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Defensin, alpha 6, Paneth Cell-Specific Proteins (DEFA6)

Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. Additionally we are shipping Defensin, alpha 6, Paneth Cell-Specific Antibodies (29) and Defensin, alpha 6, Paneth Cell-Specific Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat DEFA6 DEFA6 613223  
DEFA6 1671 Q01524
Mouse DEFA6 DEFA6 13240 P50704
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Top Defensin, alpha 6, Paneth Cell-Specific Proteins at antibodies-online.com

Showing 2 out of 2 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

DEFA6 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

More Proteins for Defensin, alpha 6, Paneth Cell-Specific (DEFA6) Interaction Partners

Human Defensin, alpha 6, Paneth Cell-Specific (DEFA6) interaction partners

  1. Paneth cell alpha-defensin 6 is an antimicrobial peptide (show cAMP Proteins).

  2. Native HD-6 readily self-assembles into elongated fibrils observable by transmission electron microscopy, agglutinates both Gram-negative and -positive bacteria, and prevents the Listeria monocytogenes from invading cultured cells.

  3. Authors show that although NOD2 by itself can slightly up-regulate expression of HD5 (show DEFA5 Proteins) and HD6, it can strongly down-regulates their expression during differentiation of the Paneth cell lineage mainly by inhibiting activation of the MAPK (show MAPK1 Proteins) pathway.

  4. In the meta-analysis, DEFA6 rs13275170 and DEFB1 (show DEFB1 Proteins) rs2738169 had both a 1.3-fold increased odds ratio for gastric cancer.

  5. study reports that HD6 affords protection against invasion by enteric bacterial pathogens in vitro and in vivo; after stochastic binding to bacterial surface proteins, HD6 undergoes ordered self-assembly to form fibrils and nanonets that surround and entangle bacteria

  6. Defensin alpha 6 (DEFA 6) may have a role in adenoma but not in progression to colon carcinoma

  7. defensin (show DEF Proteins) alpha6 is highly expressed in colon cancer cell lines

  8. Crystal structure of HD6.

  9. Human enteric defensin (show DEF Proteins) (HD)-5 (show DEFA5 Proteins) and HD-6 were detected in Paneth cells, which are observed in the gastric metaplastic mucosa as well as small intestinal epithelia.

Defensin, alpha 6, Paneth Cell-Specific (DEFA6) Protein Profile

Protein Summary

Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 6, is highly expressed in the secretory granules of Paneth cells of the small intestine, and likely plays a role in host defense of human bowel.

Gene names and symbols associated with DEFA6

  • defensin, alpha 6, Paneth cell-specific (DEFA6)
  • defensin alpha 6 (Defa6)
  • defensin, alpha 6 (DEFA6)
  • defensin, alpha, 6 (Defa6)
  • DEF6 protein
  • DEFA6 protein
  • Defcr6 protein
  • HD-6 protein

Protein level used designations for DEFA6

defensin, alpha 6, Paneth cell-specific , alpha-defensin 6, Paneth cell-specific , Paneth cell-specific alpha-defensin 6 , alpha-defensin 6 , defensin-6 , defensin 6 , alpha-defensin 6/12 , alpha-defensin, 6 , cryptdin-2 , defensin related cryptdin 6 , defensin-related cryptdin-6/12

GENE ID SPECIES
717000 Macaca mulatta
100307029 Equus caballus
613223 Rattus norvegicus
619354 Pan troglodytes
1671 Homo sapiens
13240 Mus musculus
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