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anti-Disrupted in Schizophrenia 1 (DISC1) Antibodies

DISC1 encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. Additionally we are shipping DISC1 Proteins (8) and DISC1 Kits (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DISC1 27185 Q9NRI5
DISC1 244667 Q811T9
DISC1 307940 Q810H6
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Top anti-DISC1 Antibodies at antibodies-online.com

Showing 10 out of 166 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, FACS, IHC (p), WB Flow cytometric analysis of CEM cells using DISC1 Antibody (C-term) Cat.-No AP51267PU-N (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Formalin fixed and paraffin embedded human brain tissue reacted with DISC1 Antibody (C-term) followed by peroxidase conjugation of the secondary antibody and DAB staining. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Goat Un-conjugated ELISA, WB ABIN190904 (0.1µg/ml) staining of human brain (hippocampus) lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Rabbit Un-conjugated EIA, IF, WB Immunocytochemistry of DISC1 in HeLa cells with AP30292PU-N DISC1 antibody at 5 μg/ml. Western blot analysis of DISC1 in SK-N-SH cell lysate with AP30292PU-N DISC1 antibody at (A) 0.5, (B) 1 and (C) 2 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB DISC1 Antibody (C-term) (ABIN658716) western blot analysis in Ramos cell line lysates (35 µg/lane). This demonstrates the DISC1 antibody detected the DISC1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB   0.1 mg Log in to see 6 to 8 Days
$456.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 8 to 10 Days
$507.83
Details
Human Rabbit Un-conjugated IF, WB 0.1 mg Log in to see 6 to 8 Days
$357.50
Details
Mouse Rabbit Un-conjugated IHC (p), ELISA, WB Human Brain, Cerebellum (formalin-fixed, paraffin-embedded) stained with DISC1 antibody ABIN351527 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 8 to 10 Days
$451.00
Details
Mouse Rabbit Un-conjugated EIA, IHC (p), WB 50 μg Log in to see 6 to 8 Days
$500.50
Details

DISC1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-DISC1 Antibodies

  1. Human Polyclonal DISC1 Primary Antibody for EIA, IF - ABIN499748 : Morris, Kandpal, Ma, Austin: DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation. in Human molecular genetics 2003 (PubMed)
    Show all 4 references for ABIN499748

  2. Human Polyclonal DISC1 Primary Antibody for EIA, FACS - ABIN951917 : Park, Jeong, Lee, Mun, Kim, Lee, Nguyen, Han, Suh, Park: Disrupted-in-schizophrenia 1 (DISC1) plays essential roles in mitochondria in collaboration with Mitofilin. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)
    Show all 3 references for ABIN951917

  3. Human Polyclonal DISC1 Primary Antibody for FACS, IHC (p) - ABIN658716 : Raznahan, Lee, Long, Greenstein, Clasen, Addington, Rapoport, Giedd: Common functional polymorphisms of DISC1 and cortical maturation in typically developing children and adolescents. in Molecular psychiatry 2011 (PubMed)
    Show all 3 references for ABIN658716

  4. Human Polyclonal DISC1 Primary Antibody for EIA, WB - ABIN492932 : Camargo, Wang, Brandon: What can we learn from the disrupted in schizophrenia 1 interactome: lessons for target identification and disease biology? in Novartis Foundation symposium 2008 (PubMed)
    Show all 3 references for ABIN492932

  5. Human Polyclonal DISC1 Primary Antibody for ELISA, WB - ABIN190904 : Millar, Pickard, Mackie, James, Christie, Buchanan, Malloy, Chubb, Huston, Baillie, Thomson, Hill, Brandon, Rain, Camargo, Whiting, Houslay, Blackwood, Muir, Porteous: DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling. in Science (New York, N.Y.) 2005 (PubMed)

More Antibodies against DISC1 Interaction Partners

Zebrafish Disrupted in Schizophrenia 1 (DISC1) interaction partners

  1. A Disc1 peptide binds to GSK3beta (show GSK3b Antibodies), and Disc1 directs early brain development and neurogenesis, by promoting beta-catenin (show CTNNB1 Antibodies)-mediated Wnt (show WNT2 Antibodies) signaling and inhibiting GSK3beta (show GSK3b Antibodies) activity.

  2. Disc1 and nrg1 (show NRG1 Antibodies) function in controlling development of oligodendrocytes and neurones from olig2 (show OLIG2 Antibodies)-expressing precursor cells.

  3. Disc1 functions in the transcriptional repression of foxd3 (show FOXD3 Antibodies) and sox10 (show SOX10 Antibodies), thus mediating cranial neural crest cell migration and differentiation.

Human Disrupted in Schizophrenia 1 (DISC1) interaction partners

  1. Hypoxic preconditioning decreases NF-kappaB (show NFKB1 Antibodies) activity via DISC1.

  2. Results suggest that DISC1 interacts with BA (show APP Antibodies)CE1 and promotes lysosomal degradation of (show APP Antibodies) BAC (show PSEN1 Antibodies)E1, thus reducing the generation of Abeta

  3. It is anterogradely transported to the neurite tips, together with Lis1 (show PAFAH1B1 Antibodies), and functions in neurite extension via suppression of GSK3beta (show GSK3b Antibodies) activity.

  4. DISC1 disruption affects expression of neural cell fate markers and Wnt (show WNT2 Antibodies) signaling.

  5. These results uncover an unexpected role for DISC1 in normal beta-cell physiology and suggest that DISC1 dysregulation contributes to T2D independently of its importance for cognition.

  6. DISC1 gene variations may affect the course of cognitive deficits found in patients suffering from the first episode of non-affective psychosis

  7. DISC1 acts as an important regulator of mitochondrial dynamics in both axons and dendrites.

  8. An association was found with DISC1 genetic variants and susceptibility to schizophrenia in a Han Chinese population.

  9. Results indicate that the neurexin (show NRXN1 Antibodies) and neuroligin synaptic complex is intrinsically involved in the regulation of DISC1 function, thus contributing to a better understanding of the pathology of schizophrenia.

  10. Results with immature neurons from patients with schizophrenia and bipolar disorder showed common alterations in DISC1 levels and its cellular distribution, cAMP homeostasis, and cell migration

Mouse (Murine) Disrupted in Schizophrenia 1 (DISC1) interaction partners

  1. Systematic investigation suggests that DISC1 is present in several cellular compartments, including synapses, where it interacts with a wider molecular network to mediate cellular and synaptic function.

  2. Hypoxic preconditioning decreases NF-kappaB (show NFKB1 Antibodies) activity via Disc1.

  3. Results indicate that DISC1 attenuates Abeta (show APP Antibodies) generation and cognitive deficits of APP (show APP Antibodies)/PS1 (show PSEN1 Antibodies) transgenic mice through promoting lysosomal degradation of BACE1 (show BACE Antibodies)

  4. These results suggest that alteration of CB1R (show CNR1 Antibodies)-mediated signaling in DN-DISC1 mice may underlie susceptibility to detrimental effects of adolescent cannabis exposure on adult behaviors.

  5. These results uncover an unexpected role for DISC1 in normal beta-cell physiology and suggest that DISC1 dysregulation contributes to T2D independently of its importance for cognition.

  6. These results suggest a mechanism by which cross-talk between DISC1 and NRG1 (show NRG1 Antibodies)-ErbB4 (show ERBB4 Antibodies) signalling may contribute to these deficits.

  7. Study found that DISC1 influences APP (show APP Antibodies) C-terminal processing and Abeta (show APP Antibodies) peptide generation, affects surface expression and internalization of APP (show APP Antibodies) in neurons

  8. DISC1 regulates the expression of brain neurotrophin (show BDNF Antibodies) VGF (show VGF Antibodies) through the PI3K/AKT (show AKT1 Antibodies)/CREB (show CREB1 Antibodies) pathway.

  9. Disc1 truncation in Disc1tr Hemi mice induces a range of translationally relevant endophenotypes underpinned by glutamate (show GRIN1 Antibodies) system dysfunction and altered brain connectivity.

  10. DISC1 is a regulatory factor in ER calcium dynamics, linking a perturbed intracellular calcium signaling and schizophrenia pathogenesis.

DISC1 Antigen Profile

Protein Summary

This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1\;11)(q42.1\;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene names and symbols associated with DISC1

  • disrupted in schizophrenia 1 (disc1) antibody
  • disrupted in schizophrenia 1 (DISC1) antibody
  • disrupted in schizophrenia 1 (Disc1) antibody
  • C1orf136 antibody
  • DISC1 antibody
  • SCZD9 antibody

Protein level used designations for DISC1

disrupted in schizophrenia 1 protein , disrupted in schizophrenia 1 , disrupted in schizophrenia 1 homolog

GENE ID SPECIES
407621 Danio rerio
719086 Macaca mulatta
742093 Pan troglodytes
100060246 Equus caballus
488970 Canis lupus familiaris
613555 Bos taurus
100156849 Sus scrofa
100356059 Oryctolagus cuniculus
100580606 Nomascus leucogenys
27185 Homo sapiens
244667 Mus musculus
307940 Rattus norvegicus
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