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Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Additionally we are shipping Desmoglein 2 Kits (8) and Desmoglein 2 Proteins (6) and many more products for this protein.
Showing 10 out of 169 products:
Cow (Bovine) Monoclonal Desmoglein 2 Primary Antibody for IHC (fro), IF - ABIN111817
Yang, Shaio, Wang, Wu, Stone: Neuroblastoma cell-mediated leukocyte chemotaxis: lineage-specific differentiation of interleukin-8 expression. in Experimental cell research 1994
Show all 9 references for ABIN111817
Human Monoclonal Desmoglein 2 Primary Antibody for FACS, IF - ABIN1106982
Wahl: Generation of monoclonal antibodies specific for desmoglein family members. in Hybridoma and hybridomics 2002
Show all 8 references for ABIN1106982
Human Monoclonal Desmoglein 2 Primary Antibody for EIA, IHC (fro) - ABIN112136
Franke, Nuber, Schmidt, Schäfer: Desmosomes--dual junctional principles of intra- and supracellular order in epithelial differentiation and tissue formation. in Verhandlungen der Deutschen Gesellschaft für Pathologie 1995
Show all 6 references for ABIN112136
Human Monoclonal Desmoglein 2 Primary Antibody for EIA, IHC (fro) - ABIN112242
Demlehner, Schäfer, Grund, Franke: Continual assembly of half-desmosomal structures in the absence of cell contacts and their frustrated endocytosis: a coordinated Sisyphus cycle. in The Journal of cell biology 1995
Show all 3 references for ABIN112242
Human Polyclonal Desmoglein 2 Primary Antibody for EIA, WB - ABIN360106
Posch, Posch, Geier, Erdmann, Mueller, Richter, Ruppert, Pankuweit, Maisch, Perrot, Buttgereit, Dietz, Haverkamp, Ozcelik: A missense variant in desmoglein-2 predisposes to dilated cardiomyopathy. in Molecular genetics and metabolism 2008
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Human Polyclonal Desmoglein 2 Primary Antibody for IHC, WB - ABIN2782147
Cirillo, Lanza, De Rosa, Cammarota, La Gatta, Gombos, Lanza: The most widespread desmosomal cadherin, desmoglein 2, is a novel target of caspase 3-mediated apoptotic machinery. in Journal of cellular biochemistry 2008
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Human Monoclonal Desmoglein 2 Primary Antibody for ICC, IF - ABIN1742581
Keim, Johnson, Wheelock, Wahl: Generation and characterization of monoclonal antibodies against the proregion of human desmoglein-2. in Hybridoma (2005) 2008
Both Dsg2 mRNA and protein were highly expressed in non-small cell lung cancer (NSCLC) tissues and associated with NSCLC size, but not with overall survival of patients.
a novel pathway of CSTA (show CSTA Antibodies) regulation involving Dsg2
DSG2 and DSG3 (show DSG3 Antibodies) might be potential diagnostic markers for squamous cell carcinoma of the lung.
In endometrial luminal epithelium, cadherin 6 (show CDH6 Antibodies), desmoglein 2 and plexin b2 (show PLXNB2 Antibodies) were surprisingly found in the apical as well as the lateral membrane domain; their knock-down compromised epithelial integrity.
a low DSG2 expression phenotype is a useful prognostic biomarker of tumor aggressiveness and may serve as an aid in identifying patients with clinically significant prostate cancer.
Six variants of uncertain clinical significance in the PKP2 (show PKP2 Antibodies), JUP (show JUP Antibodies), and DSG2 genes showed a deleterious effect on mRNA splicing, indicating these are ARVD (show TGFB3 Antibodies)/C-related pathogenic splice site mutations.
This structure reveals that the ectodomain of Dsg2 is flexible even in the calcium-bound state and, on average, is shorter than the type 1 cadherin crystal structures.
Data demonstrate that partner desmosomal cadherins Dsg2 and Dsc2 (show DSC2 Antibodies) play opposing roles in controlling colonic carcinoma cell proliferation through differential effects on EGFR (show EGFR Antibodies) signaling.
Desmoglein 2 expression attenuates migration of melanoma cells, mediated by downregulation of secretogranin II (show SCG2 Antibodies).
Reduced cardiac desmoglein-2 and desmocollin-2 (show DSC2 Antibodies) levels appear to be specifically associated with Arrhythmogenic right ventricular Dysplasia/cardiomyopathy, independent of underlying mutations.
Data suggest that loss of desmoglein 2 (Dsg2) compromises adhesion, and that this is a major pathogenic mechanism in DSG2-related and probably other desmosome-related arrhythmogenic cardiomyopathy (AC).
Dsg2 modulates Gli1 (show GLI1 Antibodies) expression. Dsg2-mediated hyperproliferation, MEK (show MDK Antibodies)/Erk1/2 (show MAPK1/3 Antibodies) activation, and accelerated squamous tumor development are enhanced on the Ptc1 (show PTCH1 Antibodies)+/lacZ (show GLB1 Antibodies) background.
Data demonstrate that desmoglein-2 plays a critical role in cardiomyocyte cohesion and function.
Dsg2 compensates for Dsg3 (show DSG3 Antibodies) depletion with regard to cell cohesion, but does not regulate p38 MAPK (show MAPK14 Antibodies) signaling.
In vivo interaction between Dsg2 and Na(V)1.5 provides a molecular pathway for the observed electrical disturbances during the early arrhythmogenic right ventricular cardiomyopathy.
Mutant desmoglein 2 cannot support the increased requirements placed on intercalated disc adhesion during postnatal heart development. This induces cardiomyocyte death, aseptic inflammation and fibrotic replacement.
ventricular arrhythmias that has been linked to mutations in desmosomal proteins including desmoglein 2
Myocyte necrosis underlies progressive myocardial dystrophy in N271S-dsg2-related arrhythmogenic right ventricular cardiomyopathy.
Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. This gene product is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This second family member is expressed in colon, colon carcinoma, and other simple and stratified epithelial-derived cell lines. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10.
, Dsg alpha
, desmocollin a
, cadherin family member 5