Docking Protein 1, 62kDa (Downstream of tyrosine Kinase 1) Proteins (DOK1)

The protein encoded by DOK1 is part of a signal transduction pathway downstream of receptor tyrosine kinases. Additionally we are shipping DOK1 Antibodies (220) and DOK1 Kits (11) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DOK1 109978 Q9CRA0
DOK1 312477 Q4QQV2
DOK1 1796 Q99704
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Top DOK1 Proteins at antibodies-online.com

Showing 8 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag   50 μg Log in to see 11 Days
$341.00
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,356.83
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$3,366.00
Details
HOST_Escherichia coli (E. coli) Rat T7 tag,His tag   100 μg Log in to see 15 to 18 Days
$688.00
Details

DOK1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus) ,
,
Human , , ,
, , ,

More Proteins for Docking Protein 1, 62kDa (Downstream of tyrosine Kinase 1) (DOK1) Interaction Partners

Mouse (Murine) Docking Protein 1, 62kDa (Downstream of tyrosine Kinase 1) (DOK1) interaction partners

  1. These results reveal the critical involvement of Dok-1 and Dok-2 in a negative-feedback loop that prevents overactivation of CD8 (show CD8A Proteins)(+) T cells and promotes memory formation.

  2. Thus, Dok-1 and Dok-2 promote survival of glycoprotein B-specific CD8 (show CD8A Proteins)(+) T cells in trigeminal ganglia latently infected with herpes simplex virus 1.

  3. this study shows that Dok1 and Dok2 proteins are involved in the control of hematopoietic stem cell cycle regulation

  4. Taken together, our results demonstrate that Dok-1 and Dok-2 negatively regulate intestinal inflammation, apparently through the induction of IL-17A (show IL17A Proteins) and IL-22 (show IL22 Proteins) expression.

  5. Dok1 knockdown attenuated TLR2-induced NF-kappaB (show NFKB1 Proteins) activation and IL-6 (show IL6 Proteins) production in microglia.

  6. Triple Dok1 Doc2 (show DOC2A Proteins) Doc3 knockout leads to spontaneous pulmonary inflammation with hallmarks of asthma.

  7. Dok-1 overexpression promotes the generation of an innate-like CD8 (show CD8A Proteins)(+) T-cell population that expresses Eomesodermin (show EOMES Proteins).

  8. Studies using SHIP-1 (show INPP5D Proteins) shRNA, knockout mice and decoy inhibitors further indicate that CD4 (show CD4 Proteins)-mediated inhibition of TCR-mediated T cell activation is SHIP-1 (show INPP5D Proteins) and Dok-1/2 dependent, and involves SHIP-1 (show INPP5D Proteins) hydrolysis of Phosphatidylinositol 3,4,5-trisphosophate

  9. Dok-1 and Dok-2 deficiency induces osteopenia by activation of osteoclasts.

  10. these findings indicate that Dok-1, Dok-2, and Dok-3 (show DOK3 Proteins) cooperatively suppress aggressive HS

Human Docking Protein 1, 62kDa (Downstream of tyrosine Kinase 1) (DOK1) interaction partners

  1. Taken together, these results indicate that ATRA-enhanced expression of DOK1 activates PPARgamma (show PPARG Proteins) leading to inhibition of cell proliferation and enhancement of cell apoptosis in MCF-7 cell.

  2. DOK1 was identified as a prognostic factor for non-metastatic CRC (show CALR Proteins), and, via its drugability by PPARgamma (show PPARG Proteins)-agonist, may constitute a potential target for future cancer treatments.

  3. DOK3 (show DOK3 Proteins) expression was not altered much in HTLV-1-infected T cells.

  4. Results indicate that hypermethylation of tumor suppressor protein (show TP53 Proteins) RASSF1A (show RASSF1 Proteins) and docking protein 1 (DOK1) contributes to hepatocarcinogenesis and is associated to clinicopathological characteristics.

  5. Data show that residues Ser745 and Ser756 in the integrin beta2 tail, which are adjacent to the NxxF motif, are required for docking protein 1, docking protein 1, 62kDa (show GTF2H1 Proteins) (downstream of tyrosine kinase 1) (Dok1) interaction.

  6. results support a model in which Dok1 phosphorylation normally suppresses localized Ras pathway activity in Crk (show CRK Proteins)-transformed cells via recruitment and/or activation of RasGAP (show RASA1 Proteins)

  7. Data implicate existence of alternate conformational states around the ligand binding pocket of the PTB (show PTBP1 Proteins) domain of phosphoprotien Dok1 either in the native or in the near native conditions.

  8. Deregulation of DOK1 gene expression by EBV and novel insights into the regulation of the DOK1 tumor suppressor in viral-related carcinogenesis.

  9. point mutations in DOK1 and DOK2 genes are detected with low frequency in chronic myelomonocytic leukemia but may have consequences for the function of the DOK2 PTB (show PTBP1 Proteins) domain

  10. A crucial role for DOK1 in the regulation of PDGF-BB-mediated tumour cell motility through a p130Cas-Rap1 signalling pathway.

DOK1 Protein Profile

Protein Summary

The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with DOK1

  • ADP-ribosyltransferase 4 (Art4)
  • docking protein 1 (Dok1)
  • docking protein 1, 62kDa (downstream of tyrosine kinase 1) (DOK1)
  • 4432404K01Rik protein
  • ARTC4 protein
  • AW557123 protein
  • DO protein
  • Dok-1 protein
  • DOK1 protein
  • P62DOK protein

Protein level used designations for DOK1

ADP-ribosyltransferase C2 and C3 toxin-like 4 , NAD(P)(+)--arginine ADP-ribosyltransferase 4 , ecto-ADP-ribosyltransferase 4 , mono(ADP-ribosyl)transferase 4 , downstream of tyrosine kinase 1 , p62(dok) , downstream of tyrosine kinase-1 , Downstream of tyrosine kinase 1 , docking protein 1 , docking protein 1 (downstream of tyrosine kinase 1) , pp62

GENE ID SPECIES
109978 Mus musculus
13448 Mus musculus
312477 Rattus norvegicus
1796 Homo sapiens
483100 Canis lupus familiaris
100233179 Sus scrofa
514962 Bos taurus
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