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DGAT2 encodes one of two enzymes which catalyzes the final reaction in the synthesis of triglycerides in which diacylglycerol is covalently bound to long chain fatty acyl-CoAs. Additionally we are shipping DGAT2 Antibodies (84) and DGAT2 Kits (5) and many more products for this protein.
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Results identified a novel de novo p.Y223H mutation in the DGAT2 from an autosomal-dominant Korean Charcot-Marie-Tooth (CMT) family suggesting this mutation a novel underlying cause of an autosomal-dominant CMT2 phenotype.
uPA (show PRAP1 Proteins)/uPAR (show PLAUR Proteins) stimulates triglyceride synthesis in Huh7 hepatoma cells via p38 (show CRK Proteins)-dependent upregulation of DGAT2
DGAT2 is regulated by gp78 (show AMFR Proteins)-associated endoplasmic-reticulum-associated degradation at the post-translational level.
Hepatic triacylglycerol synthesis and secretion: DGAT2 as the link between glycaemia and triglyceridaemia.
describe distinct but synergistic roles of the two DGATs in an integrated pathway of TAG synthesis and secretion, with DGAT2 acting upstream of DGAT1 (show DGAT1 Proteins)
Niacin treatment may reduce liver fat content in Chinese patients with dyslipidemia and the mechanism may involve inhibition of DGAT2.
DGAT2 expression is decreased in psoriatic skin.
Niacin selectively inhibited DGAT2 but not DGAT1 (show DGAT1 Proteins) activity, but had no effect on the expression of DGAT1 (show DGAT1 Proteins) and DGAT2 mRNA
our results do not support the hypothesis of an important role of common genetic variation in DGAT2 for the development of obesity
diacylglycerol acyltransferase 2 (show AWAT1 Proteins) expression is regulated by CAAT/enhancer-binding protein beta (C/EBPbeta (show CEBPB Proteins)) and C/EBPalpha (show CEBPA Proteins) during adipogenesis
when intestinal DGAT2 is present in excess (show RCC1 Proteins), mRNA levels of genes involved in fatty acid oxidation were reduced. This result suggests that reduced fatty acid oxidation may contribute to increased TG secretion by overexpression of DGAT2 in intestine
role of Mtp (show LAPTM4A Proteins) and DGAT2 in hepatic steatosis
DGAT2 is capable of catalyzing TG synthesis and promote its storage in cytosolic lipid droplets independent of its localization in the ER.
DAG-induced PKCepsilon (show PRKCE Proteins) activation plays a major role in nonalcoholic fatty liver disease (NAFLD)-associated hepatic insulin (show INS Proteins) resistance.
Findings show that DGAT1 and DGAT2 account for the vast majority of TG synthesis in mice, and DGAT function is required for LDs in adipocytes, but not in all cell types.
upregulation of DGAT2 plays an important role in the pathogenesis of alcoholic fatty liver disease
the increased rate of hepatic TAG secretion and intracellular accumulation in ob/ob mice is accompanied by parallel increases in the activities of both DGAT I and DGAT II
DGAT2 expression is increased in diabetic mice.
leptin regulates adipocyte size by altering expression patterns of DGAT via central nervous system to determine the levels of triglyceride synthesis.
DGAT1 (show DGAT1 Proteins) but not DGAT2 has a role in VLDL synthesis; increased plasma VLDL concentrations may promote obesity, whereas increased DGAT2 activity has a role in steatosis
Data showed the associations between SNPs in intron 6 and intron 7 of the bovine diacylglycerolacyltransferase (show DGAT1 Proteins) (DGAT2) gene and growth traits in purebred Nanyang cattle.
Study on the polymorphisms of DGAT2 gene in 92 Jiaxian red cattle show that genotype AB may have positive effect on body weight.
expression of a codon-optimized version of the DGAT2 gene is able to restore neutral lipid accumulation in the Saccharomyces cerevisiae mutant strain
Using immunogold technique, DGAT2 found in lipid bodies associated with microtubules; microtubules may participate in lipid biosynthesis as indicated by the presence of DGAT2. [DGAT2]
These results suggest that the 13bp indel polymorphism in the 3'-UTR of porcine DGAT2 most likely affects fat deposition by altering its expression in pigs.
The porcine CTNNBL1 (show CTNNBL1 Proteins) and DGAT2 genes affect porcine fat deposition and further investigation will be necessary to illustrate the underlying mechanisms.
This gene encodes one of two enzymes which catalyzes the final reaction in the synthesis of triglycerides in which diacylglycerol is covalently bound to long chain fatty acyl-CoAs. The encoded protein catalyzes this reaction at low concentrations of magnesium chloride while the other enzyme has high activity at high concentrations of magnesium chloride. Multiple transcript variants encoding different isoforms have been found for this gene.
diacylglycerol O-acyltransferase homolog 2
, diglyceride acyltransferase 2
, acyl-CoA retinol O-fatty-acyltransferase
, diacylglycerol O-acyltransferase-like protein 2
, retinol O-fatty-acyltransferase
, diacylglycerol acyltransferase 2
, putative diacylglycerol O-acyltransferase
, diacylglycerol acytransferase 2