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Docking Protein 1, 62kDa (Downstream of tyrosine Kinase 1) Proteins (DOK1)

The protein encoded by DOK1 is part of a signal transduction pathway downstream of receptor tyrosine kinases. Additionally we are shipping DOK1 Antibodies (213) and DOK1 Kits (11) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DOK1 109978 Q9CRA0
DOK1 312477 Q4QQV2
DOK1 1796 Q99704
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Top DOK1 Proteins at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,356.83
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,366.00
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

DOK1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus)

Human , ,
, ,

More Proteins for Docking Protein 1, 62kDa (Downstream of tyrosine Kinase 1) (DOK1) Interaction Partners

Mouse (Murine) Docking Protein 1, 62kDa (Downstream of tyrosine Kinase 1) (DOK1) interaction partners

  1. Dok1 knockdown attenuated TLR2-induced NF-kappaB (show NFKB1 Proteins) activation and IL-6 (show IL6 Proteins) production in microglia.

  2. Triple Dok1 Doc2 (show DOC2A Proteins) Doc3 knockout leads to spontaneous pulmonary inflammation with hallmarks of asthma.

  3. Dok-1 overexpression promotes the generation of an innate-like CD8 (show CD8A Proteins)(+) T-cell population that expresses Eomesodermin (show EOMES Proteins).

  4. Studies using SHIP-1 (show INPP5D Proteins) shRNA, knockout mice and decoy inhibitors further indicate that CD4 (show CD4 Proteins)-mediated inhibition of TCR-mediated T cell activation is SHIP-1 (show INPP5D Proteins) and Dok-1/2 dependent, and involves SHIP-1 (show INPP5D Proteins) hydrolysis of Phosphatidylinositol 3,4,5-trisphosophate

  5. Dok-1 and Dok-2 deficiency induces osteopenia by activation of osteoclasts.

  6. these findings indicate that Dok-1, Dok-2, and Dok-3 (show DOK3 Proteins) cooperatively suppress aggressive HS

  7. Role of Dok1 in RET (show RET Proteins)-mediated signaling

  8. crystal structure of the Dok1 phosphotyrosine binding domain alone and in complex with a phosphopeptide derived from RET receptor tyrosine kinase (show RET Proteins)

  9. DOK1 and DOK2 interact with the Tec protein tyrosine kinase.

  10. X-ray crystallographic models of the PTB (show PTBP1 Proteins) domain of mouse dok1 protein

Human Docking Protein 1, 62kDa (Downstream of tyrosine Kinase 1) (DOK1) interaction partners

  1. DOK3 (show DOK3 Proteins) expression was not altered much in HTLV-1-infected T cells.

  2. Results indicate that hypermethylation of tumor suppressor protein (show TP53 Proteins) RASSF1A (show RASSF1 Proteins) and docking protein 1 (DOK1) contributes to hepatocarcinogenesis and is associated to clinicopathological characteristics.

  3. Data show that residues Ser745 and Ser756 in the integrin beta2 tail, which are adjacent to the NxxF motif, are required for docking protein 1, docking protein 1, 62kDa (show GTF2H1 Proteins) (downstream of tyrosine kinase 1) (Dok1) interaction.

  4. results support a model in which Dok1 phosphorylation normally suppresses localized Ras pathway activity in Crk (show CRK Proteins)-transformed cells via recruitment and/or activation of RasGAP (show RASA1 Proteins)

  5. Data implicate existence of alternate conformational states around the ligand binding pocket of the PTB (show PTBP1 Proteins) domain of phosphoprotien Dok1 either in the native or in the near native conditions.

  6. Deregulation of DOK1 gene expression by EBV and novel insights into the regulation of the DOK1 tumor suppressor in viral-related carcinogenesis.

  7. point mutations in DOK1 and DOK2 genes are detected with low frequency in chronic myelomonocytic leukemia but may have consequences for the function of the DOK2 PTB (show PTBP1 Proteins) domain

  8. A crucial role for DOK1 in the regulation of PDGF-BB-mediated tumour cell motility through a p130Cas-Rap1 signalling pathway.

  9. Taken together, these results reveal that Dok1 and Dok2 proteins are involved in an intrinsic negative feedback loop downstream of natural killer-cell-activating receptors in mouse and human.

  10. BRK has a role in targeting Dok1 for ubiquitin-mediated proteasomal degradation and in promoting cell proliferation and migration

DOK1 Protein Profile

Protein Summary

The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with DOK1

  • ADP-ribosyltransferase 4 (Art4)
  • docking protein 1 (Dok1)
  • docking protein 1, 62kDa (downstream of tyrosine kinase 1) (DOK1)
  • 4432404K01Rik protein
  • ARTC4 protein
  • AW557123 protein
  • DO protein
  • Dok-1 protein
  • DOK1 protein
  • P62DOK protein

Protein level used designations for DOK1

ADP-ribosyltransferase C2 and C3 toxin-like 4 , NAD(P)(+)--arginine ADP-ribosyltransferase 4 , ecto-ADP-ribosyltransferase 4 , mono(ADP-ribosyl)transferase 4 , downstream of tyrosine kinase 1 , p62(dok) , downstream of tyrosine kinase-1 , Downstream of tyrosine kinase 1 , docking protein 1 , docking protein 1 (downstream of tyrosine kinase 1) , pp62

GENE ID SPECIES
109978 Mus musculus
13448 Mus musculus
312477 Rattus norvegicus
1796 Homo sapiens
483100 Canis lupus familiaris
100233179 Sus scrofa
514962 Bos taurus
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