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DMKN is upregulated in inflammatory diseases, and it was first observed as expressed in the differentiated layers of skin. Additionally we are shipping Dermokine Kits (7) and Dermokine Proteins (4) and many more products for this protein.
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These results suggest that dermokine-beta delays early cutaneous wound healing in part by inhibiting expression of CXC chemokines containing the ERL-sequence motif.
Dermokine-beta impairs ERK (show EPHB2 Antibodies) signaling through direct binding to GRP78 (show HSPA5 Antibodies)
Dmkndelta activates Rab5 (show RAB5A Antibodies) function and thus is involved in the early endosomal trafficking.
Analysis of alternative spliced transcripts produced from the dermokine gene.
Dermokine gene is expressed in epithelial tissues other than the skin and this expression is transcriptionally and posttranscriptionally complex.
Authors improved the knowledge of Dmkn expression in mouse and highlighted a role for Dmkn beta and gamma in cornification.
identification of a novel gene (dermokine)giving rise to two splicing variants, both of which are expressed in the spinous layer of epidermis
Drmkn and Krtdap are the highest differentially expressed genes in epidermis embryonic development in mice.
This gene is upregulated in inflammatory diseases, and it was first observed as expressed in the differentiated layers of skin. The most interesting aspect of this gene is the differential use of promoters and terminators to generate isoforms with unique cellular distributions and domain components. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
, epidermis-specific secreted protein SK30/SK89