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DSG4 encodes a member of the desmoglein subgroup of desmosomal cadherins. Additionally we are shipping Desmoglein 4 Proteins (8) and Desmoglein 4 Kits (3) and many more products for this protein.
Showing 10 out of 29 products:
Human Polyclonal Desmoglein 4 Primary Antibody for IHC - ABIN966012
Kljuic, Bazzi, Sundberg, Martinez-Mir, OShaughnessy, Mahoney, Levy, Montagutelli, Ahmad, Aita, Gordon, Uitto, Whiting, Ott, Fischer, Gilliam, Jahoda, Morris, Panteleyev, Nguyen, Christiano: Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and acquired pemphigus vulgaris. in Cell 2003
Show all 5 references for ABIN966012
Human Polyclonal Desmoglein 4 Primary Antibody for IHC (fro) - ABIN401676
Bazzi, Getz, Mahoney, Ishida-Yamamoto, Langbein, Wahl, Christiano: Desmoglein 4 is expressed in highly differentiated keratinocytes and trichocytes in human epidermis and hair follicle. in Differentiation; research in biological diversity 2006
This study further extends the body of evidence that mutations in the DSG4 gene result in both hypotrichosis and monilethrix-like scalp hair.
Epitopes of Dsg4 may play a role in the pathogenesis of pemphigus vulgaris (show DSG3 Antibodies) .
show that HOXC13, LEF1 (show LEF1 Antibodies) and FOXN1 (show FOXN1 Antibodies) repress DSG4 transcription and provide in vitro and in vivo evidence correlating the Notch (show NOTCH1 Antibodies) pathway with the activation and/or maintenance of DSG4 expression in the hair follicle.
the human desmoglein 4 gene (DSG4) demonstrates that it is composed of 16 exons spanning approximately 37 kb of 18q12 and is situated between DSG1 (show DSG1 Antibodies) and DSG3 (show DSG3 Antibodies).
The essential role of desmoglein 4 in skin was established by identifying mutations in families with inherited hypotrichosis, as well as in the lanceolate hair mouse. We also show that DSG4 is an autoantigen in pemphigus vulgaris (show DSG3 Antibodies).
DSG4 is pathogenic in pemphigus and staphylococcal scalded skin syndrome.
The DSG4 protein is expressed in the more highly differentiated layers of the epidermis.
identification of a single nucleotide deletion within exon 3 of DSG4, designated 87delG in a Pakistani family with localized autosomal recessive hypotrichosis; this results in a frameshift and premature termination codon 162 bp downstream of the deletion
show that HOXC13, LEF1 (show LEF1 Antibodies) and FOXN1 (show FOXN2 Antibodies) repress DSG4 transcription and provide in vitro and in vivo evidence correlating the Notch (show NOTCH1 Antibodies) pathway with the activation and/or maintenance of DSG4 expression in the hair follicle.
Mast cell hyperplasia is associated with Dsg4-deficient hypotrichosis mice.
Smad4 (show SMAD4 Antibodies) loss-associated Dsg4 depletion contributed, at least in part, to hair follicles degeneration in Smad4 (show SMAD4 Antibodies) deficient skin.
This gene encodes a member of the desmoglein subgroup of desmosomal cadherins. The encoded protein is a transmembrane component in desmosomes and may play a role in cell-cell adhesion in epithelial cells. Mutations in the gene are associated with localized autosomal recessive hypotrichosis and potentially in other skin disorders. Alternate splicing results in multiple transcript variants.
, CDH family member 13
, cadherin family member 13
, lanceolate hair