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The zinc finger protein encoded by E4F1 is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. Additionally we are shipping E4F1 Antibodies (18) and many more products for this protein.
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Whole exome sequencing has unraveled the presence of pathogenic mutations in genes encoding non-mitochondrial proteins, such as in the transcription factor E4F1.
results suggest that E4F1 may neutralize the capacity of HBx to activate a p53 (show TP53 Proteins)-dependent, metabolic and growth arrest phenotype in liver cells, thus possibly contributing to the viability and proliferation of HBV-infected cells
Short hairpin RNA-mediated depletion of E4F1 induced mitochondrial defects and ROS-mediated death in several myeloid leukemia cell lines.
association of p120E4F with p14ARF enhances cell cycle inhibition
Specific inactivation of RASSF1A (show RASSF1 Proteins) by short interfering RNA disrupts binding of RASSF1A (show RASSF1 Proteins) to p120 (show HNRNPU Proteins)(E4F) in tumor cells.
E4F1 function involves ER alpha (show ESR1 Proteins)-mediated inhibition of VSMC proliferation and estrogen-related atheroprotection of human
findings show that full-length E4F1 protein but not its E1A (show BCKDHA Proteins)-activated & truncated form interacts in vitro & in vivo with FHL2 (show FHL2 Proteins); this E4F1-FHL2 (show FHL2 Proteins) association occurs in the nuclear compartment & inhibits the capacity of E4F1 to block cell proliferation
E4F1 is a key posttranslational regulator of p53 (show TP53 Proteins), which modulates its effector functions involved in alternative cell fates: growth arrest or apoptosis.
LANP (show ANP32A Proteins) and ATAXN1 interact in E4F-mediated transcriptional repression.
Acute inactivation of E4F1 in these cells results in CHK1 (show CHEK1 Proteins)-dependent checkpoint deficiency and multiple mitochondrial dysfunctions that lead to increased ROS (show ROS1 Proteins) production, energy stress, and inhibition of de novo pyrimidine synthesis
Altogether, our results classify E4F1 as a master regulator of CHK1 (show CHEK1 Proteins) activity that ensures high fidelity of DNA replication, thus safeguarding genome stability.
deletion of E4F1 resulted in the death of histiocytic sarcoma cells and tumor regression in vivo and extended the lifespan
identify a regulatory axis essential for epidermal stem cell-dependent skin homeostasis implicating E4F1 and the Bmi1 (show BMI1 Proteins)-Arf-p53 (show TP53 Proteins) pathway.
Results establish a crucial role for E4F during early embryonic cell cycles and reveal an unexpected function for E4F in mitosis.
The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence.
transcription factor E4F1
, E4F transcription factor 1
, transcription factor E4F1-like
, putative E3 ubiquitin-protein ligase E4F1
, transcription factor E4F
, transcription factor phi AP3
, deoxyribonuclease 1-like 2