a novel role of DDB in H3K56Ac deacetylation during early step of NER (show NR1H2 Antibodies) and the existence of active functional cross-talk between DDB-mediated damage recognition and H3K56Ac deacetylation.

  3. The identification of Vpr mutants which associate with DCAF1 (show VPRBP Antibodies) but only poorly with DDB1 suggests that DCAF1 (show VPRBP Antibodies) is necessary but is not sufficient for the Vpr association with DDB1-containing E3 ligase complex.

  4. Data support a model wherein DDB1 and DDB2 (show DDB2 Antibodies) cooperate to repress Bcl-2 (show BCL2 Antibodies) transcription. DDB2 (show DDB2 Antibodies) recognizes and binds to the Bcl-2 (show BCL2 Antibodies) P1 promoter, and HDAC1 (show HDAC1 Antibodies) is recruited through the DDB1 subunit associated with DDB2 (show DDB2 Antibodies) to deacetylate histone H3K9.

  5. The study presents the crystal structure of human CRBN (show CRBN Antibodies) bound to DDB1 and the drug lenalidomide.

  6. CUL4A (show CUL4A Antibodies)-DDB1-Rbx1 E3 ligase controls the quality of the PTS2 receptor (show PEX7 Antibodies) Pex7p.

  7. structures of the DDB1-CRBN (show CRBN Antibodies) complex bound to thalidomide, lenalidomide and pomalidomide

  8. In the three intrinsically IMiD-resistant cell lines that clearly express detectable levels of cereblon (show CRBN Antibodies), the absence of CRBN (show CRBN Antibodies) and DDB1 mutations suggest that potential cereblon (show CRBN Antibodies)-independent mechanisms of resistance exist

  9. UV-DDB examines sites on DNA in discrete steps before forming long-lived, nonmotile UV-DDB dimers (DDB1-DDB2 (show DDB2 Antibodies))2 at sites of damage.

  10. p73 (show TP73 Antibodies) interacts with the CDL4A complex by binding directly to DDB1. The CDL4A complex is able to monoubiquitylate p73 (show TP73 Antibodies), negatively affecting its transcriptional function.

DDB1 Antigen Profile

Protein Summary

The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins.

Gene names and symbols associated with DDB1

  • damage specific DNA binding protein 1 (Ddb1) antibody
  • damage-specific DNA binding protein 1, 127kDa (DDB1) antibody
  • damage-specific DNA binding protein 1, 127kDa (Ddb1) antibody
  • 127kDa antibody
  • AA408517 antibody
  • DDBA antibody
  • p127-Ddb1 antibody
  • UV-DDB1 antibody
  • XAP1 antibody
  • XPCE antibody
  • XPE antibody
  • XPE-BF antibody

Protein level used designations for DDB1

DDB p127 subunit , DNA damage-binding protein 1 , DNA repair protein , UV-damaged DNA-binding factor , damage-specific DNA-binding protein 1 , damage-specific DNA-binding protein, DNA repair , damaged-DNA recognition protein 1 , DNA damage-binding protein a , HBV X-associated protein 1 , UV-DDB 1 , UV-damaged DNA-binding protein 1 , XAP-1 , XPE-binding factor , xeroderma pigmentosum group E-complementing protein , damage specific DNA binding protein 1

GENE ID SPECIES
13194 Mus musculus
1642 Homo sapiens
64470 Rattus norvegicus
Selected quality suppliers for anti-DDB1 (DDB1) Antibodies
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