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The protein encoded by DOCK2 belongs to the CDM protein family. Additionally we are shipping and many more products for this protein.
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Human Polyclonal DOCK2 Primary Antibody for WB - ABIN2784753
Kwofie, Skowronski: Specific recognition of Rac2 and Cdc42 by DOCK2 and DOCK9 guanine nucleotide exchange factors. in The Journal of biological chemistry 2008
Identify DOCK2 as a novel regulator for smooth muscle cell phenotypic modulation and vascular lesion formation after vascular injury.
DOCK2 is critical for graft facilitating cells to maintain its immunomodulatory function.
together with DOCK5 (show Dock5 Antibodies) contributes to chemotaxis, reactive oxygen species production, and extracellular trap formation
the IRF5 (show IRF5 Antibodies) (-/-) mice with the DOCK2 mutation have higher serum levels of IgG1 and lower levels of IgG2b, IgG2a/c and IgG3 than IRF5 (show IRF5 Antibodies) (-/-) mice without the DOCK2 mutation, suggesting that the DOCK2 mutation confers additional Th2-type effects.
findings reveal a previously unknown, nonredundant role for Elmo1 (show ELMO1 Antibodies) in controlling Dock2 levels and Dock2-dependent T cell migration in primary lymphocytes.
DOCK2, an atypical guanine nucleotide exchange factor (show ARHGEF12 Antibodies) for Rac (show AKT1 Antibodies), plays a key role in NK cell-mediated cytotoxicity.
in vivo results presented here suggest DOCK2 contributes to amyloid beta plaque burden via regulation of microglial innate immune function and may represent a novel therapeutic target for Alzheimer's disease
Results thus indicate that DOCK2 dimerization is functionally important under the physiological condition where only limited amounts of DOCK2 and Rac (show AKT1 Antibodies) are localized to the plasma membrane.
A spontaneous genomic duplication and frameshift mutation in the guanine exchange factor dedicator of cytokinesis 2 (Dock2) that has arisen in at least a subset of circulating Irf5 (show IRF5 Antibodies)(-/-) mice and inadvertently been bred to homozygosity.
ASC shapes adaptive immunity independently of inflammasomes by modulating Dock2-dependent Rac activation and actin polymerization in DCs and lymphocytes.
Autosomal recessive DOCK2 deficiency is a new mendelian disorder with pleiotropic defects of hematopoietic and nonhematopoietic immunity.
DOCK2 is required for the normal T and B cell migration and signal transduction. (Review)
DOCK2 mutations are associated with esophageal adenocarcinoma.
The C-terminal Pro-rich tail of ELMO1 (show ELMO1 Antibodies) winds around the Src (show SRC Antibodies)-homology 3 domain of DOCK2 to form an intermolecular 5-helix bundle. The entire regions of both DOCK2 a& ELMO1 (show ELMO1 Antibodies) assemble to create a rigid structure required for the DOCK2 & ELMO1 (show ELMO1 Antibodies) binding.
Our results show CXCL13 (show CXCL13 Antibodies)-mediated PCa (show FLVCR1 Antibodies) cell invasion requires Akt (show AKT1 Antibodies) and ERK12 activation and suggests a new role for DOCK2 in proliferation of hormone-refractory CXCR5 (show CXCR5 Antibodies)-positive PCa (show FLVCR1 Antibodies) cells.
prostate cancer cell lines differentially express phosphoinositide-3 kinase (PI3K (show PIK3CA Antibodies)) catalytic subunit isoforms and dedicator of cytokinesis 2
This is the first report to clarify the prominent role of DOCK2 in hematopoietic malignancy.
DOCK2 mediates T cell receptor-induced activation of Rac2 (show RAC2 Antibodies) and IL-2 (show IL2 Antibodies) transcription in jurkat cells
DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines
The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells, predominantly in the peripheral blood leukocytes, and is involved in remodeling of the actin cytoskeleton required for lymphocyte migration, through the activation of RAC. Mice lacking this gene show a severe impairment in the migration and homing of lymphocytes. These mutant mice also exhibited long-term survival of allografts, suggesting that this gene may be a target for controlling transplant rejection.
dedicator of cytokinesis 2
, dedicator of cytokinesis protein 2-like
, dedicator of cytokinesis protein 2
, dedicator of cyto-kinesis 2