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anti-Docking Protein 1, 62kDa (Downstream of tyrosine Kinase 1) (DOK1) Antibodies

The protein encoded by DOK1 is part of a signal transduction pathway downstream of receptor tyrosine kinases. Additionally we are shipping DOK1 Kits (11) and DOK1 Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DOK1 109978 Q9CRA0
DOK1 312477 Q4QQV2
DOK1 1796 Q99704
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Top anti-DOK1 Antibodies at antibodies-online.com

Showing 10 out of 213 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-DOK1 Antibody Titration: 0.2-1 ug/mlPositive Control... 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-DOK1 Pab (ABIN392070) in HL-60 cell lysa... Western blot analysis of DOK1 (arrow) using DOK1 Antibody (N-term) (AB... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB 0.1 mL Log in to see 6 to 8 Days
$308.00
Details
Human Rabbit Un-conjugated IF, IHC (p), WB 0.1 mL Log in to see 6 to 8 Days
$308.00
Details
Human Rabbit Un-conjugated IHC (p), WB 0.1 mL Log in to see 6 to 8 Days
$357.50
Details
Human Rabbit Un-conjugated IHC (p), WB 0.1 mL Log in to see 6 to 8 Days
$357.50
Details
Human Mouse Un-conjugated IF, IP, IHC, WB Western blot analysis for p62 [Dok]. Hs68 cell lysates (Human skin fib... 50 μg Log in to see 5 to 6 Days
$205.42
Details
Human Mouse Un-conjugated WB Western Blot analysis of DOK1 expression in transfected 293T cell line... DOK1 MaxPab polyclonal antibody. Western Blot analysis of DOK1 express... 50 μL Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from 293 cells, using p62 Dok (Phosp... 100 μg Log in to see 2 to 3 Days
$275.00
Details

DOK1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Mouse (Murine) , , , ,

Rat (Rattus) , , , ,

Human , , , ,
,

Top referenced anti-DOK1 Antibodies

  1. Human Monoclonal DOK1 Primary Antibody for IF, IP - ABIN968157 : Carpino, Wisniewski, Strife, Marshak, Kobayashi, Stillman, Clarkson: p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells. in Cell 1997 (PubMed)
    Show all 5 references for ABIN968157

  2. Human Polyclonal DOK1 Primary Antibody for EIA, IHC (p) - ABIN359958 : Liang, Wisniewski, Strife, Shivakrupa, Clarkson, Resh: Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling. in The Journal of biological chemistry 2002 (PubMed)
    Show all 5 references for ABIN359958

  3. Human Polyclonal DOK1 Primary Antibody for IHC (p), WB - ABIN392070 : Yamakawa, Tsuchida, Sugino: The rasGAP-binding protein, Dok-1, mediates activin signaling via serine/threonine kinase receptors. in The EMBO journal 2002 (PubMed)
    Show all 5 references for ABIN392070

  4. Human Polyclonal DOK1 Primary Antibody for IHC (p), WB - ABIN197042 : Wick, Dong, Hu, Langlais, Liu: Insulin receptor-mediated p62dok tyrosine phosphorylation at residues 362 and 398 plays distinct roles for binding GTPase-activating protein and Nck and is essential for inhibiting insulin-stimulated activation of Ras and Akt. in The Journal of biological chemistry 2001 (PubMed)
    Show all 4 references for ABIN197042

  5. Human Polyclonal DOK1 Primary Antibody for IF, IHC (p) - ABIN197538 : Simoncic, Bourdeau, Lee-Loy, Rohrschneider, Tremblay, Stanley, McGlade: T-cell protein tyrosine phosphatase (Tcptp) is a negative regulator of colony-stimulating factor 1 signaling and macrophage differentiation. in Molecular and cellular biology 2006 (PubMed)
    Show all 4 references for ABIN197538

  6. Human Polyclonal DOK1 Primary Antibody for IHC (p), WB - ABIN197536 : Songyang, Yamanashi, Liu, Baltimore: Domain-dependent function of the rasGAP-binding protein p62Dok in cell signaling. in The Journal of biological chemistry 2001 (PubMed)
    Show all 3 references for ABIN197536

  7. Human Polyclonal DOK1 Primary Antibody for WB - ABIN2792206 : Zhao, Janas, Niki, Pandolfi, Van Aelst: Dok-1 independently attenuates Ras/mitogen-activated protein kinase and Src/c-myc pathways to inhibit platelet-derived growth factor-induced mitogenesis. in Molecular and cellular biology 2006 (PubMed)
    Show all 2 references for ABIN2792206

  8. Human Polyclonal DOK1 Primary Antibody for IHC (p), WB - ABIN197040 : Némorin, Duplay: Evidence that Llck-mediated phosphorylation of p56dok and p62dok may play a role in CD2 signaling. in The Journal of biological chemistry 2000 (PubMed)
    Show all 2 references for ABIN197040

  9. Human Polyclonal DOK1 Primary Antibody for WB - ABIN515056 : Barrett, Evans, Frolov, Britton, Pellet-Many, Yamaji, Mehta, Bandopadhyay, Li, Brandner, Zachary, Frankel: A crucial role for DOK1 in PDGF-BB-stimulated glioma cell invasion through p130Cas and Rap1 signalling. in Journal of cell science 2014 (PubMed)

More Antibodies against DOK1 Interaction Partners

Mouse (Murine) Docking Protein 1, 62kDa (Downstream of tyrosine Kinase 1) (DOK1) interaction partners

  1. Dok1 knockdown attenuated TLR2 (show TLR2 Antibodies)-induced NF-kappaB (show NFKB1 Antibodies) activation and IL-6 (show IL6 Antibodies) production in microglia.

  2. Triple Dok1 Doc2 (show DOC2A Antibodies) Doc3 knockout leads to spontaneous pulmonary inflammation with hallmarks of asthma.

  3. Dok-1 overexpression promotes the generation of an innate-like CD8 (show CD8A Antibodies)(+) T-cell population that expresses Eomesodermin (show EOMES Antibodies).

  4. Studies using SHIP-1 (show INPP5D Antibodies) shRNA, knockout mice and decoy inhibitors further indicate that CD4 (show CD4 Antibodies)-mediated inhibition of TCR-mediated T cell activation is SHIP-1 (show INPP5D Antibodies) and Dok-1/2 dependent, and involves SHIP-1 (show INPP5D Antibodies) hydrolysis of Phosphatidylinositol 3,4,5-trisphosophate

  5. Dok-1 and Dok-2 deficiency induces osteopenia by activation of osteoclasts.

  6. these findings indicate that Dok-1, Dok-2, and Dok-3 (show DOK3 Antibodies) cooperatively suppress aggressive HS

  7. Role of Dok1 in RET (show RET Antibodies)-mediated signaling

  8. crystal structure of the Dok1 phosphotyrosine binding domain alone and in complex with a phosphopeptide derived from RET receptor tyrosine kinase (show RET Antibodies)

  9. DOK1 and DOK2 interact with the Tec protein tyrosine kinase.

  10. X-ray crystallographic models of the PTB (show PTBP1 Antibodies) domain of mouse dok1 protein

Human Docking Protein 1, 62kDa (Downstream of tyrosine Kinase 1) (DOK1) interaction partners

  1. Data show that residues Ser745 and Ser756 in the integrin beta2 tail, which are adjacent to the NxxF motif, are required for docking protein 1, docking protein 1, 62kDa (show GTF2H1 Antibodies) (downstream of tyrosine kinase 1) (Dok1) interaction.

  2. results support a model in which Dok1 phosphorylation normally suppresses localized Ras pathway activity in Crk (show CRK Antibodies)-transformed cells via recruitment and/or activation of RasGAP (show RASA1 Antibodies)

  3. Data implicate existence of alternate conformational states around the ligand binding pocket of the PTB (show PTBP1 Antibodies) domain of phosphoprotien Dok1 either in the native or in the near native conditions.

  4. Deregulation of DOK1 gene expression by EBV and novel insights into the regulation of the DOK1 tumor suppressor in viral-related carcinogenesis.

  5. point mutations in DOK1 and DOK2 genes are detected with low frequency in chronic myelomonocytic leukemia but may have consequences for the function of the DOK2 PTB (show PTBP1 Antibodies) domain

  6. A crucial role for DOK1 in the regulation of PDGF-BB-mediated tumour cell motility through a p130Cas-Rap1 signalling pathway.

  7. Taken together, these results reveal that Dok1 and Dok2 proteins are involved in an intrinsic negative feedback loop downstream of natural killer-cell-activating receptors in mouse and human.

  8. BRK has a role in targeting Dok1 for ubiquitin-mediated proteasomal degradation and in promoting cell proliferation and migration

  9. The unique N-terminal region of SRMS (show SRMS Antibodies) regulates enzymatic activity and phosphorylation of its novel substrate docking protein 1.

  10. DNA methylation (show HELLS Antibodies) of the DOK1 core promoter region found in head and neck cancer cell lines hampered the recruitment of E2F1 (show E2F1 Antibodies) to the DOK1 promoter and compromised DOK1 expression.

DOK1 Antigen Profile

Protein Summary

The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with DOK1

  • ADP-ribosyltransferase 4 (Art4) antibody
  • docking protein 1 (Dok1) antibody
  • docking protein 1, 62kDa (downstream of tyrosine kinase 1) (DOK1) antibody
  • 4432404K01Rik antibody
  • ARTC4 antibody
  • AW557123 antibody
  • DO antibody
  • Dok-1 antibody
  • DOK1 antibody
  • P62DOK antibody

Protein level used designations for DOK1

ADP-ribosyltransferase C2 and C3 toxin-like 4 , NAD(P)(+)--arginine ADP-ribosyltransferase 4 , ecto-ADP-ribosyltransferase 4 , mono(ADP-ribosyl)transferase 4 , downstream of tyrosine kinase 1 , p62(dok) , downstream of tyrosine kinase-1 , Downstream of tyrosine kinase 1 , docking protein 1 , docking protein 1 (downstream of tyrosine kinase 1) , pp62

GENE ID SPECIES
109978 Mus musculus
13448 Mus musculus
312477 Rattus norvegicus
1796 Homo sapiens
483100 Canis lupus familiaris
100233179 Sus scrofa
514962 Bos taurus
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