Diaphanous Homolog 3 (Drosophila) Proteins (DIAPH3)

DIAPH3 encodes a member of the diaphanous subfamily of the formin family. Additionally we are shipping DIAPH3 Antibodies (60) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat DIAPH3 DIAPH3 290396  
DIAPH3 56419 Q9Z207
DIAPH3 81624 Q9NSV4
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Top DIAPH3 Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days

DIAPH3 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,

More Proteins for Diaphanous Homolog 3 (Drosophila) (DIAPH3) Interaction Partners

Mouse (Murine) Diaphanous Homolog 3 (Drosophila) (DIAPH3) interaction partners

  1. Ineffective erythropoiesis caused by binucleated late-stage erythroblasts in mDia2 hematopoietic specific knockout mice.

  2. the interactome of auto-inhibited and constitutively active mDia2, is reported.

  3. mDia2-deficient erythroid cells differentiate normally, though in a delayed manner, but exhibit cytokinesis failure with decreased accumulation of F-actin in the cleavage furrow during late differentiation from proerythroblasts

  4. Diaphanous homolog 3 (Diap3) overexpression causes progressive hearing loss and inner hair cell defects in a transgenic mouse model of human deafness.

  5. Dia1 and Dia2 are dynamic components of meiotic spindle and pole complex during meiotic maturation of oocytes.

  6. Microtubules strongly inhibit actin polymerization by mDia2.

  7. Results indicate that ROCK-dependent phosphorylation of the mDia2 DAD is an important determinant of mDia2 activity and that this signalling mechanism affects actin polymerization and smooth muscle cell-specific gene expression.

  8. Results show that targeting of mDia2 to the cleavage furrow requires not only its binding to RhoA (show RHOA Proteins) but also its diaphanous-inhibitory domain, and identify anillin (show ANLN Proteins) as a novel mDia2 interaction partner.

  9. Int (show TSC22D3 Proteins)roduction of the mDia2 inhibitor DIP/WISH/SPIN90 into cells triggers non-apoptotic membrane blebbing. The results infer a role for mDia2 in (show ACTR2 Proteins)the maintenance of actin networks supporting the cell cortex.

  10. the bundling activities of FRL1 and mDia2, while producing phenotypically similar bundles, differ in mechanistic detail

Human Diaphanous Homolog 3 (Drosophila) (DIAPH3) interaction partners

  1. mDia2 and CXCR4 (show CXCR4 Proteins) associate in blebs upon CXCL12 (show CXCL12 Proteins) stimulation. Both CXCR4 (show CXCR4 Proteins) and RhoA (show RHOA Proteins) are required for CXCL12 (show CXCL12 Proteins)-induced blebbing

  2. we use a simple cellular system to examine fundamental features of formin (show FMN1 Proteins)-mediated filopodial assembly, using constitutively active constructs of the formins mDia2 and FMNL3 (show FMNL3 Proteins)

  3. results suggest that inhibition of MT stability arising from DIAPH3 downregulation enhances susceptibility to MT poisons, and that the DIAPH3 network potentially reports taxane sensitivity in human tumors

  4. Dia1 (show CYB5R3 Proteins), Dia2, and Dia3 are involved in ErbB2 (show ERBB2 Proteins)-dependent capture of microtubules at the cell leading edge and ErbB2 (show ERBB2 Proteins)-driven guided migration.

  5. An mDia2/ROCK signaling axis regulates invasive egress from epithelial ovarian cancer spheroids.

  6. TGF-beta promotes association of mDia2 with actin stress fibers, which further drives stress fiber formation and myofibroblast differentiation

  7. In human tumours, DIAPH3 down-regulation was associated with aggressive or metastatic disease.

  8. isoform-selective actin assembly by DIAPH3 exerts specific and differentially regulated functions during cell adhesion and motility.

  9. the amino terminus of mDia2 serves as a coincidence detection module, directing mDia2 to the plasma membrane through interactions with phospholipids and activated Rif

  10. These findings reveal a key role for mDia3 and its regulation by Aurora B (show AURKB Proteins) phosphorylation in achieving proper stable kinetochore microtubule attachment.

DIAPH3 Protein Profile

Protein Summary

This gene encodes a member of the diaphanous subfamily of the formin family. Members of this family are involved in actin remodeling and regulate cell movement and adhesion. Mutations in this gene are associated with autosomal dominant auditory neuropathy 1. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with DIAPH3

  • diaphanous-related formin 3 (Diaph3)
  • diaphanous homolog 3 (Drosophila) (DIAPH3)
  • diaphanous-related formin 3 (DIAPH3)
  • diaphanous homolog 3 (Drosophila) (Diap3)
  • 4930417P13Rik protein
  • AN protein
  • AUNA1 protein
  • DIA2 protein
  • diap3 protein
  • Diaph3 protein
  • DRF3 protein
  • mDia2 protein
  • mKIAA4117 protein
  • NSDAN protein
  • p134MDia2 protein

Protein level used designations for DIAPH3

diaphanous homolog 3 , protein diaphanous homolog 3 , diaphanous homolog 3 (Drosophila) , protein diaphanous homolog 3-like , diaphanous-related formin , diaphanous-related formin-3

290396 Rattus norvegicus
418824 Gallus gallus
100174272 Pongo abelii
485474 Canis lupus familiaris
525628 Bos taurus
452752 Pan troglodytes
100051814 Equus caballus
100011744 Monodelphis domestica
100475459 Ailuropoda melanoleuca
100517419 Sus scrofa
56419 Mus musculus
81624 Homo sapiens
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