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E2F Transcription Factor 8 Proteins (E2F8)

E2F8 encodes a member of a family of transcription factors which regulate the expression of genes required for progression through the cell cycle. Additionally we are shipping E2F8 Antibodies (40) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
E2F8 79733 A0AVK6
Rat E2F8 E2F8 308607  
E2F8 108961 Q58FA4
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Top E2F8 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

E2F8 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for E2F Transcription Factor 8 (E2F8) Interaction Partners

Human E2F Transcription Factor 8 (E2F8) interaction partners

  1. transcription factor E2F8 is involved in the polyploidization during mouse and human decidualization

  2. E2F8 is overexpressed in Lung Cancer and is required for the growth of LC cells. E2F8 knockdown reduced the expression of UHRF1 (show UHRF1 Proteins). These findings implicate E2F8 as a novel therapeutic target for LC treatment.

  3. The results identify E2F8 as a repressor and E2F1 (show E2F1 Proteins) as an activator of a transcriptional network controlling polyploidization in mammalian cells.

  4. Analyses indicated that E2F8 could bind to regulatory elements of cyclin D1 (show CCND1 Proteins), regulating its transcription and promoting accumulation of S-phase cells. Findings suggest that E2F8 contributes to the oncogenic potential of HCC (show FAM126A Proteins)

  5. The similarities between E2F-7 (show E2F7 Proteins) and E2F-8 define a new subgroup of the E2F (show E2F1 Proteins) family, and further imply that E2F-7 (show E2F7 Proteins) and E2F-8 may act through overlapping mechanisms in mediating cell cycle control.

  6. E2F8 may have an important role in repressing the expression of E2F (show E2F1 Proteins)-target genes in the S-phase of the cell cycle.

  7. E2F7 (show E2F7 Proteins) and E2F8 act upstream of E2F1 (show E2F1 Proteins), and influence the ability of cells to undergo a DNA-damage response.

Mouse (Murine) E2F Transcription Factor 8 (E2F8) interaction partners

  1. transcription factor E2F8 is involved in the polyploidization during mouse and human decidualization

  2. Rb and E2F8 collaborate to promote DNA replication.

  3. The results identify E2F8 as a repressor and E2F1 (show E2F1 Proteins) as an activator of a transcriptional network controlling polyploidization in mammalian cells.

  4. The specificity of E2F8 in mediating Rb function in erythropoiesis suggests a critical and overlapping roles of Rb and E2f8 in maintaining normal erythropoiesis and in preventing hemolysis.

  5. Overexpression of E2F8 significantly slows down the proliferation of primary mouse embryonic fibroblasts.

  6. E2F8 may have an important role in repressing the expression of E2F (show E2F1 Proteins)-target genes in the S-phase of the cell cycle.

  7. Results identify E2F7 (show E2F7 Proteins) and E2F8 as a unique repressive arm of the E2F (show E2F1 Proteins) transcriptional network that is critical for embryonic development.

E2F8 Protein Profile

Protein Summary

This gene encodes a member of a family of transcription factors which regulate the expression of genes required for progression through the cell cycle. The encoded protein regulates progression from G1 to S phase by ensuring the nucleus divides at the proper time. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Gene names and symbols associated with E2F8

  • E2F transcription factor 8 (E2F8)
  • E2F transcription factor 8 (e2f8)
  • E2F transcription factor 8 (E2f8)
  • 4432406C08Rik protein
  • AA410048 protein
  • E2F-8 protein
  • E2F8 protein
  • MGC130750 protein
  • RGD1308091 protein

Protein level used designations for E2F8

E2F transcription factor 8 , E2F family member 8 , transcription factor E2F8 , transcription factor E2F8-like , E2F-8 , E2f family member 8

GENE ID SPECIES
100071962 Equus caballus
431926 Xenopus laevis
451072 Pan troglodytes
476885 Canis lupus familiaris
702368 Macaca mulatta
786629 Bos taurus
100022016 Monodelphis domestica
100142691 Xenopus (Silurana) tropicalis
100350717 Oryctolagus cuniculus
100408568 Callithrix jacchus
100433444 Pongo abelii
100582756 Nomascus leucogenys
79733 Homo sapiens
308607 Rattus norvegicus
108961 Mus musculus
422978 Gallus gallus
100522785 Sus scrofa
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