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Defensin, alpha 3, Neutrophil-Specific Proteins (DEFa3)

Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. Additionally we are shipping DEFa3 Antibodies (39) and DEFa3 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DEFa3 613253  
Mouse DEFa3 DEFa3 13237 P28310
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Top DEFa3 Proteins at

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Human Cells Human Fc Tag 100 μg Log in to see 16 Days
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 16 Days

DEFa3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,

More Proteins for Defensin, alpha 3, Neutrophil-Specific (DEFa3) Interaction Partners

Human Defensin, alpha 3, Neutrophil-Specific (DEFa3) interaction partners

  1. High HNP3 expression is associated with IgA Nephropathy.

  2. RTD-1 reduced the secretion of tumor necrosis factor-alpha (TNF-alpha (show TNF Proteins)), interleukin (IL)-1beta (show IL1B Proteins), and IL-8 (show IL8 Proteins) in lipopolysaccharide (LPS (show IRF6 Proteins))-stimulated human blood monocytes and THP-1 macrophages

  3. Elevated DEFA3 levels in diabetes are independent of DEFA3 copy numbers.

  4. DEFA3 encodes an antibacterial peptide that is bacteriocidal against S. aureus, E. coli, and P. aeruginosa.

  5. A decrease in salivary HNP 1 (show DEFA1 Proteins)-3 levels might be a biological factor for predisposition to oral ulcers in patients with Behcet disease and oral infection in healthy patients.

  6. Results indicate that the gene expression of DEFA 1/3 and 4 was significantly increased in all tumours - except for a significant decrease of DEFA 4 gene expression in pleomorphic adenomas.

  7. DEFA1A3 copy numbers did not differ significantly between systemic lupus erythematosus patients and controls. DEFA1A3 copy numbers ranged from 3 to 11 in Han Chinese in Beijing and 4 to 16 in Japanese in Tokyo.

  8. alpha-Defensin (show DEF Proteins) (DEFA3)was the third most differentially overexpressed gene and may be related to the onset of Bell's palsy and Ramsay Hunt Syndrome.

  9. a high DEFA1A3 copy number might be important in hindering the normal inflammatory response in CD, particularly colonic CD.

  10. Increased levels of human neutrophil peptides 1, 2, and 3 in peritoneal fluid of patients with endometriosis: association with neutrophils, T cells and IL-8 (show IL8 Proteins).

Mouse (Murine) Defensin, alpha 3, Neutrophil-Specific (DEFa3) interaction partners

  1. MMP-7 (show MMP7 Proteins)-dependent procryptdin activation in vivo provides mouse Paneth cells with functional peptides for apical secretion into the small intestine lumen

  2. cryptdin 3 forms anion-selective channels on the cytoplasmic membrane of HEK (show EPHA3 Proteins) cells and that the kinetics of one such channel are affected by its interaction with other such channels.

DEFa3 Protein Profile

Protein Summary

Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 3, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 1 by only one amino acid. This gene and the gene encoding defensin, alpha 1 are both subject to copy number variation.

Gene names and symbols associated with DEFa3

  • defensin, alpha 3, neutrophil-specific (DEFA3)
  • alpha-defensin 1A (MNP1A)
  • defensin, alpha 1 and alpha 3, variable copy number locus (DEFA1A3)
  • defensin, alpha, 3 (Defa3)
  • DEF3 protein
  • DEFA1 protein
  • DEFA3 protein
  • Defa27 protein
  • Defcr-3 protein
  • Defcr3 protein
  • DEFT1P protein
  • HNP-3 protein
  • HNP3 protein
  • HP-3 protein
  • HP3 protein

Protein level used designations for DEFa3

neutrophil defensin 3 , Paneth cell-specific alpha-defensin 3 , alpha-defensin 3, neutrophil-specific , Neutrophil defensin 1 , Neutrophil defensin 3 , RMAD-1 , RMAD-3 , RMAD-8 , neutrophil defensin 8 , defensin 3, neutrophil-specific , neutrophil peptide 3 , alpha-defensin 3 , defensin, alpha, 27 , defensin-related cryptdin-3

100307025 Equus caballus
574196 Macaca mulatta
613253 Homo sapiens
1668 Homo sapiens
13237 Mus musculus
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