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DnaJ (Hsp40) Homolog, Subfamily C, Member 5 Proteins (DNAJC5)

DNAJC5 is a member of the J protein family. Additionally we are shipping DNAJC5 Antibodies (101) and DNAJC5 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DNAJC5 80331 Q9H3Z4
DNAJC5 13002 P60904
DNAJC5 79130 P60905
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Top DNAJC5 Proteins at antibodies-online.com

Showing 8 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Torpedo californica His tag   1 mg Log in to see 56 to 66 Days
$2,469.50
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$2,476.83
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Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,480.50
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,480.50
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

DNAJC5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for DnaJ (Hsp40) Homolog, Subfamily C, Member 5 (DNAJC5) Interaction Partners

Fruit Fly (Drosophila melanogaster) DnaJ (Hsp40) Homolog, Subfamily C, Member 5 (DNAJC5) interaction partners

  1. This review summarizes studies that elucidate the neuroprotective role of Drosophila CSP, which is critical for maintaining neurotransmitter release and preventing neurodegeneration.

  2. these data suggest that CSP promotes synaptic growth and evoked neurotransmitter release by mechanistically independent signaling pathways

  3. study found dHIP14 to be an essential maternal effect gene required for photoreceptor synaptic transmission and for proper in vivo expression of the palmitoylated presynaptic proteins SNAP-25 (show SNAP25 Proteins) and cysteine string protein

  4. Our data indicate that HIP14 (show ZDHHC17 Proteins) controls neurotransmitter release by regulating the trafficking of CSP to synapses.

Xenopus laevis DnaJ (Hsp40) Homolog, Subfamily C, Member 5 (DNAJC5) interaction partners

  1. csp interaction with Hsc 70 (show HSPA8 Proteins) molecular chaperones is vital for regulated secretion in Xenopus oocytes

Human DnaJ (Hsp40) Homolog, Subfamily C, Member 5 (DNAJC5) interaction partners

  1. Missense mutations in DNAJC5 does not play a major role in PD in the Chinese population.

  2. Results indicate of a p.L116del mutation in DNAJC5 from families with autosomal dominant Kufs disease.

  3. Palmitoylation-induced aggregation of mutant CSP-alpha proteins may underlie the development of adult-onset neuronal ceroid lipofuscinosis (show CLN6 Proteins)

  4. association of DNAJC5 mutations with autosomal dominant Kufs disease

  5. This is the first replication study of the identification of DNAJC5 as the disease-causing gene for autosomal dominant ANCL. The identification of the novel gene in ANCL will allow us to gain a better understanding of the pathological mechanism of ANCLs

  6. First evidence that CSP and HSP70 (show HSP70 Proteins), and their interactions with MARCKS (show MARCKS Proteins), are involved in mucin (show SLC13A2 Proteins) secretion from airway epithelium.

  7. Csp not only regulates the exit of CFTR from the ER, but this action is accompanied by Hsc70/Hsp70 and CHIP-mediated CFTR degradation.

  8. Csp has a role in regulated CFTR (show CFTR Proteins) trafficking at the plasma membrane. [CYSTEINE STRING PROTEIN]

  9. Cysteine string protein inhibits N-type calcium channels, but is blocked by mutant huntingtin (show HTT Proteins)

  10. CSP modulates G protein function by preferentially targeting the inactive GDP-bound form of G alpha(s (show GNAS Proteins)) and promoting GDP/GTP (show AK3 Proteins) exchange; the guanine nucleotide exchange activity of full-length CSP is regulated by Hsc70 (show HSPA8 Proteins)-SGT (show SGTA Proteins)

Mouse (Murine) DnaJ (Hsp40) Homolog, Subfamily C, Member 5 (DNAJC5) interaction partners

  1. The mRNA and protein expression of CSP1 (show RCAN1 Proteins) was elevated in 3T3-L1 adipocytes in insulin (show INS Proteins) resistant states caused by high levels of palmitate and chronic insulin (show INS Proteins) exposure.

  2. gamma-Synuclein (show SNCG Proteins) binds synaptic vesicles but is unable to rescue the phenotype of CSPalpha-deficient mice.

  3. Using hippocampal cultures, study shows that CSPalpha regulates the stability of client proteins and synaptic vesicle number. Analysis of CSPalpha-dynamin 1 (show DNM1 Proteins) interactions reveals unexpectedly that CSPalpha regulates the polymerization of dynamin 1 (show DNM1 Proteins).

  4. Study shows that cysteine string protein-alpha is required to maintain the size of the releasable pool of synaptic vesicles in motorneurons, presumably by conveying stability to SNAP-25 (show SNAP25 Proteins).

  5. findings suggest that the neurodegeneration in CSPalpha KO mice is primarily produced by defective SNAP-25 (show SNAP25 Proteins) function, which causes neurodegeneration by impairing SNARE (show VTI1B Proteins)-complex assembly

  6. Data indicate that Cspalpha interacts with Syt9, and such a complex may be relevant in the calcium-mediated control of a late stage of exocytosis by triggering the specific recruitment of a folding catalyst at the fusion point.

  7. Data show that deletion of CSPalpha produces an abnormal SNAP-25 (show SNAP25 Proteins) conformer that inhibits SNARE (show VTI1B Proteins)-complex formation, and is subject to ubiquitylation and proteasomal degradation.

  8. CSPalpha is not essential for the normal operation of Ca2 (show CA2 Proteins)+ channels or exocytosis but acts as a presynaptic chaperone that maintains continued synaptic function. Its deletion causes postnatal lethality of knockout mice.

  9. Tonically active ribbon synapses in retina are particularly sensitive to the deletion of CSPalpha and that expression of at least one CSP isoform is essential to protect such tonically active synapses from neurodegeneration.

  10. palmitoylation of CSP is enhanced specifically by co-expression of the Golgi-localized palmitoyl transferases DHHC3, DHHC7, DHHC15 (show ZDHHC15 Proteins), or DHHC17 (show ZDHHC17 Proteins)

DNAJC5 Protein Profile

Protein Summary

This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. The encoded protein plays a role in membrane trafficking and protein folding, and has been shown to have anti-neurodegenerative properties. The encoded protein is known to play a role in cystic fibrosis and Huntington's disease. A pseudogene of this gene is located on the short arm of chromosome 8.

Gene names and symbols associated with DNAJC5

  • Cysteine string protein (Csp)
  • cysteine string protein (Csp)
  • cysteine string protein (SJAG_04371)
  • DnaJ (Hsp40) homolog, subfamily C, member 5aa (dnajc5aa)
  • DnaJ (Hsp40) homolog, subfamily C, member 5 gamma (dnajc5g)
  • cysteine string protein (Tsp_06120)
  • DnaJ (Hsp40) homolog, subfamily C, member 5 (DNAJC5)
  • DnaJ (Hsp40) homolog, subfamily C, member 5 (Dnajc5)
  • DnaJ (Hsp40) homolog, subfamily C, member 5 beta (dnajc5b)
  • 2610314I24Rik protein
  • ab49 protein
  • anon-WO02059370.50 protein
  • AU018536 protein
  • cb995 protein
  • CG6395 protein
  • CLN4 protein
  • CLN4B protein
  • Csp protein
  • csp-beta protein
  • csp29 protein
  • csp32 protein
  • Cys protein
  • D-CSP protein
  • D.M.CSP protein
  • Dcsp protein
  • DCSP-1 protein
  • Dmel\\CG6395 protein
  • DNAJC5 protein
  • DNAJC5A protein
  • GB10835 protein
  • l(3)03988 protein
  • MAB ab49 protein
  • NCL protein
  • zgc:92898 protein

Protein level used designations for DNAJC5

CG6395-PA , CG6395-PB , CG6395-PC , CG6395-PD , CG6395-PE , Csp-PA , Csp-PB , Csp-PC , Csp-PD , Csp-PE , cystein string protein , cysteine string protein , cysteine string protein 3 , cysteine-string protein , DnaJ (Hsp40) homolog, subfamily C, member 5 , cysteine string protein alpha , dnaJ homolog subfamily C member 5 , CSP , xcsp

GENE ID SPECIES
40459 Drosophila melanogaster
100159337 Acyrthosiphon pisum
724965 Apis mellifera
7050923 Schizosaccharomyces japonicus yFS275
386768 Danio rerio
447223 Xenopus laevis
10911532 Trichinella spiralis
448068 Xenopus (Silurana) tropicalis
485982 Canis lupus familiaris
80331 Homo sapiens
13002 Mus musculus
79130 Rattus norvegicus
282216 Bos taurus
399123 Xenopus laevis
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