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Developmental Pluripotency Associated 3 Proteins (DPPA3)

DPPA3 encodes a protein that in mice may function as a maternal factor during the preimplantation stage of development. Additionally we are shipping DPPA3 Antibodies (20) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DPPA3 359787 Q6W0C5
DPPA3 73708 Q8QZY3
DPPA3 297576 Q6IMK0
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Top DPPA3 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$407.00
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,355.83
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$498.21
Details

DPPA3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human

Mouse (Murine)

Rat (Rattus)

Top referenced DPPA3 Proteins

  1. Human DPPA3 Protein expressed in Escherichia coli (E. coli) - ABIN1098689 : Nakamura, Arai, Umehara, Masuhara, Kimura, Taniguchi, Sekimoto, Ikawa, Yoneda, Okabe, Tanaka, Shiota, Nakano: PGC7/Stella protects against DNA demethylation in early embryogenesis. in Nature cell biology 2007 (PubMed)

More Proteins for Developmental Pluripotency Associated 3 (DPPA3) Interaction Partners

Cow (Bovine) Developmental Pluripotency Associated 3 (DPPA3) interaction partners

  1. DPPA3 is a maternal factor (show ZAR1 Proteins) important for correct epigenetic remodeling and normal embryonic development in cattle, indicating that the role of DPPA3 during early development is conserved between species.

Human Developmental Pluripotency Associated 3 (DPPA3) interaction partners

  1. Data suggest enforced expression of Stella into normal cells induces not only global DNA demethylation but also neoplastic transformation and increases metastatic ability; these changes involve altered regulation of neoplastic gene expression.

  2. Considering that impaired DNA methylation (show HELLS Proteins) profiles are associated with various developmental or disease phenomena, Stella may be a powerful tool with which to study the biological effects of global DNA hypomethylation

  3. a role for STELLA in facilitating germline and endodermal differentiation of human ES cells

  4. human adult tissue-specific transcripts originate via retrotransposition of the pluripotent cell-specific gene, Dppa3

  5. These results demonstrate that PGC7/Stella is indispensable for the maintenance of methylation involved in epigenetic reprogramming after fertilization.

  6. In mice, a targeted mutation results in reduced female fertility and (show MTA2 Proteins)may function as a mammalian maternal effect gene.

  7. In mice, knockout experiments show this gene may be a maternal factor (show ZAR1 Proteins) in cleavage stage embryogenesis.

Mouse (Murine) Developmental Pluripotency Associated 3 (DPPA3) interaction partners

  1. In-depth transcriptome analysis of this mESC state reveals Dppa3 as a direct downstream target of Tbx3 (show TBX3 Proteins).We show that Tbx3 (show TBX3 Proteins), a downstream target of Wnt (show WNT2 Proteins) signaling, fine tunes these divergent roles of Wnt (show WNT2 Proteins) signaling in mESCs

  2. Dppa3 has a critical role in generation of fully reprogrammed iPS (show SLC27A4 Proteins) cells and maintenance of Dlk1 (show DLK1 Proteins)-Dio3 (show DIO3 Proteins) imprinting

  3. Stella protects maternal chromosomes from aberrant epigenetic modifications to ensure early embryogenesis.

  4. Chromocenter formation is impaired in Stella-null embryos.

  5. we propose that Dppa3 is involved in the Tet-mediated active demethylation process during reprogramming of primordial germ cells.

  6. PGC7 protects 5mC from Tet3-mediated conversion to 5hmC by binding to maternal chromatin containing dimethylated histone H3 (show HIST3H3 Proteins) lysine 9 (H3K9me2) in mice

  7. These Dppa3-MCM strains offer valuable opportunities to explore gene function in both loss-of-function and gain-of-function experiments at a variety of time points during germ cell development.

  8. DPPA3 is an essential factor for the production of functional oocytes through transcriptional repression and chromatin condensation.

  9. Data show that STELLA was found in both the nucleus and cytoplasm in a variety of cell types, both within and outside of the putative primordial germ cells (PGCs)trajectory.

  10. Data show that Stella is specifically expressed in preimplantation embryos and in the germline.

DPPA3 Protein Profile

Protein Summary

This gene encodes a protein that in mice may function as a maternal factor during the preimplantation stage of development. In mice, this gene may play a role in transcriptional repression, cell division, and maintenance of cell pluripotentiality. In humans, related intronless loci are located on chromosomes 14 and X.

Gene names and symbols associated with DPPA3

  • developmental pluripotency associated 3 (DPPA3)
  • developmental pluripotency-associated 3 (Dppa3)
  • 2410075G02Rik protein
  • PCG7 protein
  • PGC7 protein
  • Stella protein

Protein level used designations for DPPA3

developmental pluripotency-associated protein 3 , stella , stella-related protein , developmental pluripotency associated 3 , compaction-associated protein 1 , primordial germ cell 7 , primordial germ cell protein 7

GENE ID SPECIES
616433 Bos taurus
748273 Pan troglodytes
359787 Homo sapiens
73708 Mus musculus
297576 Rattus norvegicus
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