Deoxyribonuclease I-Like 3 Proteins (DNASE1L3)

DNASE1L3 encodes a member of the deoxyribonuclease I family. Additionally we are shipping DNASE1L3 Antibodies (47) and DNASE1L3 Kits (13) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DNASE1L3 13421 O55070
DNASE1L3 116687 O89107
DNASE1L3 1776 Q13609
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Top DNASE1L3 Proteins at

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days

DNASE1L3 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus)

Human ,

More Proteins for Deoxyribonuclease I-Like 3 (DNASE1L3) Interaction Partners

Xenopus laevis Deoxyribonuclease I-Like 3 (DNASE1L3) interaction partners

  1. Cloning and apoptotic DNase (show DNASE2 Proteins) activity of Xenopus laevis DNase gamma

Mouse (Murine) Deoxyribonuclease I-Like 3 (DNASE1L3) interaction partners

  1. Study reports that DNASE1L3-deficient mice rapidly develop autoantibodies to DNA and chromatin, followed by an systemic lupus erythematosus-like disease. Circulating DNASE1L3 is produced by dendritic cells and macrophages, and its levels inversely correlate with anti-DNA antibody response.

  2. DNase gamma, but not CAD, is the effector endonuclease for INDF in cells undergoing necrosis.

  3. A comparison of the expression and transport of DNAse1 (show DNASE1 Proteins) from rats and DNAse1L3 from mice is reported.

  4. These results suggest that DNasegamma provides an alternative mechanism for inducing nuclear changes when the working apoptotic cascade is unsuitable for caspase-activated DNase (show DFFB Proteins) activation.

  5. serum contains two nucleases, DNase1 (show DNASE1 Proteins) and DNase1l3, which may substitute or cooperate with each other during DNA degradation, providing effective clearance after exposure or release from dying cells.

Human Deoxyribonuclease I-Like 3 (DNASE1L3) interaction partners

  1. Single nucleotide polymorphisms producing a loss-of-function variant of the enzymes in DNASE1 (show DNASE1 Proteins), DNASE1L3, and DNASE2 (show DNASE2 Proteins), possibly serving as a genetic risk factor for autoimmune diseases, were confirmed.

  2. Data indicate a likely functional variant influencing scleroderma susceptibility at deoxyribonuclease I-like 3 protein DNASE1L3 missense polymorphism rs35677470.

  3. Single nucleotide polymorphisms in the DNASE1L3 is associated with autoimmune diseases.

  4. DNASE1L3 mutations occur in hypocomplementemic urticarial vasculitis syndrome.

  5. These results suggest a cooperative activity between CAD and DNAS1L3 to accomplish internucleosomal DNA fragmentation .

  6. We identified a rare autosomal recessive form of systemic lupus erythematosus, in which autozygome analysis revealed a null mutation in the DNASE1L3 gene

  7. investigates the distribution of DNASE1L3 gene SNPs in exons of the gene in eight Asian, three African, and three Caucasian populations worldwide using newly devised genotyping methods.

  8. The Poly(ADP-ribose) polymerase-1 (show PARP1 Proteins)-regulated endonuclease DNAS1L3 is required for etoposide-induced internucleosomal DNA fragmentation and increases etoposide cytotoxicity in transfected osteosarcoma cells.

  9. Identification of two functional nuclear localization signals in DNase gamma that have a role in apoptotic DNA fragmentation.

  10. DNase gamma is involved in the generation of resected double-strand DNA breaks associated with somatic hypermutation

DNASE1L3 Protein Profile

Protein Summary

This gene encodes a member of the deoxyribonuclease I family. The encoded protein hydrolyzes DNA, is not inhibited by actin, and mediates the breakdown of DNA during apoptosis. Mutations in this gene are a cause of systemic lupus erythematosus-16. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with DNASE1L3

  • deoxyribonuclease I-like 3 (dnase1l3)
  • deoxyribonuclease I-like 3 (DNASE1L3)
  • zgc:101000 (zgc:101000)
  • deoxyribonuclease I-like 3 (LOC100225960)
  • deoxyribonuclease 1-like 3 (Dnase1l3)
  • lymphocyte stimulating determinant (Lsd)
  • cb217 protein
  • DHP2 protein
  • DNAS1L3 protein
  • dnase1l3 protein
  • DNasegamma protein
  • drng-a protein
  • LSD protein
  • MGC64241 protein
  • MGC76250 protein
  • MGC89816 protein
  • SLEB16 protein
  • wu:fb44e02 protein
  • zgc:66031 protein

Protein level used designations for DNASE1L3

deoxyribonuclease I-like 3 , deoxyribonuclease gamma , deoxyribonuclease 1-like 3 , DNase-gamma , DNase I homolog protein DHP2 , DNase I-like 3 , DNase gamma , LS-DNase , liver and spleen DNase , macrophage specific DNase I , DNaseY , DNase I homolog protein 2 , Liver and spleen DNase , deoxyribonuclease I-like III

379439 Xenopus laevis
394515 Xenopus (Silurana) tropicalis
416008 Gallus gallus
445317 Danio rerio
460477 Pan troglodytes
476576 Canis lupus familiaris
512512 Bos taurus
702613 Macaca mulatta
792196 Danio rerio
100225960 Taeniopygia guttata
13421 Mus musculus
116687 Rattus norvegicus
1776 Homo sapiens
110311 Mus musculus
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