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anti-Disrupted in Schizophrenia 1 (DISC1) Antibodies

DISC1 encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. Additionally we are shipping DISC1 Proteins (8) and DISC1 Kits (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DISC1 27185 Q9NRI5
DISC1 244667 Q811T9
DISC1 307940 Q810H6
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Top anti-DISC1 Antibodies at antibodies-online.com

Showing 10 out of 194 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, FACS, IHC (p), WB Flow cytometric analysis of CEM cells using DISC1 Antibody (C-term) Cat.-No AP51267PU-N (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Formalin fixed and paraffin embedded human brain tissue reacted with DISC1 Antibody (C-term) followed by peroxidase conjugation of the secondary antibody and DAB staining. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Goat Un-conjugated ELISA, WB ABIN190904 (0.1µg/ml) staining of human brain (hippocampus) lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 4 to 5 Days
$326.89
Details
Human Rabbit Un-conjugated EIA, IF, WB Immunocytochemistry of DISC1 in HeLa cells with AP30292PU-N DISC1 antibody at 5 μg/ml. Western blot analysis of DISC1 in SK-N-SH cell lysate with AP30292PU-N DISC1 antibody at (A) 0.5, (B) 1 and (C) 2 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Mouse Rabbit Un-conjugated ICC, IHC (fro), IF, IHC (p), IHC Staining of neurons, glial cells, and white matter using ABIN258331.  Mouse brain, 40X Immunocytochemistry/Immunofluorescence: DISC1 Antibody [ABIN2583315] - DISC1 antibody was tested in PC-12 cells at 1:100 with Dylight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 549 (red). 0.1 mL Log in to see 5 to 7 Days
$381.94
Details
Human Rabbit Un-conjugated ICC, IHC (fro), IF, IHC (p), IHC Staining of neurons and neuropil using ABIN258328 at 2.5ug/ml.  Human  brain, 40X. Immunocytochemistry/Immunofluorescence: DISC1 Antibody [ABIN2583283] - DISC1 antibody was tested in PC-12 cells at 1:100 with Dylight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 549 (red). 0.1 mL Log in to see 5 to 7 Days
$381.94
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB DISC1 Antibody (C-term) (ABIN658716) western blot analysis in Ramos cell line lysates (35 µg/lane). This demonstrates the DISC1 antibody detected the DISC1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB   0.1 mg Log in to see 6 to 8 Days
$456.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated IF, WB 0.1 mg Log in to see 6 to 8 Days
$357.50
Details
Mouse Rabbit Un-conjugated EIA, IHC (p), WB 50 μg Log in to see 6 to 8 Days
$500.50
Details

DISC1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-DISC1 Antibodies

  1. Human Polyclonal DISC1 Primary Antibody for EIA, IF - ABIN499748 : Morris, Kandpal, Ma, Austin: DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation. in Human molecular genetics 2003 (PubMed)
    Show all 4 references for ABIN499748

  2. Human Polyclonal DISC1 Primary Antibody for FACS, IHC (p) - ABIN658716 : Park, Jeong, Lee, Mun, Kim, Lee, Nguyen, Han, Suh, Park: Disrupted-in-schizophrenia 1 (DISC1) plays essential roles in mitochondria in collaboration with Mitofilin. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)
    Show all 3 references for ABIN658716

  3. Human Polyclonal DISC1 Primary Antibody for EIA, WB - ABIN492932 : Camargo, Wang, Brandon: What can we learn from the disrupted in schizophrenia 1 interactome: lessons for target identification and disease biology? in Novartis Foundation symposium 2008 (PubMed)
    Show all 3 references for ABIN492932

  4. Human Polyclonal DISC1 Primary Antibody for EIA, FACS - ABIN951917 : Kaibuchi, Tsuboi: [Current perspective on the pathogenesis of schizophrenia from the viewpoint of risk factors such as DISC1 (corrected)]. in Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 2010 (PubMed)
    Show all 3 references for ABIN951917

  5. Mouse (Murine) Polyclonal DISC1 Primary Antibody for ICC, IHC (fro) - ABIN258331 : El-Hassar, Simen, Duque, Patel, Kaczmarek, Arnsten, Yeckel: Disrupted in schizophrenia 1 modulates medial prefrontal cortex pyramidal neuron activity through cAMP regulation of transient receptor potential C and small-conductance K+ channels. in Biological psychiatry 2014 (PubMed)

  6. Human Polyclonal DISC1 Primary Antibody for ELISA, WB - ABIN190904 : Millar, Pickard, Mackie, James, Christie, Buchanan, Malloy, Chubb, Huston, Baillie, Thomson, Hill, Brandon, Rain, Camargo, Whiting, Houslay, Blackwood, Muir, Porteous: DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling. in Science (New York, N.Y.) 2005 (PubMed)

More Antibodies against DISC1 Interaction Partners

Zebrafish Disrupted in Schizophrenia 1 (DISC1) interaction partners

  1. A Disc1 peptide binds to GSK3beta (show GSK3b Antibodies), and Disc1 directs early brain development and neurogenesis, by promoting beta-catenin (show CTNNB1 Antibodies)-mediated Wnt (show WNT2 Antibodies) signaling and inhibiting GSK3beta (show GSK3b Antibodies) activity.

  2. Disc1 and nrg1 (show NRG1 Antibodies) function in controlling development of oligodendrocytes and neurones from olig2 (show OLIG2 Antibodies)-expressing precursor cells.

  3. Disc1 functions in the transcriptional repression of foxd3 (show FOXD3 Antibodies) and sox10 (show SOX10 Antibodies), thus mediating cranial neural crest cell migration and differentiation.

Human Disrupted in Schizophrenia 1 (DISC1) interaction partners

  1. This population-based case-control study was carried out to determine whether polymorphisms in DISC1 and NRG1 (show NRG1 Antibodies) genes could be associated with schizophrenia in the Chinese population.

  2. This study demonstrated that the Increased density of DISC1-immunoreactive oligodendroglial cells in fronto-parietal white matter of patients with paranoid schizophrenia.

  3. The present findings, at least in part, provide some clues for further investigating the association of DISC1 variants with SCZ susceptibility

  4. DISC1 may be involved in sleep regulation

  5. Polymorphisms in DISC1 play a role in vulnerability to opioid dependence in a Polish sample.

  6. Hypoxic preconditioning decreases NF-kappaB (show NFKB1 Antibodies) activity via DISC1.

  7. Results suggest that DISC1 interacts with BA (show APP Antibodies)CE1 and promotes lysosomal degradation of (show APP Antibodies) BAC (show PSEN1 Antibodies)E1, thus reducing the generation of Abeta

  8. It is anterogradely transported to the neurite tips, together with Lis1 (show PAFAH1B1 Antibodies), and functions in neurite extension via suppression of GSK3beta (show GSK3b Antibodies) activity.

  9. DISC1 disruption affects expression of neural cell fate markers and Wnt (show WNT2 Antibodies) signaling.

  10. These results uncover an unexpected role for DISC1 in normal beta-cell physiology and suggest that DISC1 dysregulation contributes to T2D independently of its importance for cognition.

Mouse (Murine) Disrupted in Schizophrenia 1 (DISC1) interaction partners

  1. abnormality in hippocampal activity at the goal zone during the task may underlie the learning deficit observed in the DISC1 mutant mice.

  2. Missense mutation in DISC1 C-terminal coiled-coil has GSK3beta (show GSK3b Antibodies) signaling and sex-dependent behavioral effects in mice

  3. Systematic investigation suggests that DISC1 is present in several cellular compartments, including synapses, where it interacts with a wider molecular network to mediate cellular and synaptic function.

  4. Hypoxic preconditioning decreases NF-kappaB (show NFKB1 Antibodies) activity via Disc1.

  5. Results indicate that DISC1 attenuates Abeta (show APP Antibodies) generation and cognitive deficits of APP (show APP Antibodies)/PS1 (show PSEN1 Antibodies) transgenic mice through promoting lysosomal degradation of BACE1 (show BACE Antibodies)

  6. These results suggest that alteration of CB1R (show CNR1 Antibodies)-mediated signaling in DN-DISC1 mice may underlie susceptibility to detrimental effects of adolescent cannabis exposure on adult behaviors.

  7. These results uncover an unexpected role for DISC1 in normal beta-cell physiology and suggest that DISC1 dysregulation contributes to T2D independently of its importance for cognition.

  8. These results suggest a mechanism by which cross-talk between DISC1 and NRG1 (show NRG1 Antibodies)-ErbB4 (show ERBB4 Antibodies) signalling may contribute to these deficits.

  9. Study found that DISC1 influences APP (show APP Antibodies) C-terminal processing and Abeta (show APP Antibodies) peptide generation, affects surface expression and internalization of APP (show APP Antibodies) in neurons

  10. DISC1 regulates the expression of brain neurotrophin (show BDNF Antibodies) VGF (show VGF Antibodies) through the PI3K/AKT (show AKT1 Antibodies)/CREB (show CREB1 Antibodies) pathway.

DISC1 Antigen Profile

Protein Summary

This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1\;11)(q42.1\;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene names and symbols associated with DISC1

  • disrupted in schizophrenia 1 (disc1) antibody
  • disrupted in schizophrenia 1 (DISC1) antibody
  • disrupted in schizophrenia 1 (Disc1) antibody
  • C1orf136 antibody
  • DISC1 antibody
  • SCZD9 antibody

Protein level used designations for DISC1

disrupted in schizophrenia 1 protein , disrupted in schizophrenia 1 , disrupted in schizophrenia 1 homolog

GENE ID SPECIES
407621 Danio rerio
719086 Macaca mulatta
742093 Pan troglodytes
100060246 Equus caballus
488970 Canis lupus familiaris
613555 Bos taurus
100156849 Sus scrofa
100356059 Oryctolagus cuniculus
100580606 Nomascus leucogenys
27185 Homo sapiens
244667 Mus musculus
307940 Rattus norvegicus
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