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SIAH1 encodes a protein that is a member of the seven in absentia homolog (SIAH) family. Additionally we are shipping SIAH1 Antibodies (90) and SIAH1 Proteins (9) and many more products for this protein.
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SIAH1 is associated with a tumor promoting role in breast cancer.
In neuroblastoma cells, siRNA silencing of SIAH1 promoted cellular proliferation and suppressed apoptosis. Protein and mRNA expression of alpha-synuclein, LC3-II and p53 decreased after SIAH1 knockdown. E1 protein and mRNA levels increased after SIAH1 siRNA.
Results demonstrated that miR-107 directly down-regulated SIAH1 expression in human breast cancer cells. An inverse correlation between the expression of miR-107 and SIAH1 was found in human breast cancer tissues and cell lines.
Similar to TAp73, DNp73 is stabilized by hypoxia in a HIF-1a-dependent manner, which otherwise is degraded by Siah1.
findings demonstrate that dissociation of the GAPDH/Siah1 pro-apoptotic complex can block high glucose-induced pericyte apoptosis, widely considered a hallmark feature of DR
Data indicate that ubiquitin ligase Siah as a regulator of to Mesenchymal Transition (EMT (show ITK ELISA Kits)) by controlling the abundance of the key transcription factor Zeb1 (show ZEB1 ELISA Kits), while Siah itself is subject to regulation by EMT (show ITK ELISA Kits)-inducing factors.
miRNA network regulates SIAH1 in in colorectal metastasis tissues.
CDK2 up-regulates the protein level of KLF10 through reducing its association with SIAH1, a KLF10 E3-ubiqutin ligase involved in proteasomal degradation.
molecular basis of Siah1 and Siah2 E3 ubiquitin ligase substrate specificity
Siah1 is a substrate of ASK1 for activation of the GAPDH-Siah1 oxidative stress signaling cascade.
two splicing forms, Siah1a and Siah1b, of the Xenopus seven in absentia homolog 1 gene (Siah1) were characterized.
This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
E3 ubiquitin-protein ligase Siah1
, E3 ubiquitin-protein ligase SIAH1
, seven in absentia homolog 1
, seven in absentia 1A
, seven in absentia-like protein 1