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anti-Deoxyribonuclease I (DNASE1) Antibodies

DNASE1 encodes a member of the DNase family. Additionally we are shipping Deoxyribonuclease I Kits (65) and Deoxyribonuclease I Proteins (24) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DNASE1 1773 P24855
DNASE1 25633 P21704
DNASE1 13419 P49183
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Top anti-Deoxyribonuclease I Antibodies at antibodies-online.com

Showing 10 out of 81 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-DNASE1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1... WB Suggested Anti-DNASE1  Antibody Titration: 0.2-1 µg/mL ELISA Titer:... 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from HT-29 cells, using DNL1 Antibod... Immunohistochemistry analysis of paraffin-embedded human brain tissue,... 100 μg Log in to see 2 to 3 Days
$275.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB IHC-P Image DNase I antibody [N1C3] detects DNase I protein at cytopla... WB Image Sample (30 ug of whole cell lysate) A: MOLT4 , 10% SDS PAGE a... 100 μL Log in to see 2 to 3 Days
$358.60
Details
Cow Rabbit Un-conjugated ELISA   100 μg Log in to see 2 to 3 Days
$369.00
Details
Cow Rabbit Un-conjugated EIA, WB   2 mL Log in to see 6 to 8 Days
$1,435.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Cow Rabbit Un-conjugated IP, ELISA, WB   1 mL Log in to see 3 to 4 Days
$182.50
Details
Cow Mouse Un-conjugated ELISA, WB Western Blot testing of anti-bovine DNaseI monoclonal antibody (6D5). ... 100 μg Log in to see 7 to 9 Days
$342.00
Details
Human Rabbit Un-conjugated IHC (p), WB Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Log in to see 8 to 10 Days
$451.00
Details

DNASE1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human , , , ,
,
Rat (Rattus) , , , ,

Mouse (Murine) , , , ,

More Antibodies against Deoxyribonuclease I Interaction Partners

Cow (Bovine) Deoxyribonuclease I (DNASE1) interaction partners

  1. Specificity in DNA-DNase I interaction is mediated by DNA flexibility, which influences the induced-fit transitions required to form productive complexes.

Human Deoxyribonuclease I (DNASE1) interaction partners

  1. TNF-alpha (show TNF Antibodies) amplifies DNaseI expression in renal tubular cells while IL-1beta (show IL1B Antibodies) promotes nuclear DNaseI translocation in inactive form in lupus nephritis.

  2. HumDN1 polymorphisms were examined in blood of 11 worldwide populations by polymerase chain reaction. 15 genotypes were found leading to the conclusion that HumDN1 variable no. tandem repeats are ethnic group specific.

  3. Val66Met in the BDNF (show BDNF Antibodies) gene and two SNPs, Fokl and Apal, in the VDR (show CYP27B1 Antibodies) gene may potentially be associated with DED (show AATF Antibodies). Additionally, the association between DED (show AATF Antibodies) and Val66Met may vary by depression status.

  4. In conclusion, elevated DNase I in diabetes may be related to pancreatic injury and could be one of the causes that induce diabetes.

  5. Our results indicate that increased DNASE1 expression is common to both SLE and RA, while DNase1 reduction activity is specific to SLE.

  6. Characterization of the nonsynonymous single-nucleotide polymorphism variants of human DNASE1.

  7. DNase I activity in systemic lupus erythematosus patients was lower than in healthy controls

  8. DNAse I Q222R polymorphism is a potential genetic risk factor for systemic lupus erythematosus in South Indian Tamils. In addition, the mutant allele confers a significant risk for lupus nephritis.

  9. Single nucleotide polymorphisms in the DNASE1 is associated with autoimmune diseases.

  10. a downregulation of the DNASE1 mRNA expression in patients with autoimmune thyroid disease. This might result in degrading less DNA from dying cells, thereby promoting the development of thyroid autoimmunity.

Mouse (Murine) Deoxyribonuclease I (DNASE1) interaction partners

  1. HMGN1 (show HMGN1 Antibodies) binds to CpG island-containing promoters and affects the organization of nucleosomes, DNase I hypersensitivity, and the transcriptional profile of mouse embryonic stem cells and neural progenitors.

  2. Early mesangial nephritis initiates a cascade of inflammatory signals that lead to up-regulation of Trap1 (show TRAP1 Antibodies) and a consequent down-regulation of renal DNaseI by transcriptional interference.

  3. silencing of renal DNaseI gene expression initiates a cascade of inflammatory signals including activation of Toll (show TLR4 Antibodies) like receptors and Clec4e (show CLEC4E Antibodies), leading to progression of both murine and human lupus nephritis

  4. Data show that deletion of DNaseI hypersensitive sites does not have an obvious impact on the IgH locus or B cell development.

  5. Reduction in renal Dnase1 expression and activity is limited to mice and SLE patients with signs of membranoproliferative nephritis, and may be a critical event in the development of severe forms of lupus nephritis.

  6. A conserved sequence located 211 kilobases upstream of class II major histocompatibility complex transcriptional coactivator (CIITA (show CIITA Antibodies)) promoter III is hypersensitive to DNase I.

  7. The impact of antibodies to dsDNA, renal Dnase1 and matrix metalloprotease (show ADAMTS7 Antibodies) (MMP) mRNA levels and enzyme activities on early and late events in murine lupus nephritis, was determined.

  8. serum Dnase1 in cooperation with the plasminogen (show PLG Antibodies) system guarantees a fast and effective breakdown of chromatin during necrosis by the combined cleavage of DNA as well as of DNA binding proteins.

  9. DNase I is essential for kidney injury induced by cisplatin

  10. Results describe chromatin disposal during necrosis and the involvement of Deoxyribonuclease 1 in this process with respect to its possible role in the prevention of anti-nuclear auto-immunity.

Horse (Equine) Deoxyribonuclease I (DNASE1) interaction partners

  1. Purification and characterization of equine DNase 1 was done; it was confirmed to be of the parotid-type.

Deoxyribonuclease I (DNASE1) Antigen Profile

Protein Summary

This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Gene names and symbols associated with DNASE1

  • deoxyribonuclease I (dnase1-A) antibody
  • DNase I (LOC397802) antibody
  • deoxyribonuclease I (dnase1) antibody
  • deoxyribonuclease I (Mmc1_2065) antibody
  • deoxyribonuclease I (CpipJ_CPIJ011184) antibody
  • deoxyribonuclease I (CpipJ_CPIJ011185) antibody
  • deoxyribonuclease I (CpipJ_CPIJ011186) antibody
  • deoxyribonuclease I (CpipJ_CPIJ011187) antibody
  • deoxyribonuclease I (CpipJ_CPIJ011190) antibody
  • deoxyribonuclease I (CpipJ_CPIJ017803) antibody
  • Deoxyribonuclease I (Desal_1409) antibody
  • DNase I (endA) antibody
  • deoxyribonuclease I (Mpet_1024) antibody
  • deoxyribonuclease I (Mmc1_1309) antibody
  • deoxyribonuclease I (Mmc1_2835) antibody
  • deoxyribonuclease I (Pnap_4374) antibody
  • deoxyribonuclease I (Pnap_0624) antibody
  • deoxyribonuclease I (Metev_0455) antibody
  • deoxyribonuclease I (Plabr_0631) antibody
  • deoxyribonuclease I (DNASE1) antibody
  • deoxyribonuclease I (Dnase1) antibody
  • AI788650 antibody
  • dnase1-A antibody
  • DNaseI antibody
  • Dnl1 antibody
  • DRNI antibody
  • LOC397802 antibody
  • zgc:92440 antibody

Protein level used designations for DNASE1

deoxyribonuclease I , DNase I , deoxyribonuclease-1 , Deoxyribonuclease I , DNase I, lysosomal , Dornase alfa , human urine deoxyribonuclease I

GENE ID SPECIES
394359 Xenopus laevis
397802 Xenopus laevis
436947 Danio rerio
4481328 Magnetococcus marinus MC-1
6043536 Culex quinquefasciatus
6043537 Culex quinquefasciatus
6043538 Culex quinquefasciatus
6043539 Culex quinquefasciatus
6043542 Culex quinquefasciatus
6051839 Culex quinquefasciatus
8093039 Desulfovibrio salexigens DSM 2638
8218482 Escherichia coli O157:H7 str. TW14359
9743488 Methanoplanus petrolearius DSM 11571
4482665 Magnetococcus marinus MC-1
4483001 Magnetococcus marinus MC-1
4685389 Polaromonas naphthalenivorans CJ2
4688182 Polaromonas naphthalenivorans CJ2
9346074 Methanohalobium evestigatum Z-7303
10238020 Planctomyces brasiliensis DSM 5305
282217 Bos taurus
1773 Homo sapiens
25633 Rattus norvegicus
13419 Mus musculus
100009513 Oryctolagus cuniculus
100718441 Cavia porcellus
397051 Sus scrofa
395725 Gallus gallus
100034219 Equus caballus
101122154 Ovis aries
403413 Canis lupus familiaris
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