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DISC1 encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. Additionally we are shipping DISC1 Proteins (8) and DISC1 Kits (3) and many more products for this protein.
Showing 10 out of 166 products:
Human Polyclonal DISC1 Primary Antibody for EIA, IF - ABIN499748
Morris, Kandpal, Ma, Austin: DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation. in Human molecular genetics 2003
Show all 4 references for ABIN499748
Human Polyclonal DISC1 Primary Antibody for EIA, FACS - ABIN951917
Park, Jeong, Lee, Mun, Kim, Lee, Nguyen, Han, Suh, Park: Disrupted-in-schizophrenia 1 (DISC1) plays essential roles in mitochondria in collaboration with Mitofilin. in Proceedings of the National Academy of Sciences of the United States of America 2010
Show all 3 references for ABIN951917
Human Polyclonal DISC1 Primary Antibody for FACS, IHC (p) - ABIN658716
Raznahan, Lee, Long, Greenstein, Clasen, Addington, Rapoport, Giedd: Common functional polymorphisms of DISC1 and cortical maturation in typically developing children and adolescents. in Molecular psychiatry 2011
Show all 3 references for ABIN658716
Human Polyclonal DISC1 Primary Antibody for EIA, WB - ABIN492932
Camargo, Wang, Brandon: What can we learn from the disrupted in schizophrenia 1 interactome: lessons for target identification and disease biology? in Novartis Foundation symposium 2008
Show all 3 references for ABIN492932
Human Polyclonal DISC1 Primary Antibody for ELISA, WB - ABIN190904
Millar, Pickard, Mackie, James, Christie, Buchanan, Malloy, Chubb, Huston, Baillie, Thomson, Hill, Brandon, Rain, Camargo, Whiting, Houslay, Blackwood, Muir, Porteous: DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling. in Science (New York, N.Y.) 2005
A Disc1 peptide binds to GSK3beta (show GSK3b Antibodies), and Disc1 directs early brain development and neurogenesis, by promoting beta-catenin (show CTNNB1 Antibodies)-mediated Wnt (show WNT2 Antibodies) signaling and inhibiting GSK3beta (show GSK3b Antibodies) activity.
Disc1 and nrg1 (show NRG1 Antibodies) function in controlling development of oligodendrocytes and neurones from olig2 (show OLIG2 Antibodies)-expressing precursor cells.
Disc1 functions in the transcriptional repression of foxd3 (show FOXD3 Antibodies) and sox10 (show SOX10 Antibodies), thus mediating cranial neural crest cell migration and differentiation.
Hypoxic preconditioning decreases NF-kappaB (show NFKB1 Antibodies) activity via DISC1.
Results suggest that DISC1 interacts with BA (show APP Antibodies)CE1 and promotes lysosomal degradation of (show APP Antibodies) BAC (show PSEN1 Antibodies)E1, thus reducing the generation of Abeta
It is anterogradely transported to the neurite tips, together with Lis1 (show PAFAH1B1 Antibodies), and functions in neurite extension via suppression of GSK3beta (show GSK3b Antibodies) activity.
DISC1 disruption affects expression of neural cell fate markers and Wnt (show WNT2 Antibodies) signaling.
These results uncover an unexpected role for DISC1 in normal beta-cell physiology and suggest that DISC1 dysregulation contributes to T2D independently of its importance for cognition.
DISC1 gene variations may affect the course of cognitive deficits found in patients suffering from the first episode of non-affective psychosis
DISC1 acts as an important regulator of mitochondrial dynamics in both axons and dendrites.
An association was found with DISC1 genetic variants and susceptibility to schizophrenia in a Han Chinese population.
Results indicate that the neurexin (show NRXN1 Antibodies) and neuroligin synaptic complex is intrinsically involved in the regulation of DISC1 function, thus contributing to a better understanding of the pathology of schizophrenia.
Results with immature neurons from patients with schizophrenia and bipolar disorder showed common alterations in DISC1 levels and its cellular distribution, cAMP homeostasis, and cell migration
Systematic investigation suggests that DISC1 is present in several cellular compartments, including synapses, where it interacts with a wider molecular network to mediate cellular and synaptic function.
Hypoxic preconditioning decreases NF-kappaB (show NFKB1 Antibodies) activity via Disc1.
Results indicate that DISC1 attenuates Abeta (show APP Antibodies) generation and cognitive deficits of APP (show APP Antibodies)/PS1 (show PSEN1 Antibodies) transgenic mice through promoting lysosomal degradation of BACE1 (show BACE Antibodies)
These results suggest that alteration of CB1R (show CNR1 Antibodies)-mediated signaling in DN-DISC1 mice may underlie susceptibility to detrimental effects of adolescent cannabis exposure on adult behaviors.
These results suggest a mechanism by which cross-talk between DISC1 and NRG1 (show NRG1 Antibodies)-ErbB4 (show ERBB4 Antibodies) signalling may contribute to these deficits.
Study found that DISC1 influences APP (show APP Antibodies) C-terminal processing and Abeta (show APP Antibodies) peptide generation, affects surface expression and internalization of APP (show APP Antibodies) in neurons
DISC1 regulates the expression of brain neurotrophin (show BDNF Antibodies) VGF (show VGF Antibodies) through the PI3K/AKT (show AKT1 Antibodies)/CREB (show CREB1 Antibodies) pathway.
Disc1 truncation in Disc1tr Hemi mice induces a range of translationally relevant endophenotypes underpinned by glutamate (show GRIN1 Antibodies) system dysfunction and altered brain connectivity.
DISC1 is a regulatory factor in ER calcium dynamics, linking a perturbed intracellular calcium signaling and schizophrenia pathogenesis.
This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1\;11)(q42.1\;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
disrupted in schizophrenia 1 protein
, disrupted in schizophrenia 1
, disrupted in schizophrenia 1 homolog