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Diacylglycerol O-Acyltransferase 2 Proteins (DGAT2)

DGAT2 encodes one of two enzymes which catalyzes the final reaction in the synthesis of triglycerides in which diacylglycerol is covalently bound to long chain fatty acyl-CoAs. Additionally we are shipping DGAT2 Antibodies (65) and DGAT2 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DGAT2 84649 Q96PD7
DGAT2 67800 Q9DCV3
Rat DGAT2 DGAT2 252900 Q5FVP8
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Top DGAT2 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

DGAT2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
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More Proteins for Diacylglycerol O-Acyltransferase 2 (DGAT2) Interaction Partners

Human Diacylglycerol O-Acyltransferase 2 (DGAT2) interaction partners

  1. uPA (show PRAP1 Proteins)/uPAR (show PLAUR Proteins) stimulates triglyceride synthesis in Huh7 hepatoma cells via p38 (show CRK Proteins)-dependent upregulation of DGAT2

  2. DGAT2 is regulated by gp78 (show AMFR Proteins)-associated endoplasmic-reticulum-associated degradation at the post-translational level.

  3. Hepatic triacylglycerol synthesis and secretion: DGAT2 as the link between glycaemia and triglyceridaemia.

  4. describe distinct but synergistic roles of the two DGATs in an integrated pathway of TAG synthesis and secretion, with DGAT2 acting upstream of DGAT1 (show DGAT1 Proteins)

  5. Niacin treatment may reduce liver fat content in Chinese patients with dyslipidemia and the mechanism may involve inhibition of DGAT2.

  6. DGAT2 expression is decreased in psoriatic skin.

  7. Niacin selectively inhibited DGAT2 but not DGAT1 (show DGAT1 Proteins) activity, but had no effect on the expression of DGAT1 (show DGAT1 Proteins) and DGAT2 mRNA

  8. our results do not support the hypothesis of an important role of common genetic variation in DGAT2 for the development of obesity

  9. diacylglycerol acyltransferase 2 (show AWAT1 Proteins) expression is regulated by CAAT/enhancer-binding protein beta (C/EBPbeta (show CEBPB Proteins)) and C/EBPalpha (show CEBPA Proteins) during adipogenesis

  10. Overexpression of human DGAT2 in glycolytic muscle of mice promotes insulin (show INS Proteins) resistance in this tissue and may contribute to the development of diabetes.

Mouse (Murine) Diacylglycerol O-Acyltransferase 2 (DGAT2) interaction partners

  1. when intestinal DGAT2 is present in excess (show RCC1 Proteins), mRNA levels of genes involved in fatty acid oxidation were reduced. This result suggests that reduced fatty acid oxidation may contribute to increased TG secretion by overexpression of DGAT2 in intestine

  2. role of Mtp (show LAPTM4A Proteins) and DGAT2 in hepatic steatosis

  3. DGAT2 is capable of catalyzing TG synthesis and promote its storage in cytosolic lipid droplets independent of its localization in the ER.

  4. DAG-induced PKCepsilon (show PRKCE Proteins) activation plays a major role in nonalcoholic fatty liver disease (NAFLD)-associated hepatic insulin (show INS Proteins) resistance.

  5. Findings show that DGAT1 and DGAT2 account for the vast majority of TG synthesis in mice, and DGAT function is required for LDs in adipocytes, but not in all cell types.

  6. upregulation of DGAT2 plays an important role in the pathogenesis of alcoholic fatty liver disease

  7. the increased rate of hepatic TAG secretion and intracellular accumulation in ob/ob mice is accompanied by parallel increases in the activities of both DGAT I and DGAT II

  8. DGAT2 expression is increased in diabetic mice.

  9. leptin regulates adipocyte size by altering expression patterns of DGAT via central nervous system to determine the levels of triglyceride synthesis.

  10. DGAT1 (show DGAT1 Proteins) but not DGAT2 has a role in VLDL synthesis; increased plasma VLDL concentrations may promote obesity, whereas increased DGAT2 activity has a role in steatosis

Cow (Bovine) Diacylglycerol O-Acyltransferase 2 (DGAT2) interaction partners

  1. Data showed the associations between SNPs in intron 6 and intron 7 of the bovine diacylglycerolacyltransferase (show DGAT1 Proteins) (DGAT2) gene and growth traits in purebred Nanyang cattle.

  2. Study on the polymorphisms of DGAT2 gene in 92 Jiaxian red cattle show that genotype AB may have positive effect on body weight.

Arabidopsis thaliana Diacylglycerol O-Acyltransferase 2 (DGAT2) interaction partners

  1. expression of a codon-optimized version of the DGAT2 gene is able to restore neutral lipid accumulation in the Saccharomyces cerevisiae mutant strain

  2. Using immunogold technique, DGAT2 found in lipid bodies associated with microtubules; microtubules may participate in lipid biosynthesis as indicated by the presence of DGAT2. [DGAT2]

Pig (Porcine) Diacylglycerol O-Acyltransferase 2 (DGAT2) interaction partners

  1. These results suggest that the 13bp indel polymorphism in the 3'-UTR of porcine DGAT2 most likely affects fat deposition by altering its expression in pigs.

  2. The porcine CTNNBL1 (show CTNNBL1 Proteins) and DGAT2 genes affect porcine fat deposition and further investigation will be necessary to illustrate the underlying mechanisms.

DGAT2 Protein Profile

Protein Summary

This gene encodes one of two enzymes which catalyzes the final reaction in the synthesis of triglycerides in which diacylglycerol is covalently bound to long chain fatty acyl-CoAs. The encoded protein catalyzes this reaction at low concentrations of magnesium chloride while the other enzyme has high activity at high concentrations of magnesium chloride. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with DGAT2

  • diacylglycerol O-acyltransferase 2 (dgat2)
  • diacylglycerol O-acyltransferase 2 (DGAT2)
  • diacylglycerol O-acyltransferase 2 (Dgat2)
  • diacylglycerol O-acyltransferase 2 (AT3G51520)
  • diacylglycerol O-acyltransferase homolog 2 (mouse) (DGAT2)
  • 0610010B06Rik protein
  • ARAT protein
  • DDBDRAFT_0188804 protein
  • DDBDRAFT_0233097 protein
  • DDB_0188804 protein
  • DDB_0233097 protein
  • DGAT-2 protein
  • GS1999FULL protein
  • hmfn1045 protein
  • zgc:113394 protein

Protein level used designations for DGAT2

diacylglycerol O-acyltransferase homolog 2 , diglyceride acyltransferase 2 , acyl-CoA retinol O-fatty-acyltransferase , diacylglycerol O-acyltransferase-like protein 2 , retinol O-fatty-acyltransferase , diacylglycerol acyltransferase 2 , putative diacylglycerol O-acyltransferase , diacylglycerol acytransferase 2

GENE ID SPECIES
395003 Xenopus (Silurana) tropicalis
466714 Pan troglodytes
100442216 Pongo abelii
398800 Xenopus laevis
565316 Danio rerio
8627566 Dictyostelium discoideum AX4
84649 Homo sapiens
485185 Canis lupus familiaris
67800 Mus musculus
252900 Rattus norvegicus
404129 Bos taurus
824315 Arabidopsis thaliana
100294675 Sus scrofa
421309 Gallus gallus
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