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DNAJB12 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. Additionally we are shipping DNAJB12 Antibodies (54) and many more products for this protein.
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ER-located J-protein chaperones were identified as key regulators for the iogenesis and physiological function of ERG (show ERG Proteins) K+ channels. They regulate two distinct aspects of K+ channel (show KCNC4 Proteins) biogenesis, the stabilization and assembly of channel subunits.
Data suggest that endoplasmic reticulum (ER) stress-induced apoptosis in hepatoma cells is regulated by highly labile and ER-associated BCL-2 (show BCL2 Proteins) family member BOK (show BOK Proteins), which is controlled at level of protein stability by ER-associated degradation components; DNAJB12 is required in hepatoma cells to maintain BOK (show BOK Proteins) at low levels and suppress ER stress. (DNAJB12 = DnaJ (Hsp40 (show DNAJB1 Proteins)) homolog (show DNAJB4 Proteins), subfamily B, member 12)
Over-expression of DNAJB12 or DNAJB14 (show DNAJB14 Proteins) causes the formation of elaborate membranous structures within cell nuclei, designated DJANGOS for DNAJ (show DNAJB6 Proteins)-associated nuclear globular structures.
JB12 cooperates with cytosolic Hsc70 (show HSPA8 Proteins) and the ubiquitin ligase RMA1 to target CFTR (show CFTR Proteins) and CFTRDeltaF508 for degradation.
DNAJB12 is a novel mammalian ER-localized J-protein that plays a vital role in the quality control of membrane proteins
DNAJB12 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus\; a glycine/phenylalanine (G/F)-rich region\; and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain (Ohtsuka and Hata, 2000
DnaJ (Hsp40) homolog, subfamily B, member 12
, dnaJ homolog subfamily B member 12
, dnaJ homolog subfamily B member 12-like
, DnaJ homolog 10