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Duffy Blood Group, Chemokine Receptor Proteins (DARC)

The protein encoded by DARC is a glycosylated membrane protein and a non-specific receptor for several chemokines. Additionally we are shipping DARC Antibodies (97) and DARC Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DARC 2532 Q16570
Rat DARC DARC 689105  
DARC 13349 Q9QUI6
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Top DARC Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag,GST tag 100 μg Log in to see 11 to 13 Days
$792.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 9 to 11 Days
$451.00
Details
HOST_Wheat germ Human Un-conjugated   2 μg Log in to see 9 Days
$491.43
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 19 Days
$967.75
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

DARC Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Duffy Blood Group, Chemokine Receptor (DARC) Interaction Partners

Human Duffy Blood Group, Chemokine Receptor (DARC) interaction partners

  1. We showed that DARC expression is down-regulated in CRC (show CALR Proteins) and associated with clinical pathological features and MVD (show MVD Proteins) of CRC (show CALR Proteins). DARC might be involved in tumorigenesis, progression, angiogenesis, and metastasis of CRC (show CALR Proteins).

  2. DARC is required for Staphylococcus aureus-mediated lysis of human erythrocytes, and DARC overexpression is sufficient to render cells susceptible to toxin-mediated lysis.

  3. study demonstrates the association of SNP rs12075 from DARC gene with the levels of serum IL8 (show IL8 Proteins)

  4. DARC levels are elevated in human keloid fibroblasts and might inhibit the secretion of CCL2 (show CCL2 Proteins).

  5. Through molecular genotyping we also identified polymorphisms in RhCE, Kell, Duffy, Colton, Lutheran and Scianna loci in donors and patients.

  6. Duffy blood group

  7. Isothermal titration calorimetry studies show these structures are part of a multi-step binding pathway, and individual point mutations of residues contacting DARC result in a complete loss of RBC (show CACNA1C Proteins) binding by DBP (show GC Proteins)-RII.

  8. DARC polymorphisms may influence the naturally acquired inhibitory anti-Duffy binding protein II (show ANXA4 Proteins) immunity

  9. DARC facilitates CXCL1 inhibition of airway smooth muscle cell migration via modulation of the ERK-1 (show MAPK3 Proteins)/2 MAP kinase (show MAPK1 Proteins) signaling pathway.

  10. DARC antigen is associated with a likelihood for patients to develop leg ulcers in sickle cell disease.

Mouse (Murine) Duffy Blood Group, Chemokine Receptor (DARC) interaction partners

  1. Ackr1 deficiency appears to be protective in the ApoE (show APOE Proteins) knockout model of atherogenesis, but it is associated with only modest changes in cytokine and chemokine (show CCL1 Proteins) expression as well as T-cell subset frequency and inflammatory macrophage content.

  2. Darc plays a role in modulating the regulation of inflammatory response to bone injury and that lack of Darc expression promotes cartilage formation in fracture calluses but does not affect bony union or fracture healing at 21 days post-fracture.

  3. The data showed a role for erythrocyte DARC as a chemokine (show CCL1 Proteins) reservoir and that endothelial DARC contributes to the pathogenesis of experimental autoimmune encephalomyelitis by shuttling chemokines across the blood-brain barrier.

  4. DARC is crucial for chemokine (show CCL1 Proteins)-mediated leukocyte recruitment in vivo.

  5. Plasmodium yoelii uses the murine Duffy antigen receptor for chemokines as a receptor for normocyte invasion and an alternative receptor for reticulocyte invasion.

  6. Vascular endothelial cells may induce Duffy protein to regulate leukocytes and/or chemokine (show CCL1 Proteins) trafficking

  7. role of the Duffy antigen and glycophorin A (show GYPA Proteins) as receptors for rodent malaria parasite invasion of erythrocytes

  8. DARC functions to clear angiogenic CXC chemokines from the prostate tumor microcirculation

  9. Darc regulates bone mineral density (BMD (show BEST1 Proteins))negatively by increasing osteoclast formation. Darc is proposed as a candidate gene for chromosome 1 BMD (show BEST1 Proteins) QTL2.

  10. Loss of red cell chemokine (show CCL1 Proteins) scavenging promotes transfusion-related lung inflammation

Cow (Bovine) Duffy Blood Group, Chemokine Receptor (DARC) interaction partners

  1. the 5' flanking region of the DARC gene was isolated and characterized

DARC Protein Profile

Protein Summary

The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines. The encoded protein is the receptor for the human malarial parasites Plasmodium vivax and Plasmodium knowlesi. Polymorphisms in this gene are the basis of the Duffy blood group system. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with DARC

  • Duffy blood group, chemokine receptor (DARC)
  • Duffy blood group, atypical chemokine receptor (DARC)
  • Duffy blood group, atypical chemokine receptor (Darc)
  • Duffy blood group, chemokine receptor (Darc)
  • AA162249 protein
  • Ackr1 protein
  • CCBP1 protein
  • CD234 protein
  • DARC protein
  • Dfy protein
  • ESTM35 protein
  • FY protein
  • GPD protein
  • GpFy protein
  • WBCQ1 protein

Protein level used designations for DARC

Duffy blood group, chemokine receptor , duffy antigen/chemokine receptor , Duffy antigen/chemokine receptor , Duffy blood group antigen , Fy glycoprotein , atypical chemokine receptor 1 , glycoprotein D , plasmodium vivax receptor , Duffy antigen receptor for chemokines , blood group antigen , duffy antigen/receptor for chemokine glycoprotein

GENE ID SPECIES
396618 Sus scrofa
478969 Canis lupus familiaris
100398804 Callithrix jacchus
100458473 Pongo abelii
100500770 Papio anubis
2532 Homo sapiens
689105 Rattus norvegicus
13349 Mus musculus
528076 Bos taurus
745985 Pan troglodytes
719284 Macaca mulatta
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