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Defensin, alpha 5, Paneth Cell-Specific Proteins (DEFA5)

Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. Additionally we are shipping Defensin, alpha 5, Paneth Cell-Specific Antibodies (40) and Defensin, alpha 5, Paneth Cell-Specific Kits (39) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat DEFA5 DEFA5 290856  
DEFA5 1670 Q01523
Mouse DEFA5 DEFA5 13239  
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Top Defensin, alpha 5, Paneth Cell-Specific Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Escherichia coli (E. coli) Human His tag,S tag 100 μg Log in to see 11 to 13 Days
$767.80
Details
Yeast Pan troglodytes His tag   1 mg Log in to see 56 to 66 Days
$2,097.33
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$936.27
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

DEFA5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,

More Proteins for Defensin, alpha 5, Paneth Cell-Specific (DEFA5) Interaction Partners

Human Defensin, alpha 5, Paneth Cell-Specific (DEFA5) interaction partners

  1. a moderately active linear peptide derived from the alpha-defensin (show DEF Proteins) HD5 can be engineered to enhance antimicrobial activity almost comparable to the native peptide.

  2. The study used ion mobility coupled to mass spectrometry to track the structural changes in HD-5 upon disulfide bond reduction.

  3. The study reports the screening of human defensin 5 against the Keio Collection of E. coli strains and shows how this important hostdefense peptide kills bacteria and how bacteria protect themselves against the attack from the human host.

  4. Authors show that although NOD2 by itself can slightly up-regulate expression of HD5 and HD6 (show DEFA6 Proteins), it can strongly down-regulates their expression during differentiation of the Paneth cell lineage mainly by inhibiting activation of the MAPK (show MAPK1 Proteins) pathway.

  5. These data support a model in which HD5 prevents furin (show FURIN Proteins) from accessing human papillomavirus 16 L2 by occluding the furin (show FURIN Proteins) cleavage site via direct binding to the viral capsid.

  6. Enteric alpha-defensin (show DEF Proteins) HD5 and beta-defensin (show DEFB1 Proteins) hBD2 (show DEFB4 Proteins) shared similar toxin-unfolding effects with HNP1 (show DEFA1 Proteins), albeit to different degrees.

  7. our results highlight the potential contribution of altered alpha-defensin (show DEF Proteins) HD-5 expression in the formation of a viral/tumour-permissive environment in high-risk HPV infection and progression to cancer of the uterine cervix

  8. DEFA5 displays antimicrobial activity against E. coli, E. aerogenes, B. cereus, and S. aureus.

  9. Data indicate that cellular effects of defensin 5 involve interactions with the extra-cellular domain of tumor necrosis Factor (show TNF Proteins) 1.

  10. Anti-HIV activity of human defensin 5 in primary CD4 (show CD4 Proteins)+ T cells under serum-deprived conditions is a consequence of defensin (show DEF Proteins)-mediated cytotoxicity.

Mouse (Murine) Defensin, alpha 5, Paneth Cell-Specific (DEFA5) interaction partners

  1. Data show that DEFA5-expressing mice had striking losses of segmented filamentous bacteria and fewer interleukin 17 (IL-17 (show IL17A Proteins))-producing lamina propria T cells.

Defensin, alpha 5, Paneth Cell-Specific (DEFA5) Protein Profile

Protein Summary

Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several of the alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 5, is highly expressed in the secretory granules of Paneth cells of the ileum.

Gene names and symbols associated with DEFA5

  • defensin, alpha 5, Paneth cell-specific (DEFA5)
  • alpha-defensin 1A (MNP1A)
  • defensin alpha 24 (Defa24)
  • defensin, alpha 5, Paneth cell-specific (Defa5)
  • defensin, alpha, 5 (Defa5)
  • DEF5 protein
  • Defa protein
  • DEFA1 protein
  • DEFA5 protein
  • Defa29 protein
  • Defcr4 protein
  • Defcr5 protein
  • Defcr24 protein
  • Defcr29 protein
  • defensin-5 protein
  • defensin 6 protein
  • defensin 7 protein
  • HD-5 protein
  • Rd5 protein

Protein level used designations for DEFA5

alpha-defensin 5, Paneth cell-specific , Paneth cell-specific alpha-defensin 5 , Neutrophil defensin 1 , Neutrophil defensin 3 , RMAD-1 , RMAD-3 , RMAD-8 , neutrophil defensin 8 , RD-5 , alpha-defensin, 24 , defensin 5 , defensin related cryptdin 24 , defensin related cryptdin 4 , defensin, alpha, 24 , enteric defensin alpha 5 , HD5(20-94) , defensin, alpha 5, preproprotein , defensin-5 , defensin NP-2 , neutrophil antibiotic peptide NP-1 , neutrophil antibiotic peptide NP-2 , neutrophil defensin 1 , neutrophil defensin 2 , ratNP-1 , ratNP-2 , defensin, alpha 1 , alpha-defensin 5 , defensin, alpha, 29 , defensin-related cryptdin-5

GENE ID SPECIES
100307028 Equus caballus
574196 Macaca mulatta
290856 Rattus norvegicus
1670 Homo sapiens
286995 Rattus norvegicus
463972 Pan troglodytes
13239 Mus musculus
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