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Destrin (Actin Depolymerizing Factor) Proteins (DSTN)

The product of DSTN belongs to the actin-binding proteins ADF family. Additionally we are shipping Destrin Antibodies (72) and Destrin Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat DSTN DSTN 296197  
DSTN 56431 Q9R0P5
DSTN 11034 P60981
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Top Destrin Proteins at

Showing 9 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

DSTN Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,

Top referenced Destrin Proteins

  1. Human Destrin Protein expressed in Escherichia coli (E. coli) - ABIN1098314 : Kanamori, Hayakawa, Suzuki, Titani: Identification of two 17-kDa rat parotid gland phosphoproteins, subjects for dephosphorylation upon beta-adrenergic stimulation, as destrin- and cofilin-like proteins. in The Journal of biological chemistry 1995 (PubMed)
    Show all 2 references for ABIN1098314

More Proteins for Destrin (Actin Depolymerizing Factor) (DSTN) Interaction Partners

Mouse (Murine) Destrin (Actin Depolymerizing Factor) (DSTN) interaction partners

  1. Actin depolymerizing factor/cofilin (show CFL1 Proteins) double mutant mice exhibited hyperlocomotion, impulsivity, and impaired working memory. Hyperlocomotion and impulsive behavior were reversed by methylphenidate.

  2. SRF binding is significantly decreased in the destrin (corn1) mutant cornea.

  3. A single QTL is responsible for modification of neovascularization in the Dstn null mutation mouse.

  4. findings identify actin-depolymerizing factor (ADF) as a key signaling molecule in the regulation of BBB integrity and suggest that ADF (show TXN Proteins) might be used as a target to modulate diseases accompanied by ox-LDL-induced BBB compromise.

  5. n-cofilin can compensate for the loss of ADF in excitatory synapses. ADF and n-cofilin cooperate in controlling synaptic actin content

  6. Results indicate that ADF (show TXN Proteins) activity, provided by either cofilin1 or destrin, is essential in UB epithelial cells for normal growth and branching.

  7. Findings show that ADF (show TXN Proteins)/n-cofilin (show CFL1 Proteins)-null MKs (show MKKS Proteins) develop significantly fewer proplatelets.

  8. Developmentally regulated actin filament depolymerizing factor expression in the cochlea suggests a temporally restricted function in the stereocilia and a hitherto undescribed role of ADF (show TXN Proteins).

  9. Destrin deletion has differential effects on spontaneous hem- and lymphangiogenesis in the normally avascular cornea.

  10. Dstn mutations and resultant actin dynamics abnormalities have a strong impact on the gene expression profile in vivo.

Human Destrin (Actin Depolymerizing Factor) (DSTN) interaction partners

  1. analysis of human Cof1, Cof2, and ADF effects on actin filament severing and turnover

  2. Destrin is upregulated in nerve-invasive pancreatic cancer cells and its expression might be related to perineural invasiveness

  3. The ADF (show GSN Proteins)/cofilin1-dependent severing of actin filaments exposes and promotes the activation of SPCA1 (show ATP2C1 Proteins), which pumps Ca(2 (show CA2 Proteins)+) into the lumen of the TGN (show TG Proteins) for the sorting of the class of secretory cargo that binds Ca(2 (show CA2 Proteins)+).

  4. Changes in the expression of cytoskeletal regulatory proteins such as LIMK (show LIMK1 Proteins) and cofilin (show CFL1 Proteins) may play a role in weakening thoracic aortic medial tissue, as a precondition to thoracic aortic dissection.

  5. The results of this study suggested that temporally regulated ADF/cofilin (show CFL1 Proteins) activities function in postsynaptic modifications of receptor number and spine size during synaptic plasticity.

  6. differences in actin binding by human ADF (show GSN Proteins) and cofilin (show CFL1 Proteins)

  7. Important sequence differences between actin-depolymerizing factor/cofilin (show CFL1 Proteins) were correlated with unique structural determinants in the F-actin-binding site to account for differences in biochemical activities of the two proteins.

  8. In the absence of any crystal structures of ADF or cofilin in complex with actin, these studies provide further information about the binding sites on F-actin for these important actin regulatory proteins.

  9. destrin is a significant regulator of various processes important for invasive phenotype of human colon cancer Isreco1 cells whereas cofilin-1 (show CFL1 Proteins) may be involved in only a subset of them

Destrin (DSTN) Protein Profile

Protein Summary

The product of this gene belongs to the actin-binding proteins ADF family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin). Two transcript variants encoding distinct isoforms have been identified for this gene.

Gene names and symbols associated with DSTN

  • destrin-like 1 (Dstnl1)
  • destrin (actin depolymerizing factor) (DSTN)
  • destrin (DSTN)
  • destrin (actin depolymerizing factor) (dstn)
  • destrin-like (LOC100190417)
  • destrin (LOC100341305)
  • destrin (LOC100358081)
  • destrin (Dstn)
  • 2610043P17Rik protein
  • ACTDP protein
  • ADF protein
  • AU042046 protein
  • bA462D18.2 protein
  • corn1 protein
  • destrin protein
  • Dsn protein
  • DSTN protein
  • LOC100190417 protein
  • sid23p protein

Protein level used designations for DSTN

destrin , destrin (actin depolymerizing factor) , putative destrin , actin-depolymerizing factor , corneal disease 1 , sid 23 , ADF , bA462D18.2 (destrin (actin depolymerizing factor ADF) (ACTDP)) , actin depolymerizing factor

296197 Rattus norvegicus
458108 Pan troglodytes
695969 Macaca mulatta
100038216 Xenopus (Silurana) tropicalis
100190417 Taeniopygia guttata
100341305 Oryctolagus cuniculus
100358081 Oryctolagus cuniculus
56431 Mus musculus
502674 Rattus norvegicus
11034 Homo sapiens
379282 Xenopus laevis
396539 Gallus gallus
477147 Canis lupus familiaris
445516 Sus scrofa
513267 Bos taurus
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