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The protein encoded by DMRT2 belongs to the DMRT gene family, sharing a DM DNA-binding domain with Drosophila 'doublesex' (dsx) and C. Additionally we are shipping DMRT2 Antibodies (11) and many more products for this protein.
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Celf1 (show CELF1 Proteins)-dependent fine-tuning of dmrt2a expression is essential for generating bilateral symmetry of somites and left-right asymmetric patterning during zebrafish development.
the role of dmrt2 gene is not conserved during zebrafish and mouse embryonic development
These results reveal a novel genetic network, comprising a Pax3 (show PAX3 Proteins)/Dmrt2/Myf5 (show MYF5 Proteins) regulatory cascade that operates in stem cells of the epaxial dermomyotome to initiate skeletal muscle formation.
Dmrt2 is involved in somite development and provide evidence that DM domain genes have been co-opted into other critical developmental pathways distinct from that of sex determination or differentiation.
Dmrt2 is associated with embryonic myogensis.
The protein encoded by this gene belongs to the DMRT gene family, sharing a DM DNA-binding domain with Drosophila 'doublesex' (dsx) and C. elegans mab3, genes involved in sex determination in these organisms. Also, this gene is located in a region of the human genome (chromosome 9p24.3) associated with gonadal dysgenesis and XY sex reversal. Hence this gene is one of the candidates for sex-determining gene(s) on chr 9.
doublesex and mab-3 related transcription factor 2
, doublesex- and mab-3-related transcription factor 2
, DM domain-containing transcription factor DMRT2
, doublesex-like 2 protein
, terra-like protein
, terra homolog