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DISC1 encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. Additionally we are shipping DISC1 Proteins (9) and DISC1 Kits (3) and many more products for this protein.
Showing 10 out of 195 products:
Human Polyclonal DISC1 Primary Antibody for EIA, IF - ABIN499748
Morris, Kandpal, Ma, Austin: DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation. in Human molecular genetics 2003
Show all 4 references for ABIN499748
Human Polyclonal DISC1 Primary Antibody for FACS, IHC (p) - ABIN658716
Park, Jeong, Lee, Mun, Kim, Lee, Nguyen, Han, Suh, Park: Disrupted-in-schizophrenia 1 (DISC1) plays essential roles in mitochondria in collaboration with Mitofilin. in Proceedings of the National Academy of Sciences of the United States of America 2010
Show all 3 references for ABIN658716
Human Polyclonal DISC1 Primary Antibody for EIA, WB - ABIN492932
Camargo, Wang, Brandon: What can we learn from the disrupted in schizophrenia 1 interactome: lessons for target identification and disease biology? in Novartis Foundation symposium 2008
Show all 3 references for ABIN492932
Human Polyclonal DISC1 Primary Antibody for EIA, FACS - ABIN951917
Kaibuchi, Tsuboi: [Current perspective on the pathogenesis of schizophrenia from the viewpoint of risk factors such as DISC1 (corrected)]. in Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 2010
Show all 3 references for ABIN951917
Human Polyclonal DISC1 Primary Antibody for ICC, IHC (fro) - ABIN258328
El-Hassar, Simen, Duque, Patel, Kaczmarek, Arnsten, Yeckel: Disrupted in schizophrenia 1 modulates medial prefrontal cortex pyramidal neuron activity through cAMP regulation of transient receptor potential C and small-conductance K+ channels. in Biological psychiatry 2014
Human Polyclonal DISC1 Primary Antibody for ELISA, WB - ABIN190904
Millar, Pickard, Mackie, James, Christie, Buchanan, Malloy, Chubb, Huston, Baillie, Thomson, Hill, Brandon, Rain, Camargo, Whiting, Houslay, Blackwood, Muir, Porteous: DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling. in Science (New York, N.Y.) 2005
A Disc1 peptide binds to GSK3beta (show GSK3b Antibodies), and Disc1 directs early brain development and neurogenesis, by promoting beta-catenin (show CTNNB1 Antibodies)-mediated Wnt (show WNT2 Antibodies) signaling and inhibiting GSK3beta (show GSK3b Antibodies) activity.
Disc1 and nrg1 (show NRG1 Antibodies) function in controlling development of oligodendrocytes and neurones from olig2 (show OLIG2 Antibodies)-expressing precursor cells.
Disc1 functions in the transcriptional repression of foxd3 (show FOXD3 Antibodies) and sox10 (show SOX10 Antibodies), thus mediating cranial neural crest cell migration and differentiation.
This population-based case-control study was carried out to determine whether polymorphisms in DISC1 and NRG1 (show NRG1 Antibodies) genes could be associated with schizophrenia in the Chinese population.
This study demonstrated that the Increased density of DISC1-immunoreactive oligodendroglial cells in fronto-parietal white matter of patients with paranoid schizophrenia.
The present findings, at least in part, provide some clues for further investigating the association of DISC1 variants with SCZ susceptibility
DISC1 may be involved in sleep regulation
Polymorphisms in DISC1 play a role in vulnerability to opioid dependence in a Polish sample.
Hypoxic preconditioning decreases NF-kappaB (show NFKB1 Antibodies) activity via DISC1.
Results suggest that DISC1 interacts with BA (show APP Antibodies)CE1 and promotes lysosomal degradation of (show APP Antibodies) BAC (show PSEN1 Antibodies)E1, thus reducing the generation of Abeta
It is anterogradely transported to the neurite tips, together with Lis1 (show PAFAH1B1 Antibodies), and functions in neurite extension via suppression of GSK3beta (show GSK3b Antibodies) activity.
DISC1 disruption affects expression of neural cell fate markers and Wnt (show WNT2 Antibodies) signaling.
These results uncover an unexpected role for DISC1 in normal beta-cell physiology and suggest that DISC1 dysregulation contributes to T2D independently of its importance for cognition.
abnormality in hippocampal activity at the goal zone during the task may underlie the learning deficit observed in the DISC1 mutant mice.
Missense mutation in DISC1 C-terminal coiled-coil has GSK3beta (show GSK3b Antibodies) signaling and sex-dependent behavioral effects in mice
Systematic investigation suggests that DISC1 is present in several cellular compartments, including synapses, where it interacts with a wider molecular network to mediate cellular and synaptic function.
Hypoxic preconditioning decreases NF-kappaB (show NFKB1 Antibodies) activity via Disc1.
Results indicate that DISC1 attenuates Abeta (show APP Antibodies) generation and cognitive deficits of APP (show APP Antibodies)/PS1 (show PSEN1 Antibodies) transgenic mice through promoting lysosomal degradation of BACE1 (show BACE Antibodies)
These results suggest that alteration of CB1R (show CNR1 Antibodies)-mediated signaling in DN-DISC1 mice may underlie susceptibility to detrimental effects of adolescent cannabis exposure on adult behaviors.
These results suggest a mechanism by which cross-talk between DISC1 and NRG1 (show NRG1 Antibodies)-ErbB4 (show ERBB4 Antibodies) signalling may contribute to these deficits.
Study found that DISC1 influences APP (show APP Antibodies) C-terminal processing and Abeta (show APP Antibodies) peptide generation, affects surface expression and internalization of APP (show APP Antibodies) in neurons
DISC1 regulates the expression of brain neurotrophin (show BDNF Antibodies) VGF (show VGF Antibodies) through the PI3K/AKT (show AKT1 Antibodies)/CREB (show CREB1 Antibodies) pathway.
This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1\;11)(q42.1\;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
disrupted in schizophrenia 1 protein
, disrupted in schizophrenia 1
, disrupted in schizophrenia 1 homolog