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DOK proteins are enzymatically inert adaptor or scaffolding proteins. Additionally we are shipping DOK3 Proteins (8) and many more products for this protein.
Showing 10 out of 95 products:
Human Polyclonal DOK3 Primary Antibody for EIA, IHC (p) - ABIN951967
Berger, Niki, Morotti, Taylor, Socci, Viale, Brennan, Szoke, Motoi, Rothman, Teruya-Feldstein, Gerald, Ladanyi, Pandolfi: Identification of DOK genes as lung tumor suppressors. in Nature genetics 2010
Show all 5 references for ABIN951967
Cow (Bovine) Polyclonal DOK3 Primary Antibody for WB - ABIN374125
Heckel, Czupalla, Expirto Santo, Anitei, Arantzazu Sanchez-Fernandez, Mosch, Krause, Hoflack: Src-dependent repression of ARF6 is required to maintain podosome-rich sealing zones in bone-digesting osteoclasts. in Proceedings of the National Academy of Sciences of the United States of America 2009
Human Polyclonal DOK3 Primary Antibody for ELISA, WB - ABIN184642
Lemay, Davidson, Latour, Veillette: Dok-3, a novel adapter molecule involved in the negative regulation of immunoreceptor signaling. in Molecular and cellular biology 2000
Mutations in DOK3 gene is associated with prostate cancer
DOK2 and DOK3 expression was significantly reduced in HTLV-1-infected T cells.
The Dok-3/Grb2 (show GRB2 Antibodies) protein signal module attenuates Lyn (show LYN Antibodies) kinase-dependent activation of Syk (show SYK Antibodies) kinase in B cell antigen receptor microclusters
absence of DOK3 increases LPS (show IRF6 Antibodies) signaling, contributing to LPS (show IRF6 Antibodies)-induced tolerance. Thus, DOK3 plays a role in TLR signaling during both naive and endotoxin-induced tolerant conditions
The novel platelet adapter Dok-3 is tyrosine phosphorylated in an Src kinase (show CSK Antibodies)-independent manner downstream of alphaIIbbeta3 in human platelets, leading to an interaction with Grb2 (show GRB2 Antibodies) and SHIP-1 (show INPP5D Antibodies).
findings indicate that Dok-3 sequesters Grb2 (show GRB2 Antibodies) from Shc (show SHC1 Antibodies) and inhibits the Ras-Erk (show EPHB2 Antibodies) pathway downstream of PTKs
we demonstrate that CpG treatment leads to ubiquitin-mediated degradation of DOK3 via interaction with an E3 ligase TNFR (show TNFRSF1A Antibodies)-associated factor 6 (TRAF6 (show TRAF6 Antibodies)).
This study reveals DOK3 as a nonredundant regulator of plasma cell differentiation by up-regulating PD-1 (show PDCD1 Antibodies) ligand expression through the attenuation of calcium signaling.
Data show that docking protein 3 (DOK3) plays a role in TLR3 (show TLR3 Antibodies) signaling by enabling TNFR (show TNFRSF1A Antibodies)-associated factor (TRAF) 3 (show TRAF3 Antibodies)/TANK-binding kinase (TBK) 1 (show TBK1 Antibodies) binding and facilitating TBK1 (show TBK1 Antibodies) and IFN regulatory factor 3 activation and the induction of IFN-beta (show IFNB1 Antibodies) production.
DOK3 physically associated with the ITAM of DAP12 (show TYROBP Antibodies) through its phosphotyrosine-binding domain. In response to LPS (show TLR4 Antibodies), DOK3 was phosphorylated in a DAP12 (show TYROBP Antibodies)- and Src (show SRC Antibodies)-dependent manner, which led to translocation of phosphorylated DOK3 to the plasma membrane.
Triple Dok1 (show DOK1 Antibodies) Doc2 (show DOC2A Antibodies) Doc3 knockout leads to spontaneous pulmonary inflammation with hallmarks of asthma.
absence of DOK3 increases LPS (show TLR4 Antibodies) signaling, contributing to LPS (show TLR4 Antibodies)-induced tolerance. Thus, DOK3 plays a role in TLR signaling during both naive and endotoxin-induced tolerant conditions
identify a surprising but pivotal role for dynein and the microtubule network alongside Grb2 (show GRB2 Antibodies), Dok-3, and Cbl (show CBL Antibodies) in antigen gathering during B cell activation (show BLNK Antibodies)
Subcellular localization of Grb2 (show GRB2 Antibodies) by the adaptor protein Dok-3 restricts the intensity of Ca2 (show CA2 Antibodies)+ signaling in B cells.
In the absence of Dok-3, the localization of the inhibitory phosphatase SHIP-1 (show INPP5D Antibodies) to the plasma membrane is intact while its phosphorylation is compromised, suggesting that Dok-3 could function to facilitate or sustain the activation of SHIP-1 (show INPP5D Antibodies).
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. Plays a role as negative regulator of the mobilization of calcium ions and of calcium signaling.
docking protein 3
, Dok-like protein
, downstream of tyrosine kinase 3
, p62(dok)-like protein
, p62Dok-like protein
, Downstream of tyrosine kinase 3