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The protein encoded by DGKQ contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. Additionally we are shipping Diacylglycerol Kinase, theta 110kDa Antibodies (62) and and many more products for this protein.
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Diacylglycerol kinase theta is regulated by magnesium and zinc.
The SF1 (show NR5A1 ELISA Kits) and SREBP1 (show SREBF1 ELISA Kits) activate DGKtheta; transcription in a cAMP-dependent manner in human adrenocortical cells.
This study found that the minor alleles of GAK rs1564282 and DGKQ rs11248060 significantly increase the risk of PD in Han Chinese populations.
Data suggest that diacylglycerol kinase theta is a key mediator of bile-acid-stimulated modulation of farnesoid X receptor/mTOR (show FRAP1 ELISA Kits) complex 2/Akt (show AKT1 ELISA Kits) signaling pathway and glucose metabolism/homoeostasis in hepatocytes.
DGKtheta; translocation and activity is regulated by the concerted activity of EGFR and PKC.
DGK-theta; directly interacts with, and is activated by, basic proteins such as histone H1 (show H1F0 ELISA Kits) and Tau with nm affinity, consistent with a potential role for a polybasic protein or protein domain in the activation of this enzyme.
Nuclear DGK-theta co-localizes with phosphatidylinositol 4,5-bisphosphate (PIP(2)) in domains that correspond to nuclear speckles.
DGK (show DGKB ELISA Kits) interacts selectively with and is phosphorylated by PKCepsilon (show PRKCE ELISA Kits) and -eta and peptide agonist-induced selective activation of PKCepsilon (show PRKCE ELISA Kits) directly leads to DGK (show DGKB ELISA Kits) translocation
Data show that cyclic AMP (show APRT ELISA Kits)-stimulated interaction between steroidogenic factor 1 (show NR5A1 ELISA Kits) and diacylglycerol kinase theta facilitates induction of CYP17 (show CYP17A1 ELISA Kits).
The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction.
diacylglycerol kinase, theta 110kDa
, diacylglycerol kinase theta
, DAG kinase theta
, diacylglycerol kinase, delta (110 kDa)
, diglyceride kinase theta