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Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity (By similarity). Additionally we are shipping DUSP26 Proteins (7) and many more products for this protein.
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Human Polyclonal DUSP26 Primary Antibody for ICC, IF - ABIN441285
Shi, Ma, Patel, Shang, Chen, Zhao, Cheng, Fan, Rojas, Barbieri, Chen, Yu, Jin, Kim, Shohet, Vasudevan, Yang: NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis. in Cell death & disease 2015
results suggest that AK2 (show AK2 Antibodies) is an associated activator of DUSP26 and suppresses cell proliferation by FADD (show FADD Antibodies) dephosphorylation, postulating AK2 (show AK2 Antibodies) as a negative regulator of tumour growth.
The study reports the 1.68 A crystal structure of a catalytically inactive mutant (Cys152Ser) of DUSP26 lacking the first 60 N-terminal residues (DeltaN60-C/S-DUSP26).
DUSP26 may function as a tumour suppressor in particular cancers.
DUSP26 functions as a p53 (show TP53 Antibodies) phosphatase
DUSP26 effectively dephosphorylates p38 (show CRK Antibodies) and has a little effect on extracellular signal-regulated kinase in anaplastic thyroid cancer.
Downregulation of Dusp26 may contribute to malignant phenotypes of glioma.
DUSP26 down-regulation is an effective antineoplastic neuroblastoma (show ARHGEF16 Antibodies) strategy through activation of the p53 (show TP53 Antibodies) and p38 MAPK (show MAPK14 Antibodies) tumor-suppressor pathways.
Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity (By similarity).
, MAP kinase phosphatase 8
, Novel amplified gene in thyroid anaplastic cancer
, dual specificity phosphatase SKRP3
, dual specificity protein phosphatase 26
, dual-specificity phosphatase SKRP3
, low-molecular-mass dual-specificity phosphatase 4
, mitogen-activated protein kinase phosphatase 8