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The protein encoded by DOK1 is part of a signal transduction pathway downstream of receptor tyrosine kinases. Additionally we are shipping DOK1 Kits (11) and DOK1 Proteins (11) and many more products for this protein.
Showing 10 out of 227 products:
Human Monoclonal DOK1 Primary Antibody for IF, IP - ABIN968157
Carpino, Wisniewski, Strife, Marshak, Kobayashi, Stillman, Clarkson: p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells. in Cell 1997
Show all 5 references for ABIN968157
Human Polyclonal DOK1 Primary Antibody for EIA, IHC (p) - ABIN359958
Liang, Wisniewski, Strife, Shivakrupa, Clarkson, Resh: Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling. in The Journal of biological chemistry 2002
Show all 5 references for ABIN359958
Human Polyclonal DOK1 Primary Antibody for IHC (p), WB - ABIN392070
Yamakawa, Tsuchida, Sugino: The rasGAP-binding protein, Dok-1, mediates activin signaling via serine/threonine kinase receptors. in The EMBO journal 2002
Show all 5 references for ABIN392070
Human Polyclonal DOK1 Primary Antibody for IHC (p), WB - ABIN197042
Wick, Dong, Hu, Langlais, Liu: Insulin receptor-mediated p62dok tyrosine phosphorylation at residues 362 and 398 plays distinct roles for binding GTPase-activating protein and Nck and is essential for inhibiting insulin-stimulated activation of Ras and Akt. in The Journal of biological chemistry 2001
Show all 4 references for ABIN197042
Human Polyclonal DOK1 Primary Antibody for IF, IHC (p) - ABIN197538
Simoncic, Bourdeau, Lee-Loy, Rohrschneider, Tremblay, Stanley, McGlade: T-cell protein tyrosine phosphatase (Tcptp) is a negative regulator of colony-stimulating factor 1 signaling and macrophage differentiation. in Molecular and cellular biology 2006
Show all 4 references for ABIN197538
Human Polyclonal DOK1 Primary Antibody for IHC (p), WB - ABIN197536
Songyang, Yamanashi, Liu, Baltimore: Domain-dependent function of the rasGAP-binding protein p62Dok in cell signaling. in The Journal of biological chemistry 2001
Show all 3 references for ABIN197536
Human Polyclonal DOK1 Primary Antibody for WB - ABIN2792206
Zhao, Janas, Niki, Pandolfi, Van Aelst: Dok-1 independently attenuates Ras/mitogen-activated protein kinase and Src/c-myc pathways to inhibit platelet-derived growth factor-induced mitogenesis. in Molecular and cellular biology 2006
Show all 2 references for ABIN2792206
Human Polyclonal DOK1 Primary Antibody for IHC (p), WB - ABIN197040
Némorin, Duplay: Evidence that Llck-mediated phosphorylation of p56dok and p62dok may play a role in CD2 signaling. in The Journal of biological chemistry 2000
Show all 2 references for ABIN197040
Human Polyclonal DOK1 Primary Antibody for WB - ABIN515056
Barrett, Evans, Frolov, Britton, Pellet-Many, Yamaji, Mehta, Bandopadhyay, Li, Brandner, Zachary, Frankel: A crucial role for DOK1 in PDGF-BB-stimulated glioma cell invasion through p130Cas and Rap1 signalling. in Journal of cell science 2014
Dok1 knockdown attenuated TLR2 (show TLR2 Antibodies)-induced NF-kappaB (show NFKB1 Antibodies) activation and IL-6 (show IL6 Antibodies) production in microglia.
Triple Dok1 Doc2 (show DOC2A Antibodies) Doc3 knockout leads to spontaneous pulmonary inflammation with hallmarks of asthma.
Dok-1 overexpression promotes the generation of an innate-like CD8 (show CD8A Antibodies)(+) T-cell population that expresses Eomesodermin (show EOMES Antibodies).
Studies using SHIP-1 (show INPP5D Antibodies) shRNA, knockout mice and decoy inhibitors further indicate that CD4 (show CD4 Antibodies)-mediated inhibition of TCR-mediated T cell activation is SHIP-1 (show INPP5D Antibodies) and Dok-1/2 dependent, and involves SHIP-1 (show INPP5D Antibodies) hydrolysis of Phosphatidylinositol 3,4,5-trisphosophate
Dok-1 and Dok-2 deficiency induces osteopenia by activation of osteoclasts.
these findings indicate that Dok-1, Dok-2, and Dok-3 (show DOK3 Antibodies) cooperatively suppress aggressive HS
Role of Dok1 in RET (show RET Antibodies)-mediated signaling
crystal structure of the Dok1 phosphotyrosine binding domain alone and in complex with a phosphopeptide derived from RET receptor tyrosine kinase (show RET Antibodies)
DOK1 and DOK2 interact with the Tec protein tyrosine kinase.
X-ray crystallographic models of the PTB (show PTBP1 Antibodies) domain of mouse dok1 protein
DOK1 was identified as a prognostic factor for non-metastatic CRC (show CALR Antibodies), and, via its drugability by PPARgamma (show PPARG Antibodies)-agonist, may constitute a potential target for future cancer treatments.
DOK3 (show DOK3 Antibodies) expression was not altered much in HTLV-1-infected T cells.
Results indicate that hypermethylation of tumor suppressor protein (show TP53 Antibodies) RASSF1A (show RASSF1 Antibodies) and docking protein 1 (DOK1) contributes to hepatocarcinogenesis and is associated to clinicopathological characteristics.
Data show that residues Ser745 and Ser756 in the integrin beta2 tail, which are adjacent to the NxxF motif, are required for docking protein 1, docking protein 1, 62kDa (show GTF2H1 Antibodies) (downstream of tyrosine kinase 1) (Dok1) interaction.
results support a model in which Dok1 phosphorylation normally suppresses localized Ras pathway activity in Crk (show CRK Antibodies)-transformed cells via recruitment and/or activation of RasGAP (show RASA1 Antibodies)
Data implicate existence of alternate conformational states around the ligand binding pocket of the PTB (show PTBP1 Antibodies) domain of phosphoprotien Dok1 either in the native or in the near native conditions.
Deregulation of DOK1 gene expression by EBV and novel insights into the regulation of the DOK1 tumor suppressor in viral-related carcinogenesis.
point mutations in DOK1 and DOK2 genes are detected with low frequency in chronic myelomonocytic leukemia but may have consequences for the function of the DOK2 PTB (show PTBP1 Antibodies) domain
A crucial role for DOK1 in the regulation of PDGF-BB-mediated tumour cell motility through a p130Cas-Rap1 signalling pathway.
Taken together, these results reveal that Dok1 and Dok2 proteins are involved in an intrinsic negative feedback loop downstream of natural killer-cell-activating receptors in mouse and human.
The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Two transcript variants encoding different isoforms have been found for this gene.
ADP-ribosyltransferase C2 and C3 toxin-like 4
, NAD(P)(+)--arginine ADP-ribosyltransferase 4
, ecto-ADP-ribosyltransferase 4
, mono(ADP-ribosyl)transferase 4
, downstream of tyrosine kinase 1
, downstream of tyrosine kinase-1
, Downstream of tyrosine kinase 1
, docking protein 1
, docking protein 1 (downstream of tyrosine kinase 1)