Desmin Proteins (DES)

DES encodes a muscle-specific class III intermediate filament. Additionally we are shipping Desmin Antibodies (410) and Desmin Kits (59) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DES 1674 P17661
DES 64362 P48675
DES 13346 P31001
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Top Desmin Proteins at antibodies-online.com

Showing 10 out of 27 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 60 to 71 Days
$3,287.17
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 4 Days
$522.50
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$666.00
Details
HOST_Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Log in to see 10 to 12 Days
$229.85
Details
HOST_Escherichia coli (E. coli) Human His tag   10 μg Log in to see 15 to 16 Days
$300.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
Yeast Chicken His tag   1 mg Log in to see 60 to 71 Days
$3,303.67
Details
Yeast Dog His tag   1 mg Log in to see 60 to 71 Days
$3,322.00
Details

DES Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
, ,
Rat (Rattus)

Mouse (Murine)

More Proteins for Desmin (DES) Interaction Partners

Zebrafish Desmin (DES) interaction partners

  1. Desmin intermediate filaments are required for normal active force generation.

  2. Desmin distribution during muscle maturation changes from dispersed aggregates to a perinuclear concentration to striated (show NSDHL Proteins) afterwards.

Human Desmin (DES) interaction partners

  1. demonstrate that the expression of mutant desmin causes disruption of the extrasarcomeric desmin cytoskeleton and extensive mitochondrial abnormalities regarding subcellular distribution, number and shape

  2. Mutation in the Core Structure of Desmin Intermediate Filaments Affects Myoblast Elasticity

  3. Data show that the filament elongation of both desmin and keratin K8/K18 (show KRT18 Proteins) proceeds very similar to that of vimentin (show VIM Proteins).

  4. Cdk1 (show CDK1 Proteins)-induced desmin phosphorylation is required for efficient separation of desmin-IFs and generally detected in muscular mitotic cells in vivo.

  5. Desmin, Lamin A/C, MMP9, and histone H4 were upregulated in the placental villi of women experiencing early pregnancy loss.

  6. Increasing desmin abnormalities were correlated with diastolic dysfunction progression.

  7. expression level of mutant versus wild-type desmin in mouse model as well as in skeletal muscle specimens derived from human R350P desminopathies; findings demonstrate missense-mutant desmin inflicts changes of the subcellular localization and turnover of desmin itself and of direct desmin-binding partners

  8. Results propose that the mutations affect desmin structure and cause its aberrant folding and subsequent aggregation, triggering disruption of myofibrils organization.

  9. identified disruption of the desmin system in gastrocnemius myofibers as an index of the myopathy and limitation of muscle function in patients with peripheral artery disease.

  10. The desmin intermediate filament network plays a major role in striated (show NSDHL Proteins) muscle development and maintenance by integrating and coordinating most cellular components necessary for proper mechanochemical signaling, organelle cross-talk, energy production and trafficking processes required for proper tissue homeostasis. [Review]

Mouse (Murine) Desmin (DES) interaction partners

  1. demonstrate that the expression of mutant desmin causes disruption of the extrasarcomeric desmin cytoskeleton and extensive mitochondrial abnormalities regarding subcellular distribution, number and shape

  2. The disease-mutant desmin variants E245D and T453I exhibited increased binding affinity for nebulette (show NEBL Proteins), delayed filament assembly kinetics, and caused significant weakening of networks.

  3. desmin and alphaBeta-crystallin are localized at sarcoplasmic reticulum (SR)-mitochondria-associated membranes (MAMs), where they interact with VDAC, Mic60 - the core component of mitochondrial contact site and cristae organizing system (MICOS) complex - and ATP synthase, suggesting that these associations could be crucial in mitoprotection at different levels.

  4. Complete lack or markedly decreased expression of mutant R349P desmin impairs the structural and functional integrity of neuromuscular endplates.

  5. Cdk1 (show CDK1 Proteins)-induced desmin phosphorylation is required for efficient separation of desmin-IFs and generally detected in muscular mitotic cells in vivo.

  6. the coordinated up-regulations of desmin and alpha- actinin (show ACTN1 Proteins) specifically in the early stage of diastolic heart failure mouse models indicate a novel myocardial response.

  7. E413K mutation induces desmin network disorganization, desmin aggregate formation and alters the traction forces generation of single myoblasts.

  8. This study identifies desmin as a new Asb2b target for proteasomal degradation in cardiomyocytes and suggests that accumulation of desmin could contribute to UPS impairment in Hypertrophic cardiomyopathy mice and patients

  9. found that inhibition of the Rac1 pathway (a G protein signaling pathway involved in diverse cellular processes), antioxidant treatment, and stimulation of macroautophagy reduced desmin aggregation by up to 75% in this model

  10. This demonstration of biomechanical integration by the desmin intermediate filament system suggests that it plays an active biological role in muscle in addition to its accepted structural role

Cow (Bovine) Desmin (DES) interaction partners

  1. Results show that expression of desmin increased during the late fattening stage of of hanwoo steers and it contributes to the muscle contractile apparatus.

Desmin (DES) Protein Profile

Protein Summary

This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies.

Gene names and symbols associated with Desmin Proteins (DES)

  • desmin-like (LOC100059397)
  • desmin (DES)
  • desmin (des-b)
  • desmin, gene 1 (des.1)
  • desmin (des)
  • desmin (LOC100220724)
  • desmin-like (LOC100402007)
  • desmin a (desma)
  • desmin (Des)
  • desmin b (desmb)
  • desmin, gene 1 (des.1-a)
  • desmin, gene 2 (des.2)
  • cb290 protein
  • cmd1i protein
  • CSM1 protein
  • CSM2 protein
  • des protein
  • des-a protein
  • des-b protein
  • desm protein
  • desmin protein
  • fb59a12 protein
  • LGMD2R protein
  • LOC100220724 protein
  • MGC52614 protein
  • MGC75911 protein
  • MGC80853 protein
  • wu:fb59a12 protein
  • wu:fc11d08 protein
  • zgc:109859 protein
  • zgc:154009 protein

Protein level used designations for Desmin Proteins (DES)

desmin , desmin, gene 1 , desmin-like , intermediate filament protein , muscle-specific intermediate filament desmin , fc11d08

GENE ID SPECIES
100059397 Equus caballus
100137488 Papio anubis
446868 Xenopus laevis
394739 Xenopus (Silurana) tropicalis
470657 Pan troglodytes
100136041 Oncorhynchus mykiss
100220724 Taeniopygia guttata
100402007 Callithrix jacchus
30148 Danio rerio
100586972 Nomascus leucogenys
395906 Gallus gallus
1674 Homo sapiens
64362 Rattus norvegicus
497091 Canis lupus familiaris
13346 Mus musculus
101097010 Felis catus
280765 Bos taurus
101117308 Ovis aries
100328890 Oryctolagus cuniculus
396725 Sus scrofa
100733478 Cavia porcellus
101837949 Mesocricetus auratus
768287 Danio rerio
379869 Xenopus laevis
733312 Xenopus laevis
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