E3 Ubiquitin-Protein Ligase SIAH1 Proteins (SIAH1)

SIAH1 encodes a protein that is a member of the seven in absentia homolog (SIAH) family. Additionally we are shipping SIAH1 Antibodies (102) and SIAH1 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SIAH1 140941 Q920M9
SIAH1 6477 Q8IUQ4
SIAH1 177138 Q965X6
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Top SIAH1 Proteins at antibodies-online.com

Showing 8 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 15 to 19 Days
$407.00
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,740.83
Details
Yeast Zebrafish His tag   1 mg Log in to see 60 to 71 Days
$2,740.83
Details
Yeast Caenorhabditis elegans His tag   1 mg Log in to see 60 to 71 Days
$3,166.17
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 2 to 3 Days
$498.21
Details

SIAH1 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Human , ,
,
Caenorhabditis elegans (C. elegans)

Top referenced SIAH1 Proteins

  1. Human SIAH1 Protein expressed in Escherichia coli (E. coli) - ABIN1098362 : Hu, Fearon: Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins. in Molecular and cellular biology 1999 (PubMed)
    Show all 2 references for 1098362

More Proteins for E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1) Interaction Partners

Human E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1) interaction partners

  1. Study identified SIAH1/2 (SIAH) as the E3 ligase mediating Wnt (show WNT2 Proteins)-induced Axin (show AXIN1 Proteins) degradation. SIAH proteins promote the ubiquitination and proteasomal degradation of Axin (show AXIN1 Proteins) through interacting with a VxP motif in the GSK3-binding domain of Axin (show AXIN1 Proteins), and this function of SIAH is counteracted by GSK3 binding to Axin (show AXIN1 Proteins).

  2. results suggest that CacyBP/SIP (show CACYBP Proteins) is involved in regulation of the Hsp90 chaperone (show HSP90 Proteins) machinery

  3. PINK1 (show PINK1 Proteins) disease mutants failed to recruit synphilin-1 (show SNCAIP Proteins) and did not activate mitophagy, indicating that PINK1 (show PINK1 Proteins)-synphilin-1 (show SNCAIP Proteins)-SIAH-1 represents a new parkin (show PARK2 Proteins)-independent mitophagy pathway. Drugs that activate this pathway will provide a novel strategy to promote the clearance of damaged mitochondria in Parkinson's disease.

  4. Results suggest that activated STAT3 (show STAT3 Proteins) regulates active beta-catenin (show CTNNB1 Proteins) protein levels via stabilization of SIAH-1 and the subsequent ubiquitin-dependent proteasomal degradation of beta-catenin (show CTNNB1 Proteins) in HEK293T cells.

  5. Siah-1 expression was observed in 41.4% of oral squamous cell carcinoma. Siah-1 was expressed in the cytoplasm and cell membranes, and partially in the nucleus .

  6. SIAH1 is associated with a tumor promoting role in breast cancer.

  7. In neuroblastoma cells, siRNA silencing of SIAH1 promoted cellular proliferation and suppressed apoptosis. Protein and mRNA expression of alpha-synuclein, LC3-II and p53 decreased after SIAH1 knockdown. E1 protein and mRNA levels increased after SIAH1 siRNA.

  8. Results demonstrated that miR-107 directly down-regulated SIAH1 expression in human breast cancer cells. An inverse correlation between the expression of miR-107 and SIAH1 was found in human breast cancer tissues and cell lines.

  9. Similar to TAp73, DNp73 is stabilized by hypoxia in a HIF-1a-dependent manner, which otherwise is degraded by Siah1.

  10. findings demonstrate that dissociation of the GAPDH/Siah1 pro-apoptotic complex can block high glucose-induced pericyte apoptosis, widely considered a hallmark feature of DR

Xenopus laevis E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1) interaction partners

  1. two splicing forms, Siah1a and Siah1b, of the Xenopus seven in absentia homolog 1 gene (Siah1) were characterized.

SIAH1 Protein Profile

Protein Summary

This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

Gene names and symbols associated with SIAH1

  • E3 ubiquitin-protein ligase Siah1 (Tsp_03055)
  • Protein SIAH-1 (siah-1)
  • seven in absentia 1A (Siah1a)
  • seven in absentia homolog 1 (Drosophila) (siah1)
  • seven in absentia homolog 1 (Drosophila) (SIAH1)
  • siah E3 ubiquitin protein ligase 1 (SIAH1)
  • siah E3 ubiquitin protein ligase 1 (siah1)
  • id:ibd2635 protein
  • siah protein
  • Siah1 protein
  • SIAH1A protein
  • zgc:56026 protein

Protein level used designations for SIAH1

E3 ubiquitin-protein ligase Siah1 , E3 ubiquitin-protein ligase SIAH1 , seven in absentia homolog 1 , siah-1 , siah-1a , seven in absentia 1A , seven in absentia-like protein 1

GENE ID SPECIES
10900332 Trichinella spiralis
177138 Caenorhabditis elegans
140941 Rattus norvegicus
80955 Danio rerio
534655 Bos taurus
374076 Gallus gallus
6477 Homo sapiens
443864 Xenopus laevis
487293 Canis lupus familiaris
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